Is it possible to get pregnant with thrush (vaginal candidiasis)

Compound

Gel 1% contains the active substance clotrimazole at a concentration of 10 mg/g and auxiliary components: propylene glycol, macrogol 400, carbomer, rectified ethyl alcohol 96% from food raw materials, glycerol, sage ethereal extract.
The 1% cream contains the active ingredient clotrimazole at a concentration of 10 mg/g and auxiliary components: cetostearyl and benzyl alcohols, polysorbate 60, synthetic spermaceti, octyldodecanol, sorbitan stearate, water.

The 1% ointment contains the active ingredient clotrimazole at a concentration of 10 mg/g and auxiliary components: polyethylene oxides 400 and 1500, propylene glycol, methylparaben, nipagin.

The 1% solution contains the active ingredient clotrimazole at a concentration of 10 mg/ml (in terms of dry matter) and auxiliary components: polyethylene glycol 400, propylene glycol, ethanol 96%.

1 suppository (candle) contains 100 mg of the active ingredient clotrimazole and semi-synthetic glycerides in the volume required to obtain a suppository weighing 2 g.

The tablets contain 100, 200 or 500 mg of the active ingredient clotrimazole and auxiliary components: lactose in the form of monohydrate, potato starch, adipic acid, sodium bicarbonate, silicon dioxide in colloidal form, sodium lauryl sulfate.

Release form

• gel 1% (pack of 20 and 40 g);
• cream 1% (tubes 15, 20, 30 and 50 g);
• ointment 1% (tubes 15, 20, 30 and 40 g);
• 1% solution (15 ml bottles);
• vaginal suppositories 0.1 g (package No. 6);
• vaginal tablets 0.1, 0.2 or 0.5 g (packaging No. 1, No. 3, No. 6; tablets are equipped with an applicator).

Clotrimazole can also be produced in the form of granules, powder for external use, or spray.

The drug is intended for local (including intravaginal) and external use; tablets for oral administration are not available.

How to take Clotrimazole

Recommended dose:

Clotrimazole cream is injected as deep as possible into the vagina once a day (preferably before bedtime) for 3 days without a break. A sufficient course of treatment with the cream is 3 intravaginal applications, according to the procedure described below. Additionally, a cream may be needed to relieve the external itching and burning sometimes associated with a vaginal yeast infection. Clotrimazole is for vaginal use only and should never be taken orally. The treatment course should not be carried out during the menstrual cycle. Treatment should be completed before the onset of menstruation. Although it is possible that sexual relations may occur during treatment with Clotrimazole, it is preferable for couples to wait until the end of the treatment course to prevent infecting your partner.

Applicator filling:

Remove the cap from the Clotrimazole tube, press and pierce the aluminum foil with the tube cap. To refill the applicator, screw the open end of the applicator barrel onto the threaded neck of the tube. Carefully begin squeezing the cream out of the tube. After this, the upward movement of the piston draws the required amount of cream into the applicator cylinder. As the applicator fills, the piston moves outward. When the plunger reaches its stop and stops, the proper amount of Clotrimazole has already been filled into the applicator and the applicator can be unscrewed from the tip of the tube. Close the cap and reserve the tube for the next use.

Insertion of the cream: Clotrimazole cream is inserted into the vagina in the same way as a tampon, standing, crouching or lying on your back, in a position convenient for you. Insert the filled applicator into the vagina. The depth of insertion depends on how comfortable you feel during insertion. Hold the applicator cylinder steady and insert the cream into the vagina, gently pressing the applicator piston until it stops. Inject the cream as deep into the vagina as possible, which will ensure the maximum effect of the drug. Remove the applicator.

Use for each procedure .

External use of the cream:

A small amount of Clotrimazole cream may be applied to the external opening of the vagina to provide additional relief from external symptoms. Squeeze a small amount of cream onto your finger and gently spread over the irritated vaginal area. The cream should be used once or twice a day and only during the period when external symptoms are present, no more than 7 days.

If you use more Clotrimazole than recommended

If you have used more Clotrimazole than recommended, consult your doctor immediately, contact the emergency and emergency department at your nearest hospital, even if there are no symptoms.

Possible side effects

If you develop a rash or new irritation while using the drug, stop using the drug and contact your doctor.

This is not a complete list of side effects. If unexpected side effects occur while using Clotrimazole, consult your doctor or pharmacist.

Side Effect Reporting:

If you notice any side effects, tell your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Medicines and Medical Technologies named after. Academician E. Gabrielyan by going to the website www.pharm.am to the “Report a side effect of a drug” section and fill out the form “Card of reporting a side effect of a drug.” Scientific center hotline phone number: +37410237665; +37498773368

How to store Clotrimazole

Store at room temperature, dry and out of reach of children.

Shelf life – 3 years.

Package contents and additional information

What Clotrimazole contains

Each gram of Clotrimazole 2% vaginal cream contains:

active substance: clotrimazole – 20 mg;

other components: ceteareth-12, ceteareth-20, liquid paraffin, cetostearyl alcohol, methylparaben, propylparaben, propylene glycol, dimethicone, purified water.

