UNIDOX SOLUTAB tab 100mg N10

Nosological classification (ICD-10)

A49.3 Mycoplasma infection, unspecified
A53.9 Syphilis, unspecified
A54 Gonococcal infection
A55 Chlamydial lymphogranuloma (venereal)
A69.2 Lyme disease
A70 Chlamydia psittaci infection
A75 Typhus
H60 Otitis externa
H66 Suppurative and unspecified otitis media
H70 Mastoiditis and related conditions
J01 Acute sinusitis
J02.9 Acute pharyngitis, unspecified
J03.9 Acute tonsillitis, unspecified (angina agranulocytic)
J04 Acute laryngitis and tracheitis
J06 Acute upper respiratory tract infections of multiple and unspecified localization
J22 Acute respiratory infection of the lower respiratory tract, unspecified
J31 Chronic rhinitis, nasopharyngitis and pharyngitis
J32 Chronic sinusitis
J35.0 Chronic tonsillitis
J37 Chronic laryngitis and laryngotracheitis
K62.8.1* Proctitis
L08.9 Local infection of skin and subcutaneous tissue, unspecified
L70 Acne
M60.0 Infectious myositis
M65 Synovitis and tenosynovitis
M65.0 Tendon sheath abscess
M71.0 Abscess of bursa
M71.1 Other infectious bursitis
M86 Osteomyelitis
N30 Cystitis
N34 Urethritis and urethral syndrome
N39.0 Urinary tract infection without established location
N41 Inflammatory diseases of the prostate gland
N49 Inflammatory diseases of the male genital organs, not elsewhere classified
N71 Inflammatory diseases of the uterus, except the cervix
N73.9 Inflammatory diseases of the female pelvic organs, unspecified
N74.2 Inflammatory diseases of the female pelvic organs caused by syphilis (A51.4+, A52.7+)
N74.3 Gonococcal inflammatory diseases of the female pelvic organs (A54.2+)

Unidox Solutab price, where to buy

The average price of tablets in Russia is about 300 rubles. per pack 10 pcs.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Unidox Solutab dispersible tablets 100 mg 10 pcs. ZiO-Zdorovye ZAO
326 rub. order
Unidox solutab dispersant tablets. 100 mg 20 pcs. ZiO-Zdorovye ZAO
RUB 636 order

Pharmacy Dialogue

Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.
RUB 331 order
Unidox Solutab (table dispersant 100 mg No. 20)Astellas Pharma/ZiO-Zdorovye CJSC
625 rub. order
Unidox Solutab (table dispersant 100 mg No. 10) ZiO-Zdorovye CJSC/Astellas Pharma Europe B.V.
Read also: Why do acne appear in the bikini area? How to get rid of the problem?
RUB 305 order

Pharmacy24

Unidox Solutab 100 mg N10 tablets Astellas Pharma Europe B.V., Netherlands
141 UAH.order

PaniPharmacy

Unidox solutab tablets Unidox salutab tablets. 100 mg No. 10 Netherlands, Astellas Pharma Europe
152 UAH order

Pharmacodynamics

Broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).

As a rule, it has no effect on Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

The possibility of acquired resistance to doxycycline in a number of pathogens, which is often cross-linked within a group, should be taken into account (i.e., strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Description of the remedy

Unidox Solutab is nothing more than a broad-spectrum antibacterial drug .

Dermatologists, as well as cosmetologists, often prescribe it for the treatment of acne, usually with severe or moderate severity of skin rashes.

For isolated rashes, this remedy will either be ineffective or will not give any positive result at all.

How to determine what severity of acne you have? To do this, you will need minimal mathematical skills - just count the number of pimples on the skin.

If the skin is affected by a small number of blackheads (up to about a dozen pimples), this indicates mild acne. If you have more than ten acne on your face, including deep, painful formations, this indicates the middle stage of the disease.

The severe stage of acne is characterized by the presence of more than forty inflammatory formations on the skin.

