SOLKODERM solution for external use, ampoule 0.2ml No. 1

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Radio wave removal of condylomas is an advanced method of removing these formations from the skin and mucous membranes. The procedure involves applying a radiosurgical instrument to the affected surface and has proven to be effective and relatively safe. The specialists of the Family Doctor clinic were among the first in the region to successfully use radio wave surgery, so our extensive practice allows us to achieve high efficiency of such manipulations.

Causes of condylomas and indications for removal

The reason for the formation of genital warts lies in infection with human papillomavirus. Formations that are located in areas of the skin subject to constant trauma must be removed first - constant mechanical stress can lead to infection (inflammation) and even malignancy. However, removal of condylomas with Solcoderm or radio waves is also preferred if they have formed on a “safe” area of ​​the skin, which is dictated by aesthetic considerations.

Solcoderm: instructions for use

Solcoderm can be used at home without any problems. To successfully remove a wart, papilloma, condyloma or other neoplasm, you must follow the generally accepted step-by-step method of applying the drug. Speaking about how to use and how to apply Solcoderm correctly, we can distinguish the following stages of treatment:

1. If the wart is of significant size and there is a corresponding ridge, then it must be quietly cut off using nail scissors.
2. The skin must be pre-treated with an antiseptic (you can use regular pure alcohol or an alcohol solution of salicylic acid).
3. Next, take a standard nourishing cream, which must be thoroughly coated with all the skin located around the tumor.
4. Then we open the ampoule with the medicine and pick up the applicator (always included). The applicator has a thick and sharp end.
5. If the neoplasm is large, then you need to use a blunt end; if the papilloma is small, then we will use a sharp end.
6. Then you need to dip the applicator with the selected end into the solution, applying a drop of the drug directly to the tumor, without touching healthy skin.
7. If there is a large tumor, one drop may not be enough for treatment, so in this case you need to take another drop, carefully distributing everything over the entire area of ​​the wart.
8. If there are multiple neoplasms on the skin in the form of papillomas or warts that have long grown together, then their cauterization and removal can be carried out using a glass capillary. To do this, lower the capillary into the solution, bring it to the skin and gradually treat the entire affected area.
9. It is not recommended to immediately apply large amounts of Solcoderm. Everything needs to be done so that the solution has time to absorb and dry - the main thing is that it does not spread and get on healthy skin, otherwise it can lead to a burn, which will have to be treated separately.
10. After treatment, the affected skin will gradually lighten and then acquire a pale grayish-yellow tint. If this is the color you observe, then no further processing is required - you just have to wait.

Important! If there are a large number of warts on one area of ​​skin at a time, it is recommended to treat no more than 3-4 new growths. If this does not produce results, cauterization can be repeated using Solcoderm only after 10-15 days.

After treatment, the area where Solcoderm was applied should be covered with a dark crust (the same as with normal damage to the skin). After a few days, the crust will begin to gradually come off, and after 1-2 weeks it will completely fall off.

Under no circumstances should Solcoderm be mixed with water, or other substances or medications, which is what some people usually do to obtain the mythical maximum treatment result. Nothing good will come of this.

Radio wave removal procedure

Radio wave removal of condylomas begins with preparatory measures. These include the following:

• Consultation and examination by a gynecologist;
• Determination of HPV type and concomitant infectious diseases;
• Blood test for HIV, syphilis, hepatitis;
• If necessary, colposcopy (examination of the affected area with a colposcope) and biopsy (histological examination of removed tissues is carried out after the procedure in order to clarify the diagnosis and exclude a malignant disease).

The removal operation itself is performed under local anesthesia: injections of anesthetics, a gel or a spray with an anesthetic effect can be used for these purposes. After performing anesthesia, the doctor proceeds directly to the removal - this is carried out with a radio knife, without contact with the patient’s skin. The method is based on the fact that high-frequency radio waves generate a large amount of thermal energy. The cellular fluid heats up, the structure is destroyed - the cells that are exposed immediately evaporate. Heat allows not only to “evaporate” the cells, but also to “seal” small vessels, which reduces the risk of bleeding and infection to zero and ensures rapid healing.

Skin lesions must be completely removed to prevent their reappearance. The area where the manipulation took place is treated with an antiseptic solution, and if necessary, an ointment application is carried out.

Solcoderm in the treatment of pathology caused by the human papillomavirus

The problem of diagnosing and treating diseases caused by the human papillomavirus (HPV) has attracted increasing attention in recent years due to the sharp increase in incidence, the significant contagiousness of the virus and its proven high oncogenicity. During mass studies in Europe, the human papillomavirus was found in 40 - 50 % of cases among those examined aged 15 to 49 years. However, from 5 to 20% of cases, patients require therapy.