What Clotrimazole looks like and contents of the pack

Homogeneous cream of smooth white color, odorless.

Description of packaging

50 g of vaginal cream in an aluminum tube along with 3 vaginal applicators and a leaflet in a cardboard pack. The capacity of one applicator is 6 g Clotrimazole 2% vaginal cream.

Vacation conditions

Dispensed by prescription.

Pharmacodynamics and pharmacokinetics

Clotrimazole is an imidazole .

In vitro, it exhibits high activity against the most pathogenic fungi that can cause serious infectious complications, namely:

• dermatophytes (Microsporum sp., Epidermophyton floccosum, Trichophyton sp.);
• yeast-like fungi (Cryptococcus neoformans, Candida sp.);
• dimorphic fungi (Histoplasma capsulatum, Paracoccidicides brasiliensis, Coccidiodes immitis).

The mechanism of action of clotrimazole is based on its ability to block the synthesis of proteins, nucleic acids and ergosterol, which is necessary for the construction of cell membranes of fungi. As a result, the cell membranes of the fungi are damaged and the cells die.

At low concentrations, clotrimazole has a fungistatic effect. If the dose exceeds 20 mcg/ml, the drug has a fungicidal effect, and not only on proliferating cells.

When used in high doses, it helps to increase the concentration of hydrogen peroxide in the fungal cell to a toxic value and, as a result, destroys the fungal cells.

When applied topically, the drug is absorbed by the epidermis. The highest concentration of the substance is determined in the reticuloderm. It is also able to penetrate the keratin of nails.

Clotrimazole enters the systemic circulation in very small quantities. Metabolized in the liver to inactive substances that are excreted from the body in feces and urine.

When administered intravaginally, 5 to 10% of clotrimazole is absorbed. The absorbed substance is metabolized in the liver. Metabolic products are excreted in bile.

Clotrimazole

Over the past few decades, the problem of fungal diseases has become particularly relevant. This is largely due to the progression of immune disorders, which leads to an increase in the incidence of mycoses and a more severe course of the pathological process. One of the drugs that helps solve this problem is Clotrimazole. According to its chemical structure, it belongs to imidazole derivatives and has a wide range of antifungal effects. The fungicidal properties of the drug are due to its ability to disrupt the formation of one of the key elements of the cell wall of the parasitic fungus - ergosterol, which provokes a change in the morphology and properties of the cell, and ultimately causes its death (lysis). The ability to be fungistatic (inhibit the growth and development of parasitic fungi) or fungicidal (destroy them) is determined by the concentration of Clotrimazole in vitro: in the first case, from 1 μg/ml to 10 μg/ml of the active substance is sufficient. At a higher dose, the drug has a fungicidal effect against most known types of fungi. For candidiasis, Clotrimazole exhibits a fungicidal effect starting at 2 μg/ml. Sensitivity to Clotrimazole has been noted in dermatophytes, molds, yeasts (including “red” yeast, candida), in the causative agents of pityriasis versicolor and erythrasma. In addition, the drug exhibits an antibacterial effect against the most common opportunistic gram-positive microorganisms (staphylococci, streptococci), certain genera of gram-negative bacteria (gardnerella, bacterioides), as well as Corynebacterium minussimum, Malazessia furfur and Trichomonas vaginalis.

Due to poor absorption through the skin and mucous membranes, the drug does not have a systemic effect and associated side effects.

Clotrimazole is available in several dosage forms: vaginal cream, suppositories and tablets, cream and ointment for external use. In domestic pharmacies, the drug with the trade name “Clotrimazole” in the form of branded generics and generics can be found from several manufacturers at once, including Russian (Atoll, Avexima, GlaxoSmithKline Trading, ZiO-Zdorovye, Sintez, Ozon, Akrikhin) and foreign pharmaceutical companies: Esparma (Germany), Hyperion (Romania), Farmaprim (Moldova), Sedate Helcare (India), Medana Pharma (Poland), Teva (Israel), Shreya (India). Considering the lack of absorption through the skin and, therefore, systemic (not only locally, but also on remote organs and tissues) action, the use of Clotrimazole in high doses is not associated with life-threatening reactions. Poisoning by the drug is possible only through inappropriate (in this case, oral) use. Symptoms of toxicosis caused by Clotrimazole are nausea, vomiting, epigastric pain, anorexia, liver dysfunction, dermatological reactions, polyuria. In such a situation, the use of activated carbon is indicated.

Indications for use: what is Clotrimazole ointment, cream, gel, suppositories and tablets for?

What do Clotrimazole ointment, gel, cream and solution help with?

The drug is prescribed for the treatment of fungal skin infections that are caused by molds and yeasts, dermatophytes and other pathogens sensitive to clotrimazole.

They are also used as remedies for lichen caused by Malassezia furfur and erythrasma (caused by Corynebacterium minutissimum).

Clotrimazole ointment, cream, gel and solution help: against nail fungus ( onychomycosis , fungal paronychia ), trichophytosis , dermatophytosis , fungal erosion and diaper rash, candidiasis , microsporia , epidermophytosis , dermatomycosis , complicated by secondary pyoderma mycoses.