Pharmacokinetics

Suction

Absorption is fast and high (about 100%). Food intake has little effect on the absorption of the drug.

Cmax of doxycycline in blood plasma (2.6–3 μg/ml) is achieved 2 hours after taking 200 mg; after 24 hours, the concentration of the active substance in blood plasma decreases to 1.5 μg/ml.

After taking 200 mg on the first day of treatment and 100 mg/day on subsequent days, the plasma concentration of doxycycline is 1.5–3 mcg/ml.

Distribution

Doxycycline binds reversibly to plasma proteins (80–90%), penetrates well into organs and tissues, poorly into the cerebrospinal fluid (10–20% of plasma levels), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation spinal membrane.

Volume of distribution - 1.58 l/kg. 30–45 minutes after oral administration, doxycycline is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissue, pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluids.

With normal liver function, the level of the drug in bile is 5–10 times higher than in plasma.

In saliva, 5–27% of the concentration of doxycycline in blood plasma is determined.

Doxycycline crosses the placental barrier and is secreted into breast milk in small quantities.

Accumulates in dentin and bone tissue.

Metabolism

A small portion of doxycycline is metabolized.

Removal

T1/2 after a single oral dose is 16-18 hours, after repeated doses - 22-23 hours.

Approximately 40% of the drug taken is excreted by the kidneys and 20–40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations

The half-life of the drug in patients with impaired renal function does not change, because its excretion through the intestines increases.

Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.

Unidox Solutab 100 mg 10 pcs. dispersible tablets

pharmachologic effect

Antibiotic, tetracycline.

Composition and release form Unidox Solutab 100 mg 10 pcs. dispersible tablets

Tablets - 1 tablet:

Active substance: doxycycline monohydrate 100.0 mg in terms of doxycycline;
Excipients: microcrystalline cellulose - 45.0 mg, saccharin - 10.0 mg, hyprolose (low-substituted) - 18.75 mg, hypromellose - 3.75 mg, colloidal silicon dioxide (anhydrous) -0.625 mg, magnesium stearate - 2, 0 mg, lactose monohydrate - up to 250.0 mg.

Dispersible tablets 100 mg.

10 tablets in a PVC/aluminum foil blister. 1 blister along with instructions for use in a cardboard box.

Description of the dosage form

Round, biconvex tablets, light yellow or grey-yellow to speckled brown, engraved “173” (tablet code) on one side and scored on the other.

Characteristic

Broad-spectrum antibiotic from the tetracycline group.

Directions for use and doses

Usually the duration of treatment is 5-10 days. The tablets are dissolved in a small amount of water (about 20 ml) to obtain a suspension; they can also be swallowed whole, divided into pieces or chewed with water. Preferably taken with food.

Take the tablets while sitting or standing, which reduces the likelihood of developing esophagitis and esophageal ulcers. The drug should not be taken immediately before bedtime.

Adults and children over 8 years of age weighing more than 50 kg are prescribed 200 mg in 1-2 doses on the first day of treatment, then 100 mg daily. In cases of severe infections, Unidox is prescribed at a dose of 200 mg daily throughout treatment.

For children 8-12 years old weighing less than 50 kg, the average daily dose is 4 mg/kg on the first day, then 2 mg/kg per day (in 1-2 doses). In cases of severe infection, Unidox is prescribed at a dose of 4 mg/kg daily throughout treatment.

Features of dosing for certain diseases

For infection caused by S.pyogenes, Unidox is taken for at least 10 days. For uncomplicated gonorrhea (excluding anorectal infections in men):

Adults are prescribed 100 mg twice a day until complete cure (on average within 7 days), or for one day they are prescribed 600 mg - 300 mg in 2 doses (the second dose 1 hour after the first).

For primary syphilis, 100 mg is prescribed twice a day for 14 days, for secondary syphilis - 100 mg twice a day for 28 days. For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg/day is prescribed, the course of treatment is 6-12 weeks.