HPVs are small DNA viruses, the characteristic feature of which is the ability to cause proliferation of the epithelium of the skin and/or mucous membranes. They belong to the papovavirus (Papova) family. The term Papova Viridae is formed from the first syllables of the names of viruses: pa (pa-) - papilloma virus (papilloma), po (- ro) - polyoma virus (polyema), va (- va) - monkey vacuolating virus. Currently, about 180 types of this virus (Human papillomavirus) are known, which differ in the degree of oncogenicity and preferences for topical presentation.

Papillomaviruses are the only group of viruses that induce the formation of tumors in humans under natural conditions (regardless of the immunosuppressive conditions of the body). In this regard, special control should be placed on processes caused by types of viruses belonging to a “high degree” of oncogenic risk: 16, 18, 39, 45, 46, 56, 59, 68, 73, 82, as well as their presence in combination with viruses 6 and 11 types. These oncogenic viruses often create keratinocytes with an unlimited life span. Special predisposition factors to malignant pathology of epithelial cells include, first of all, gene polymorphism of the human papillomavirus, as well as mutations of some genes in the body of patients. Mutations of HPV genes (gene variants E2, E6 - E7) in patients often determine an increased risk of precancerous pathology, which becomes possible as a result of modulation of replication and integration of the virus into the human genome. Moreover, it is the oncoproteins that determine the processes of malignancy in HPV-infected epithelial cells (interaction with the tumor suppressor protein Rb105, cyclin proteins and DNA repair enzymes). They induce systemic immunosuppression, reducing the immune response (suppressing the expression of major histocompatibility complex genes, inhibiting the maturation of antigen-presenting cells), and also cause local immunosuppression, inhibiting the antiproliferative and antiviral activity of interferons. The duration of infection of the human body with HPV creates conditions for the realization of its oncogenic potential.

The most common clinical manifestations of HPV infection are presented in the table. As a rule, each of the clinical forms is associated with a specific type of HPV.

There are clinical forms (visible to the naked eye or invisible, but in the presence of appropriate symptoms): warts (plantar, vulgar, flat, filiform (acrochorids), verrucous epidermodysplasia, papillomas of the larynx and/or oral mucosa, genital warts, giant condyloma of Buschke-Levenshtein ). In addition, subclinical forms are determined (not visible to the naked eye and asymptomatic, detected only by colposcopy and/or cytological or histological examination), as well as latent forms (the absence of morphological or histological changes when HPV DNA is detected).

Among the options for diagnosing HPV, you should indicate:

- clinical - visual - routine examination + adding a test with 3 -5% acetic acid and Lugol's solution ;

— cytological method (examination of smears according to Papanicolaou or staining of smears according to Romanovsky-Giemsa. It has low sensitivity (50-80%);

— histological examination of biopsy specimens;

- colposcopy (a study that allows you to assess the size and location of the lesion and exclude invasive cancer);

— determination of antibodies to HPV. To more accurately predict the clinical outcome of pathological changes in the cervix and identify the disease at an early stage, additional examinations are required, such as DNA diagnostics;

— molecular genetic methods (DNA diagnostics: determination of the human papillomavirus genome and typing of oncogenic and non-oncogenic pathogens — quantitative and screening PCR diagnostics). Real - Time PCR, Consensus PCR, NS - II.

Knowledge of the presence of tiny amounts of HPV DNA, obtained by high-quality PCR, is not sufficient for clinical practice today, because most patients may be HPV positive. In 70% of cases, virus carriage resolves spontaneously and it is not always possible to make a prognosis regarding the course of human papillomavirus infection based on PCR. A method that allows you to determine the viral load of HPV (in particular, the Digene test) has undoubted advantages, since all the main (13) highly oncogenic types of HPV are detected, and it is also possible to determine the clinically significant concentration of DNA in the tissue, which can serve as a prognostic criterion for the development of the disease and formulate the doctor’s tactics in each specific situation. Invasive cancer is registered on average at the age of 49 years, when additional immuno-hormonal changes occur that promote active invasion and metastasis.

Today, the following classification of therapy methods is optimal: destructive (physical: surgical excision, electrosurgical methods, cryotherapy, laser therapy); chemical (feresol; hydrogen peroxide; solutions of quinine and hingamine; preparations based on salicylic and lactic acids, trichloroacetic, nitric and acetic acids; thuja and celandine juices; Solcoderm ); cytotoxic drugs (podophyllin, podophyllotoxin, 5-fluorouracil); immunological and combined options.