Indications for the use of ointment, gel, cream and solution include infectious diseases, pathogens that are resistant to nystatin and a number of other antifungal agents.

for the treatment of pityriasis rosea , since this disease most likely has a viral or infectious-allergic origin, and may also be the body’s response to a severe shock or nervous breakdown. Clotrimazole is effective against fungal infections.

The use of Clotrimazole ointment, gel and cream with Clotrimazole in gynecology is indicated:

• for the treatment and prevention of thrush ;
• for the prevention of repeated fungal infections of the female reproductive system, which develop during long-term treatment with antibiotics or against the background of immunodeficiency conditions.

Also, solution, gel, cream and ointment in gynecology are used to sanitize the genital tract before delivery.

Candles - what are they for?

The indication for the use of vaginal suppositories is vaginal candidiasis and genital superinfections caused by microorganisms sensitive to clotrimazole. The drug is prescribed to women and, after the onset of sexual activity, to teenage girls.

What are Clotrimazole tablets for?

Clotrimazole tablets are used to treat blastomycotic infections of the vulva and vagina. In particular, the drug is prescribed for vaginitis caused by fungi of the genus Candida (including diseases caused by strains resistant to nystatin), caused by other pathogens sensitive to clotrimazole, superinfections of the genital organs, for sanitization of the genital tract before delivery.

Is it possible to get pregnant with thrush (vaginal candidiasis)

Vaginal candidiasis or thrush. What questions does a woman have with this diagnosis? What should be taken into account during the treatment of thrush, and what medications are available to treat and prevent this disease?

Vaginal candidiasis or thrush. What questions does a woman have with this diagnosis? What should be taken into account during the treatment of thrush, and what medications are available to treat and prevent this disease?

First, let's figure out what vaginal candidiasis is. It should be noted that vaginal candidiasis (thrush) is not a sexually transmitted disease and is considered together with them due to a similar clinical picture. The cause of this disease is a bacterium of the genus Candida. These microorganisms are present on the skin and mucous membranes (in the mouth and intestines) of most healthy people, but the disease is caused not simply by the presence of Candida fungi, but by their reproduction in large numbers.

In order to get vaginal candidiasis, it is not at all necessary to communicate closely with a man. This problem does not at all indicate promiscuity or non-compliance with the rules of intimate hygiene. Fungi can enter a woman's genital tract from the intestines and through contaminated objects. In addition, the disease appears when a person’s body’s defenses are reduced. For example, this happens with long-term use of antibiotics or poor nutrition. The disease also often develops against the background of impaired metabolism. Thrush affects people with chronic diseases - diabetes, tuberculosis, inflammation of the appendages, diseases of the digestive system, dysbacteriosis.

Factors contributing to the development of candidiasis (thrush):

taking antibiotics, douching, wearing tight underwear (especially synthetic). (Remember that underwear should not cause you discomfort, so give preference to natural fabrics).pregnancy. (Don’t worry, thrush “out of the blue” appears in many expectant mothers. It does not threaten the well-being of your baby, but the disease still requires treatment. However, in the first trimester of pregnancy, almost all fast-acting modern medications are not allowed to be used. You can use vaginal baths with solutions of antiseptics and herbs, as well as suppositories with nystatin. You should refrain from using other drugs for now. In the second and third trimesters of pregnancy, you can already use suppositories and cream "Pimafucin" and local products with clotrimazole - "Candide", which is produced in in the form of 1% cream and 1% solution. Good results are obtained by complex treatment, which involves the use of both vaginal tablets (for example, Candide-B6) and a cream that is applied externally to the groin area. Diabetes mellitus, HIV infection.

How does genital candidiasis (thrush) manifest?

Symptoms of candidiasis in men:

itching, soreness and redness of the glans penis, swelling of the glans penis and foreskin, white curdled coating on the glans penis, pain during intercourse

Symptoms of candidiasis in women:

itching, soreness and redness in the vaginal area and external genitalia; white, curd-like discharge from the vagina; pain during intercourse; pain during urination

Is genital candidiasis (thrush) dangerous?

Candidiasis of the genital organs does not cause any particular harm to health. However, it causes a lot of anxiety to the patient and interferes with normal sexual life. In addition, candidiasis (thrush) can be a sign of serious general diseases (for example, diabetes and HIV infection).

What treatment is indicated for genital candidiasis (thrush)?

There are many medications available to treat genital candidiasis (thrush). Some of them are used topically (ointment, vaginal tablets or suppositories), others are used orally (tablets or capsules for oral administration).

For mild cases of genital candidiasis (thrush), local treatment is usually sufficient. Drugs for topical treatment of this disease include (international names listed first, followed by commercial names in parentheses):

clotrimazole (Antifungol, Yenamazole 100, Candibene, Kanesten, Kanison, Clotrimazole) is the most common drug for local treatment of genital candidiasis (thrush) isoconazole (Gynotragen Ovulum) miconazole (Ginezol 7, Ginodaktarin, Klion-D 100) natamycin (Pimafucin) nystatin (Polygynax, Terzhinan).