Malaria (prevention): 100 mg 1 time per day 1-2 days before the trip, then daily during the trip and for 4 weeks after return; for children over 8 years old, 2 mg/kg 1 time per day.

The duration of prophylaxis should not exceed 4 months. Traveler's diarrhea (prevention) - 200 mg on the first day of the trip (in 1 dose or 100 mg 2 times a day), then 100 mg 1 time per day throughout your stay in the region (no more than 3 weeks).

Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prevention of leptospirosis - 200 mg once a week during your stay in a disadvantaged area and 200 mg at the end of the trip.

To prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg/day or 600 mg/day for 5 days for severe gonococcal infection. For children over 8 years old with a body weight of more than 50 kg - up to 200 mg, for children 8 - 12 years old with a body weight less than 50 kg - 4 mg/kg daily during the entire treatment period.

In the presence of renal (creatinine clearance less than 60 ml/min) and/or liver failure, a reduction in the daily dose of doxycycline is required, since this leads to a gradual accumulation of it in the body (risk of hepatotoxicity).

Pharmacodynamics

Broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, suppresses protein synthesis in the microbial cell by interacting with the 30S ribosomal subunit. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. aerugenes), Neisseria gonorrhoeae, Neis seria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Typhus exanthematicus, Escherichia coli, Shigella spp., Campylobacter fetus , Vibrio cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficilé), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).

As a rule, it has no effect on Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

Pharmacokinetics

Suction

Absorption is fast and high (about 100%). Food intake has little effect on the absorption of the drug.

The maximum level of doxycycline in the blood plasma (2.6-3 mcg/ml) is achieved 2 hours after taking 200 mg; after 24 hours, the concentration of the active substance in the blood plasma decreases to 1.5 mcg/ml.

After taking 200 mg on the first day of treatment and 100 mg per day on subsequent days, the plasma concentration of doxycycline is 1.5-3 mcg/ml.

Distribution

Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into organs and tissues, poorly into the cerebrospinal fluid (10-20% of the level in the blood plasma), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane.

Volume of distribution - 1.58 l/kg. 30-45 minutes after oral administration, doxycycline is found in therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissue, pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluids.

With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.

In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined.

Doxycycline crosses the placental barrier and is secreted into breast milk in small quantities.

Accumulates in dentin and bone tissue.

Metabolism

A small portion of doxycycline is metabolized.

Removal

The half-life after a single oral dose is 16-18 hours, after repeated doses it is 22-23 hours.

Approximately 40% of the drug taken is excreted by the kidneys and 20 - 40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations

The half-life of the drug in patients with impaired renal function does not change, because its excretion through the intestines increases.

Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in blood plasma.

Indications for use Unidox Solutab 100 mg 10 pcs. dispersible tablets

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory tract infections, including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema;
infections of the ENT organs, including otitis media, sinusitis, tonsillitis;
infections of the genitourinary system: cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophioritis as part of combination therapy; including sexually transmitted infections: urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea (as an alternative therapy), granuloma inguinale, lymphogranuloma venereum;
infections of the gastrointestinal tract and biliary tract: (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, traveler's diarrhea);
infections of the skin and soft tissues (including wound infections after animal bites), severe acne (as part of combination therapy);
other diseases: yaws, legionellosis, chlamydia of various localizations (including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (I stage. - erythema migrans), tularemia, plague, actinomycosis, malaria; infectious eye diseases, as part of combination therapy - trachoma; leptospirosis, psittacosis, ornithosis, anthrax (including pulmonary form), bartonellosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis;
prevention of postoperative purulent complications: malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) to areas where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

Contraindications

Hypersensitivity to tetracyclines;
pregnancy;
lactation;
age up to 8 years;
severe impairment of liver and/or kidney function;
porphyria.