Among the chemicals used in our country and abroad that have a destructive effect, about which sufficient positive information is presented in the literature, one can highlight trichloroacetic and nitric acids, as well as a combined acid preparation - solcoderm.

Solcoderm is an aqueous solution (0.2 ml in an ampoule, 1 piece per package), the active component of which is the reaction products of organic acids (acetic, oxalic and lactic) and metal ions (copper nitrate trihydrate) with nitric acid. Its mechanism of action is based on the oxidation reaction of nitric acid and its intermediate products.

The properties and mechanism of action of Solcoderm distinguish it from other destructive methods. When applied topically, Solcoderm causes immediate intravital fixation of the tissue to which it is applied. The effect of the drug is strictly limited to the place of application. A sign of an immediate effect is a change in the color of the treated area. The devitalized tissue dries out, darkens (mummifies) and a dense black-brown scab forms, which is rejected on its own over the next few days. The destruction caused by Solcoderm is based on intravital fixation with preservation of the basic structure of the neoplasm. In this case, there is no hydrolysis of the peptide bonds of proteins, leading to the dissolution of tissues. Considering that nitrous oxide (NO) plays an important role in protecting the body from bacteria, fungi and protozoa, which often accompany and support viral pathology, conditions are created to reduce the number of relapses of the disease, which determines the effectiveness of this drug. It is very important that with this mechanism of action only minor damage to the surrounding tissue is observed and no systemic resorptive effect is noted.

The healing process is short and complications (secondary infection or scarring) are rare. The therapy is practically painless and is carried out on an outpatient basis, as it does not require special equipment, but is applied with a glass capillary included in the package. After applying a small amount of the drug with a capillary tube, light pressure with a special plastic applicator facilitates its penetration into the tissue. The duration of the procedure is 15 minutes. Therapy for small lesions usually requires one treatment session. When treating large lesions - from 2 to 4 sessions.

The effectiveness of Solcoderm in the treatment of patients with various benign neoplastic formations of the skin and mucous membranes in the form of common or plantar warts is 85 - 94%, genital warts 80 - 87%, seborrheic keratosis 75 - 100% and actinokeratosis 80 - 100%, non-cellular nevus (with confirmed good quality) 98 - 100%. Demonstration of such high efficiency in the presence of safety, availability and ease of implementation of the therapy method allows us to recommend this drug for use in clinical practice.

S.V. Batyrshina

GOU DPO KSMA Roszdrav, Kazan

Advantages of the method

Removing condylomas using the radio wave method has many advantages:

• Low-traumatic - ease of tissue dissection without the usual scalpel, no impact on the upper layers of the skin, no mechanical damage to capillaries and tissues;
• The ability to control the depth of exposure of the radioknife, as well as the area of ​​impact on tissue - allows you not to affect surrounding healthy tissue;
• No rough scars after the procedure, which is especially important for patients planning pregnancy;
• Timely coagulation of blood vessels, which reduces the risk of bleeding and swelling;
• Speed ​​(no more than 30 minutes) and high efficiency of the procedure, quick rehabilitation period;
• Antiseptic effect of radio waves - reduced risk of infection, inflammation;
• Painless due to the lack of impact on sensitive receptors;
• Complete removal of affected tissue; minimal possibility of their reoccurrence
• Possibility of removing condyloma of any location;
• Preservation of high quality material for further laboratory research.

However, despite the advantages, radio waves may be contraindicated in some cases.

Recovery after deletion

After the doctor removes the condylomas, he will definitely explain the features of the recovery period. In the vast majority of cases, no complications are observed if you follow the specialist’s recommendations for 4-6 weeks:

• Avoid visiting baths, saunas, swimming pools, beaches, solariums;
• Prefer a warm shower to a hot bath;
• Limit physical activity, eliminate heavy lifting;
• Maintain sexual rest
• Use pads and avoid tampons;
• Don't drink alcohol.

Release form, packaging and composition of the drug Solcoderm

Solution for external use

transparent, colorless.

Excipients

: distilled water.

0.2 ml - colorless glass ampoules (1) complete with a plastic applicator (1) and glass capillaries (2) - contour cell packaging (1) - cardboard packs. 0.2 ml - colorless glass ampoules (5) complete with a plastic applicator (5) and glass capillaries (10) - contour cell packaging (1) - cardboard packs.