It is worth noting that nystatin (both for topical use and for oral administration) is an outdated drug. In some cases, it is ineffective, since fungi of the genus Candida can be resistant to it.

For mild cases of candidiasis, it is enough to take just one such capsule orally at a dosage of 150 mg. But if candidiasis appears every month, for prevention you need to take one capsule monthly. Be careful with these medications if you have severe liver or kidney disease. For recurrent thrush, along with suppositories, it is necessary to use one of the general-action drugs, one tablet per day with meals. The course of treatment usually consists of five days.

Keep in mind that women over 50 years of age, people with liver disease, adrenal dysfunction, and allergic reactions to the medications Nizoral and Oronazole should be taken with extreme caution.

What is possible prevention of genital candidiasis (thrush)?

Prevention of genital candidiasis (thrush) comes down to the prescription of antifungal drugs for local or systemic use during treatment with antibiotics and when exposed to other factors that reduce general and local immunity.

Treatment of thrush in adolescence

Girls who are not sexually active should take sitz baths with a solution of furatsilin or weak infusions of medicinal herbs - sage, calendula, chamomile. If such remedies do not help, you can try Polygynax vaginal capsules, but only those that are adapted for girls and teenage girls. Be sure to check this when buying medicine at the pharmacy.

ON A NOTE

If you have genital candidiasis (thrush), then having sex will most likely be impossible due to pain. If the pain is minor, then you can have sex, but with a condom.

When taking a course of antifungal therapy, do not forget to treat your man at the same time. He will also need tablets (for example, MIKOmax once) and external medications in the form of creams, for example, mifungar cream. If only you are treated, then at any moment you risk getting candidiasis again from your husband.

Yaroslava PRUDNIKOVA Take the first step - make an appointment!

or call 8 800 550-05-33

free phone in Russia

Side effects

Allergic reactions.

When applied to the skin, the following side effects are possible:

• burning;
• edema;
• the appearance of blisters;
• erythema;
• skin irritation;
• tingling sensation
• peeling.

Local use for urogenital mycoses may be accompanied by burning, itching, swelling and hyperemia of the mucous membrane, intercurrent cystitis , the appearance of vaginal discharge, increased urination, pain during sexual intercourse.

When applied topically for mycoses of the oral cavity, redness of the mucous membrane, tingling and burning sensation at the site of application of the drug, and irritation may be observed.

Instructions for use of Clotrimazole (Method and dosage)

Clotrimazole ointment, instructions for use

Before applying Clotrimazole ointment (Acri or other manufacturers), the affected areas of the body are first washed with soapy water and dried thoroughly.

The drug is applied to the affected areas (covering small areas of healthy skin around the lesion) in a thin layer from 1 to 3 r./day. and rub lightly.

For 1 treatment of an area the size of a palm, a 5 mm strip of ointment is sufficient.

Regardless of what pathogen causes the disease, treatment after relief of subjective symptoms is recommended to continue for another 2 weeks.

For dermatomycosis, the course of treatment lasts from 3 to 4, for erythrasma - from 2 to 4, for lichen versicolor - from 1 to 3 weeks.

If there is no clinical improvement after 4 weeks of regular use of the drug, the patient is sent for a repeat microbiological study and the treatment regimen is revised.

The use of ointment for thrush in women helps block the spread of fungal cells and, when higher doses are prescribed, ensures their complete destruction. For therapeutic purposes, Clotrimazole for thrush is used 2 times a day, rubbing the ointment into the affected areas of the perineum.

Until the drug is absorbed, it is recommended not to wear underwear.

For men, the method of use for thrush and other fungal infections of the genital organs ( candidal balanoposthitis , urogenital candidiasis ) is the same as for women.

The ointment is applied to the foreskin and glans penis and gently rubbed into the skin and mucous membrane. Frequency of applications - 2 times/day.

The drug is poorly absorbed into the skin, and its active substance is characterized by the ability to gradually accumulate in the upper layer of the skin. Thanks to these properties, Clotrimazole ointment is highly effective for thrush in men and women.

Clotrimazole cream, instructions for use

The cream is intended for topical use. For thrush and other fungal diseases, apply it to the affected areas twice or thrice during the day and rub in lightly.

If mycoparasites affect the genitals, to treat thrush, the cream is prescribed simultaneously to both partners. For candidal balanitis or balanoposthitis, clotrimazole cream for men is used in the same way as ointment.

The duration of the course depends on the indications for use and ranges from 1-2 (for candidal balanitis/vulvitis ) to 3-4 weeks (for dermatomycosis ).

To prevent relapse of the disease, it is very important not to stop treatment for another 2 weeks after the subjective symptoms of infection disappear. If there is no improvement after 4 weeks of therapy, the patient should consult a doctor.

Vaginal cream Clotrimazole is administered into the vagina in portions of 5 grams 1 time per day. within 3 days.