Application of Unidox Solutab 100 mg 10 pcs. dispersible tablets during pregnancy and breastfeeding

Doxycycline penetrates the blood-placental barrier. Tetracyclines have an adverse effect on the fetus (slowing osteogenesis) and on the formation of tooth enamel (irreversible discoloration, hypoplasia). Due to this, as well as the increased risk of liver damage in the mother, tetracyclines are not used during pregnancy, except in cases where the drug is the only remedy for the treatment or prevention of particularly dangerous and severe infections (Rocky Mountain spotted fever, inhalation exposure to Bacillus anthracis, etc.). Before prescribing doxycycline to women of childbearing age, pregnancy should first be excluded. Doxycycline passes into breast milk. Due to its adverse effects on the fetus, doxycycline, like other tetracyclines, should not be used during breastfeeding. If the prescription of tetracyclines is necessary, breastfeeding is discontinued.

special instructions

There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.

Tetracyclines may increase prothrombin time; the use of tetracyclines in patients with coagulopathies should be carefully monitored.

The anti-anabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal renal function. However, in patients with renal failure, an increase in azotemia may occur. The use of tetracyclines in patients with impaired renal function requires medical supervision.

With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.

Due to the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.

Long-term use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).

To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

Impact on the ability to drive vehicles and operate machinery

The effect on the ability to drive vehicles, machines and mechanisms is unknown.

If you develop dizziness, blurred vision or double vision, driving vehicles or using machinery is not recommended. See Side effects - Nervous system disorders.

Overdose

Symptoms:

Increased adverse reactions caused by liver damage - vomiting, fever, jaundice, azotemia, increased transaminase levels, increased prothrombin time.

Treatment:

Immediately after taking large doses, gastric lavage, drinking plenty of fluids, and, if necessary, inducing vomiting are recommended. Take activated carbon and osmotic laxatives. Hemodialysis and peritoneal dialysis are not recommended due to low efficiency.

Side effects of Unidox Solutab 100 mg 10 pcs. dispersible tablets

From the gastrointestinal tract: anorexia, nausea, vomiting, dysphagia, diarrhea, anal itching, esophagitis, esophageal ulcer, dark coloration of the tongue. With long-term therapy, a deficiency of B vitamins may occur due to the suppression of the growth of vitamin B-producing bacteria in the normal intestinal microflora.

Allergic reactions: exacerbation of systemic lupus erythematosus, a syndrome similar to serum sickness, erythema multiforme, decreased blood pressure, tachycardia, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS syndrome).

From the skin: urticaria, photosensitivity, angioedema, anaphylactic reactions, maculopapular and erythematous rash, exfoliative dermatitis, Henoch-Schönlein purpura, photoonycholysis.

From the cardiovascular system: pericarditis.

From the liver: liver damage, sometimes associated with pancreatitis (with long-term use of the drug or in patients with renal or hepatic insufficiency), cholestasis.

From the kidneys: an increase in residual urea nitrogen, due to the anti-anabolic effect of the drug, worsening azotemia in patients with renal failure. Consumption of products containing citric acid while taking doxycycline may cause symptoms similar to Fanconi syndrome: albuminuria, glycosuria, hypophosphatemia, hypokalemia, and renal tubular acidosis.

From the hematopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the nervous system: benign increase in intracranial pressure (anorexia, vomiting, headache, tinnitus, tremor, papilledema), vestibular disorders (dizziness or instability), hallucinations, blurred vision, scotoma, double vision.

From the thyroid gland: in patients who have been receiving tetracycline antibiotics for a long time, reversible dark brown staining of the thyroid tissue is possible, in most cases not accompanied by a violation of its function.

From the side of teeth and bones: doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (the color of teeth irreversibly changes, enamel hypoplasia develops).

From the musculoskeletal system: arthralgia, myalgia.

Other:

Superinfection: candidiasis, glossitis, staphylococcal enterocolitis, pseudomembranous colitis, anogenital candidiasis, stomatitis, and vaginitis.

Drug interactions

Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by an interval of 3 hours.

Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.

When doxycilline is combined with bactericidal antibiotics that interfere with cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced.

Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.

Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.

The simultaneous use of doxycycline and retinol increases intracranial pressure.