Instructions for Clotrimazole solution

Before applying Clotrimazole, the skin should be washed with warm soapy water (especially the areas between the fingers) and dried well. The affected areas are treated 2-3 times a day. The amount of solution should be sufficient for uniform application to the entire affected surface.

If the skin of the feet is affected, liquid Clotrimazole solution must be applied after each wash.

The solution is the most preferred dosage form for onychomycosis . This is due to the fact that it has the best penetrating properties.

For fungal infections of the oral cavity, the affected areas of the mucous membrane are treated with a cotton swab or swab, onto which drops are first applied (10 to 20 drops are enough to treat each ear). Frequency of procedures - 3-4 rubles/day.

After applying Clotrimazole, you should refrain from eating and drinking for an hour.

Clotrimazole drops are also effective against onomycosis caused by yeast fungi. Drops are administered into the ear using turundas: a twisted cotton ball is moistened in the solution and 3-4 times a day. Place it in the ear canal for 5-10 minutes. Treatment lasts from 3 to 4 weeks.

Instructions for Clotrimazole gel

The method of using the gel is similar to the method of using the ointment. The product is applied to the epidermis affected by mycoparasites 2-3 times a day. and rub in with light movements.

The peculiarity of this dosage form is that the gel is well distributed on the skin and is also well absorbed into it. This allows the drug to be used for treating hard-to-reach areas of the body.

The gel is used intravaginally in the same way as clotrimazole cream: 1 r./day. 5 grams each. The course of treatment is 3 days.

Clotrimazole vaginal tablets, instructions for use

In the absence of other prescriptions, Clotrimazole Acri tablets and synonymous drugs for thrush and other fungal infections of the genital organs are used:

• for 3 days, 1 tablet 2 times a day;
• for 6 days, 1 tablet 1 time per day.

How to administer Clotrimazole vaginal tablets? Before administration, the tablet is removed from the package and moistened with chilled boiled water. The drug should be administered in the “lying on your back” position with your knees bent.

In order for the tablet to completely dissolve and clotrimazole to work, a moist environment is necessary (otherwise, undissolved particles may spill out). Therefore, the tablet is inserted into the vagina as deeply as possible. It is optimal to carry out the procedure before bedtime.

Treatment must be stopped before menstruation begins. Menstrual flow will wash away the drug and it will not have the desired effect. During treatment with vaginal tablets, you should not use tampons, spermicides, intravaginal douching or any other vaginal products.

To sanitize the genital tract before delivery, a woman is given a single dose of 200 mg of clotrimazole.

During pregnancy, the drug is contraindicated in the 1st trimester. At later stages, clotrimazole does not have an adverse effect on the development of the fetus, however, the use of the applicator may be associated with certain risks.

Instructions for Clotrimazole suppositories

Suppositories for thrush are used intravaginally. The drug should be injected deep into the vagina, one dose daily for 6 days. A repeat course is possible after consulting a doctor.

Clotrimazole suppositories for thrush and other urogenital mycoses are not used during menstrual bleeding. Treatment must be completed before it begins.

During pregnancy, the drug in this dosage form is used from the 2nd trimester and in situations where the expected benefit to the mother outweighs the possible risks to the fetus.

Reviews allow us to conclude that the drug quickly destroys fungal colonies and eliminates the unpleasant symptoms of mycoses. Its other advantages include low price and a large selection of dosage forms.

Application of ointment

Before applying Clotrimazole, clean the problem area with baby soap and water and dry thoroughly. The towel used must be disinfected. The drug is used to treat several pathological processes:

• Thrush

Candidiasis affects the mucous membranes of the body. When the genital form develops in women, the drug is applied using a special applicator; upon completion of the procedure, the patient must remain in a supine position for at least half an hour. Both external and internal genitalia are treated. Due to poor distribution of the ointment over the skin surface, Clotrimazole cream or vaginal suppositories are more often used. Therapy is carried out for up to 30 days.

For men, weekly manipulations with the medicine are enough to combat candidiasis. The medication is applied to the mucous membranes affected by the fungus and rubbed in gently. If one of the sexual partners is infected, the other automatically undergoes preventive therapy, even in the absence of obvious symptoms.

• Fungal infection of nails and feet

When applying the product, not only the lesion is captured, but also the nearby healthy skin. After careful rubbing, linen or cotton socks are put on the feet, and the inner surface of the shoes is treated for prevention.

Nail plates are treated with Clotrimazole solution; they are cut short before treatment. Therapeutic measures take place over 1-2 months, supplemented by one week of prophylaxis.

• Depriving

The drug is prescribed to combat the ringworm, pityriasis type of pathology. Surfaces affected by the fungus are treated evenly, and additional disinfectants are used: iodine solution, etc. In difficult cases, therapy is supplemented with fungicides for oral administration. Treatment is carried out three times a day for 3 weeks. After completion of the course, preventive treatment continues for another 5 days.

• Dermatitis

Clotrimazole is active against atopic, seborrheic, and diaper dermatitis. In the first case, the ointment is used:

• for the face – three times a day;
• for the scalp – 2 times a day.

For babies, the drug is applied once every 24 hours. Therapy takes up to one calendar month, prevention of relapses takes another 5-7 days. For atopic dermatitis, the medicine is included in complex treatment with other medications. The diaper form of the pathology allows treatment within 5 days. Additional medications may be used.

Overdose

When applied to the skin and intravaginally, there is no risk of acute intoxication, since clotrimazole enters the systemic circulation in very small quantities.

In case of accidental ingestion of Clotrimazole, nausea, anorexia , vomiting, gastralgia , and liver dysfunction . In rare cases, pollakiuria , hallucinations , drowsiness, and allergic skin reactions are observed.

In this case, the patient is prescribed enterosorbents and symptomatic treatment. Gastric lavage is performed in situations where a life-threatening dose was taken within the previous hour, as well as in the presence of visible symptoms of an overdose (nausea, dizziness, vomiting).

special instructions

Avoid ingestion and contact with eyes.

For mycoses, all affected areas of the body should be treated simultaneously.

The use of vaginal tablets, unless otherwise advised by a doctor, is contraindicated in the presence of any of the following symptoms:

• acyclic vaginal bleeding;
• bloody discharge or pathological bleeding from the vagina, uterine hemorrhages ;
• dysuria;
• lower abdominal pain;
• open sores, blisters, or ulcers of the vagina or vulva;
• any unpleasant symptoms that are associated with the use of Clotrimazole (irritation, redness, burning, swelling, etc.);
• chills or fever with a temperature above 38 ° C;
• nausea and/or vomiting;
• vaginal discharge with an unpleasant odor;
• diarrhea;
• pain in the shoulder or back.

To prevent reinfection, treatment is prescribed to both partners simultaneously. The optimal dosage form for men is cream.

For trichomoniasis, in addition to the drug, chemotherapeutic agents are prescribed for systemic treatment ( Metronidazole ).

Which is better, Clotrimazole ointment or cream?

The choice in favor of one or another dosage form is made depending on the indications. Clotrimazole ointment for women and men is prescribed for diseases that are accompanied by increased dryness and flaking of the skin.

As a rule, these are skin mycoses caused by dermatophytes ( trichopytosis , microsporia ), athlete's foot inguinal , erythrasma , pityriasis versicolor , isolated cases of smooth skin candidiasis , mixed bacterial and fungal infections.

For weeping inflammatory processes, it is more advisable to use a cream that has a drying effect.

Thrush: a common problem with improper treatment

Every woman knows what candidiasis (“thrush”) is. And each has a “proven” remedy. But what if symptoms return? Why can candidiasis persist? And how to find an individually effective medicine?

Why does Candida fungus “grow”?

1. Lactobacillus deficiency

As is known, the basis of female microflora is lactobacilli. The share of which, ideally, is at least 85%.

The remaining 15% are dozens of species of opportunistic bacteria and 4 species of Candida fungi. The presence of which is acceptable and safe, but only in limited quantities.

Control of the number of such pathogens is carried out by lactobacilli, which secrete lactic acid and hydrogen peroxide. And while there are enough of the latter, “conditionally harmful” ones are not capable of reproduction.

To maintain normal activity, lactobacilli need food - glycogen from the surface cells of the vaginal epithelium ("dead from old age").

And the rate of epithelium renewal, that is, “replenishment of food reserves,” in turn, depends on the balance of estrogen.

Thus, a decrease in lactobacilli and the “overgrowth” of fungi and other pathogens against this background is often associated with an imbalance of estrogen and is observed with:

• Diseases or decreased ovarian function,
• When taking certain oral contraceptives;
• Against the backdrop of acute stress
• Against the background of sudden weight loss (fat is needed for the synthesis of estrogens).

Mechanically, frequent douching and other similar procedures that “wash away” the surface layer of cells and a certain amount of beneficial flora can provoke disturbances.

Well, among other reasons:

• inflammatory diseases
• sexually transmitted infections
• long-term and/or “non-targeted” use of antibiotics
• and the use of antibacterial/antiseptic suppositories.

2. Insufficiency of immunity

“Thrush” may also be associated with immune disorders, since Candida is “under the supervision” of local defenses.

And another risk factor for candidiasis are:

• various immunodeficiency conditions
• chronic pathologies that adversely affect the immune system (diabetes mellitus, thyroid pathologies, oncological processes, etc.),
• taking glucorticoid hormones.

3. Household reasons

Well, the most “banal” provocateur of the violation may be the regular use of sanitary pads, wearing synthetic underwear and some other factors that create conditions for increased local temperature, oxygen deficiency and high humidity. That is, what fungi of the genus Candida “love”.

Candidiasis or “other”

If you suspect a risk of candidiasis, you can already based on the presence of the listed factors. It is not easy to distinguish candidiasis from vaginosis at first glance.

At the same time, the treatment of one and another pathology is fundamentally different. And the use of non-targeted therapy leads to chronicity of the process and the development of complications, including infertility.

The nature of the discharge can help determine candidiasis by eye - white, cheesy, with a sour odor, accompanied by severe itching. However, not everyone has such “classic” signs and not always.