Indications of the drug Unidox Solutab®

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

respiratory tract infections, incl. pharyngitis, acute bronchitis, exacerbation of COPD, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema;

infections of ENT organs, incl. otitis media, sinusitis, tonsillitis;

infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoophoritis as part of combination therapy), incl. sexually transmitted infections (urogenital chlamydia, syphilis in patients with penicillin intolerance, uncomplicated gonorrhea (as an alternative therapy), granuloma inguinale, lymphogranuloma venereum);

infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);

infections of the skin and soft tissues (including wound infections after animal bites), severe acne (as part of combination therapy);

other diseases (yaws, legionellosis, chlamydia of various localizations (including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (I stage. - erythema migrans), tularemia, plague, actinomycosis, malaria; infectious diseases of the eyes (as part of combination therapy - trachoma); leptospirosis, psittacosis, ornithosis, anthrax (including pulmonary form), bartonellosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis);

prevention of postoperative purulent complications;

prevention of malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) to areas where strains resistant to chloroquine and/or pyrimethamine-sulfadoxine are common.

When is it prescribed?

Unidox Solutab, the instructions indicate this, is prescribed for the treatment of various infectious and inflammatory diseases that are provoked by drug-sensitive pathogenic microorganisms.

A wide range of applications makes it possible to successfully treat diseases of the respiratory system and ENT organs. Indications for prescribing the medicine are infectious diseases of the genitourinary system and gastrointestinal tract. The effectiveness of Unidox Solutab 100 has been proven in the treatment of skin pathologies and in the prevention of purulent complications after operations.

A detailed explanation of the indications for the tetracycline antibiotic is contained in the instructions for use. It is the basis for prescribing the drug.

Side effects

From the gastrointestinal tract: anorexia, nausea, vomiting, dysphagia, diarrhea; enterocolitis, pseudomembranous colitis.

Dermatological and allergic reactions: urticaria, photosensitivity, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, maculopapular and erythematous rash, pericarditis, exfoliative dermatitis.

From the liver: liver damage during long-term use or in patients with renal or hepatic insufficiency.

From the kidneys: an increase in residual urea nitrogen (due to the anti-anabolic effect).

From the hematopoietic system: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the nervous system: benign increase in intracranial pressure (anorexia, vomiting, headache, papilledema), vestibular disorders (dizziness or instability).

On the thyroid gland: in patients receiving doxycycline for a long time, reversible dark brown discoloration of the thyroid tissue is possible.

From the side of teeth and bones: doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (the color of teeth irreversibly changes, enamel hypoplasia develops).

Other: candidiasis (stomatitis, glossitis, proctitis, vaginitis) as a manifestation of superinfection.

Reviews about Unidox Solutab

Reviews in gynecology. The drug has good reviews in the treatment of gynecological diseases, for example chlamydia . Patients who were prescribed the drug for chlamydia note that the antibiotic is easily tolerated and effective. Although sometimes side effects occur in the form of headaches and disruption of the digestive system.

Reviews for use against ureaplasma are also good, many are of the opinion that the drug is almost the only effective way to get rid of the disease.

Reviews of Unidox Solutab for acne. a dermatologist may prescribe antibiotics to treat acne For most patients, acne medication helps, but then other problems arise due to the medication's side effects. For many, following a therapeutic diet helped better than those taking an antibiotic.

Interaction

Due to the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.

When doxycycline is combined with bactericidal antibiotics that interfere with cell wall synthesis (penicillins, cephalosporins), the effectiveness of the latter is reduced.

Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.

Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in the blood plasma.

The simultaneous use of doxycycline and retinol increases intracranial pressure.

Analogues of Unidox Solutab

Level 4 ATC code matches:
Vibramycin

Doxycycline hydrochloride

Doxycycline

The most common analogues:

Doxycycline
Vidoccin
Vibramycin
Doxibene
Doxa-M-Ratiopharm
Tigacil

The price of analogues differs significantly from the original, most often it is lower.