Vaginosis (bacterial vaginosis) often “has” copious white-gray, sometimes foamy, discharge, with an alkaline (“fishy”) odor, which intensifies after sexual intercourse. Sometimes with itching. However, even here the nature of the symptoms varies greatly. And, among other things, violations can be combined.

Thus, to accurately distinguish candidiasis from other forms of vaginal dysbiosis, a flora analysis will be required.

And the most complete picture can be obtained from the “Florocenosis” analysis.

The study includes calculations:

• lactobacilli,
• causative agents of bacterial vaginosis Gardnerella vaginalis
• and Atopobium vaginae,

which makes it possible to differentiate several types of dysbiosis at once and apply the correct treatment.

Typing fungi of the genus Candida allows you to select an effective antifungal drug. After all, not everyone knows, but some of the listed types have pronounced resistance to popular means. You can get the typing result in the “Florocenosis” test or submit a vaginal smear for a separate fungal typing test in order to accurately determine the type of thrush pathogen and select the right antifungal drug.

Prevention of candidiasis

Summarizing all of the above and adhering to national clinical recommendations, we can conclude that the prevention of “thrush” in both women and men comes down to:

• maintaining personal hygiene,
• the use of barrier methods of contraception,
• abstaining from unprotected sexual intercourse with frequent changes of partners,
• avoiding uncontrolled use of hormonal and antibacterial drugs,
• exclusion from the “wardrobe” of tight, synthetic underwear,
• monitoring the state of general, hormonal and reproductive health.

In addition, women should:

• limit the use of sanitary pads to menstruation days only,
• exclude douching, vaginal douche and other similar procedures,
• prevent long-term use of intrauterine devices and vaginal diaphragms.

And pregnant women require special attention, due to physiological weakening of the immune system, changes in hormonal levels and stagnation of lymph in the pelvis due to increased intra-abdominal pressure. Which creates “favorable” conditions for the development of vaginal dysbiosis.

Clotrimazole analogs

Level 4 ATC code matches:
Daktarin

Oronazole

Isoconazole

Kandibene

Miconazole

Candide B

Nizoral

Kanesten

Mifungar

Ecodax

Econazole

Travogen

Bifonazole

Sebozol

Mycozolon

Mycozoral

Travocort

Mycospor

Mycospor Set

Dermazol

Synonyms of dosage forms for external use:

• Amyclone
• Imidil
• Kandibene
• Kandizol
• Candide
• Kanesten
• Kanizon
• Funginal
• Funugitsip

Analogues in the form of vaginal tablets:

• Candide
• Imidil
• Kandizol
• Kandibene
• Funginal
• Candid-B6
• Kanizon
• fungicip

Which is better: Candide or Clotrimazole?

Candida is synonymous with Clotrimazole. The basis of both drugs is the same substance, so there are no fundamental differences between them.

Clotrimazole or Pimafucin - which is better?

The main component of Pimafucin is the antimycotic antibiotic nitamicin . Sensitivity to the drug is predominantly caused by molds and yeasts (including the genera Penicillium, Candida, Cephalosporium, Aspergillus and Fusarium).

Pseudoallescheria boydii and dermatophytes are less sensitive to Pimafucin. That is, in situations where the cause of the disease is fungi of the genus Epidermophyton, Trichophyton or Microsporum, the choice should be made in favor of the drug Clotrimazole.

The use of Clotrimazole is less often accompanied by hypersensitivity reactions. In addition, it is less likely than Pimafucin to provoke imbalances in the microflora of the genital organs.

Pharmacological properties of the drug Clotrimazole

Clotrimazole belongs to the group of imidazole antifungal drugs. The antimycotic effect is due to a disruption in the composition of the fungal cell membrane, a change in its permeability and subsequent cell lysis. Has a wide spectrum of action. Effective against dermatophytes and yeast fungi. In addition, it has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria ( Bacteroides spp. , Gardnerella vaginalis ), as well as against Trichomonas vaginalis , Malassezia furfur , Corynebacterium minutissimum. Dosage forms of clotrimazole do not have a resorptive effect. When administered intravaginally, approximately 5–10% of clotrimazole is absorbed. The fungicidal concentration in the vagina remains for 3 days after application. The absorbed substance is metabolized in the liver and excreted in the bile.

Clotrimazole during pregnancy and lactation

Cream, gel, ointment, solution, suppositories and vag. tablets during pregnancy can be used from the 2nd trimester.

Strictly controlled studies regarding the safety of use during pregnancy; therefore, Clotrimazole is not prescribed in the 1st trimester.

Clinical studies regarding the effect of the drug on fertility in women have not been conducted; no adverse effects were detected in animal experiments.

Clotrimazole tablets and suppositories during pregnancy (in the 2nd and 3rd trimesters) do not have a negative effect on the fetus, but using the applicator can be dangerous.

When breastfeeding, the drug is used with caution, since it is unknown whether it passes into milk.

Gel, solution, cream and ointment Clotrimazole during pregnancy is applied to the skin affected by mycoparasites 2-3 times a day. If vaginal tablets are prescribed, they should be administered without an applicator. The duration of the course depends on the localization of pathological changes, the severity of the disease and the effectiveness of treatment.

Reviews indicate that in most cases the drug is well tolerated, and adverse reactions due to its use occur very rarely.

Use of the drug Clotrimazole

Prescribed in the form of ointment (cream), spray, solution for external use; vaginal tablets and vaginal gel. Cream, solution, spray is applied to the affected areas 2-3 times a day and rubbed in; course of treatment - up to 4 weeks or more. For mycoses of the feet (to avoid relapses), treatment is continued for 3 weeks after the symptoms of the disease disappear. Before applying clotrimazole, wash the feet with warm soapy water and dry (especially the interdigital spaces). To treat urogenital candidiasis, a 100 mg tablet is injected into the vagina at night for 7 days, and the vulva and perineal skin are lubricated with 1% clotrimazole cream; or 1 tablet 200 mg for 3 days; or a single 500 mg tablet. Vaginal gel: when treating genital infections, about 5 g of gel (1 full applicator) is injected as deep as possible into the vagina in the evening (before bed) for 6 days. Treatment should not be carried out during menstruation and should therefore be completed before it begins.

Reviews of Clotrimazole

Solution, ointment, cream, gel, suppositories and vaginal tablets Clotrimazole - reviews are eloquent confirmation of this - this is a time-tested, inexpensive and very effective remedy for nail and skin , as well as for urogenital mycoses .

In addition, the drug is effective against age spots .

Reviews of Clotrimazole suppositories on forums are mostly as follows:

• “... It’s the only thing I use to treat thrush. The product is cheap, but it helps a lot. No side effects."

Important features of Clotrimazole, which are taken into account when prescribing it, are the possibility of:

• the use of suppositories, tablets, ointments, solutions, gels and creams for thrush during pregnancy;
• prescribing creams and ointments for the preventive treatment of a woman’s sexual partner.

No less good reviews from men about Clotrimazole ointment and reviews about the cream. The only drawback of the drug, men sometimes note, is that it should be used for a long time.

Clotrimazole price

The price of Clotrimazole in vaginal tablets in Russia is from 50 rubles per package of 100 mg 6 pcs. In Ukraine, the price of vaginal tablets starts from 30 hryvnia.

The price of Clotrimazole ointment 20 g in Russia is from 100 rubles; in Ukraine you can buy ointment for a price of 30 hryvnia.

The average price of a solution for external use in Russia is from 300 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Clotrimazole-Akrikhin solution for external use.
  approx. 1% fl. 15mlMedana Pharma A.O. RUB 331 order
• Clotrimazole cream 1% 20gGlaxoSmithKline Pharmaceuticals SA

  RUB 262 order

• Clotrimazole cream 1% 20gHyperion SA

  115 rub. order

• Clotrimazole lotion for nails. and skin micospray fl. 15 mlCorvette Pharma LLC

  130 rub. order

• Clotrimazole cream d/nar.prim. 1% tube 20g No. 1Ozon LLC

  RUB 139 order

Pharmacy Dialogue

• Clotrimazole-Akrikhin (vial 1% 15ml) Akrikhin OJSC

  330 rub. order

• Clotrimazole (vial 1% 15ml)Medana

  RUB 327 order

• Clotrimazole-Akrikhin ointment (tube 1% 20g) Akrikhin OJSC

  RUB 137 order

• Clotrimazole ointment (tube 1% 15g) Muromsky PZ

  63 RUR order

• Clotrimazole ointment (tube 1% 20g) Sintez (Kurgan) OJSC

  126 rub. order

show more

Pharmacy24

• Clotrimazole 25 g ointment PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine
  15 UAH. order
• Clotrimazole 100 g No. 6 vaginal tablets Evertogen Life Sciences Limited, India/Optimus Generics Limited, India

  31 UAH order

• Clotrimazole Fitofarm 15 g ointment PRAT "Fitofarm", Ukraine

  9 UAH order

• Clotrimazole 1% 20 g ointment Encube Ethicals Private Limited, India

  34 UAH order

• Clotrimazole Teva 200 mg No. 3 vaginal tablets Merkle GmbH, Nimechchina

  60 UAH.order

PaniPharmacy

• CLOTRIMAZOLE ointment Clotrimazole ointment 1% tube 20g India, Encube Ethicals

  43 UAH order

• CLOTRIMAZOLE ointment Clotrimazole ointment 15g Ukraine, Fitofarm ChAO

  12 UAH order

• CLOTRIMAZOLE tablets Clotrimazole tablets. vag. 100 mg No. 6 India, Optimus Generics Ltd

  31 UAH order

• CLOTRIMAZOLE tablets Clotrimazole tablets. vag. 100 mg No. 6 Poland, GlaxoSmithKline Pharmaceuticals

  41 UAH order

• CLOTRIMAZOLE liquid Clotrimazole solution 1% 25ml Ukraine, Borshchagovsky Chemical Plant PJSC

  20 UAH order

show more