Doxycycline or Unidox Solutab - which is better?

The main difference between the drugs is the fact that Unidox does not have such a strong effect on the stomach and does not cause side effects characteristic of Doxycycline ( stomach ulcer , gastritis ). Absorption of the active substance occurs in the intestines and almost 100% of the medicine is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.

What is the difference between Unidox and Unidox Solutab?

The prefix “Solyutab” in the name of the drug means that the tablet can be crushed and dissolved in water to prepare a suspension for administration. This method of taking the medicine is preferable for children.

Directions for use and doses

Inside, during meals, the tablet can be swallowed whole, divided into parts or chewed, washed down with a glass of water, or diluted in a small amount of water (about 20 ml).

Typically the duration of treatment is 5–10 days.

Adults and children over 8 years of age weighing more than 50 kg - 200 mg in 1-2 doses on the first day of treatment, then 100 mg daily. In cases of severe infections - at a dose of 200 mg daily throughout treatment.

For children 8–12 years old weighing less than 50 kg, the average daily dose is 4 mg/kg on the first day, then 2 mg/kg per day (in 1–2 doses). In cases of severe infections - at a dose of 4 mg/kg daily throughout treatment.

Features of dosing for certain diseases

For infection caused by S.pyogenes, Unidox Solutab ® is taken for at least 10 days.

For uncomplicated gonorrhea (except for anorectal infections in men): adults - 100 mg 2 times a day until complete cure (on average within 7 days), or 600 mg - 300 mg in 2 doses are prescribed for one day (second taken 1 hour after the first).

For primary syphilis - 100 mg 2 times a day for 14 days, for secondary syphilis - 100 mg 2 times a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealyticum - 100 mg 2 times a day for 7 days.

For acne - 100 mg/day; course of treatment - 6–12 weeks.

Malaria (prevention) - 100 mg 1 time per day 1–2 days before the trip, then daily during the trip and for 4 weeks after returning; children over 8 years old - 2 mg/kg 1 time per day.

Travelers' diarrhea (prevention) - 200 mg on the first day of the trip in 1 or 2 doses, then 100 mg 1 time per day during the entire stay in the region (no more than 3 weeks).

Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prevention of leptospirosis - 200 mg once a week during your stay in a disadvantaged area and 200 mg at the end of the trip.

To prevent infections during medical abortion - 100 mg 1 hour before and 200 mg after the intervention.

Maximum daily doses for adults are up to 300 mg/day or up to 600 mg/day for 5 days for severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg/kg daily throughout treatment.

In the presence of renal (Cl creatinine <60 ml/min) and/or liver failure, a reduction in the daily dose of doxycycline is required, since it gradually accumulates in the body (risk of hepatotoxicity).

Form of the medicinal product

The antimicrobial agent Unidox Solutab contains the active substance - doxycycline monohydrate. The release form of the drug is tablets. Various substances are additionally used for their production. Their list is given in the instructions for use of the drug.

Biconvex tablets have certain external signs that can be used to exclude counterfeit. They have a grayish-yellow or brownish tint. Blotches are visible on their surface. In addition, there is an engraving “173” and a risk on different sides. Tablets are packaged in blisters of 10 pieces.

special instructions

There is a possibility of cross-resistance and hypersensitivity to other tetracycline drugs.

Tetracyclines may increase PT; use of tetracyclines in patients with coagulopathies should be carefully monitored.

With long-term use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.

Due to the possible development of photodermatitis, it is necessary to limit exposure to insolation during treatment and for 4–5 days after it.

Long-term use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).

To prevent dyspeptic symptoms, it is recommended to take the drug with meals.

The specific effects on the ability to drive a car and operate machinery have not been studied.

What are the contraindications?

The main contraindication is hypersensitivity to tetracyclines and other components of the drug. It is prohibited to carry out drug therapy during the entire period of pregnancy. The greatest risks of developing pathologies in the fetus occur in the 1st trimester, when the placenta has not yet formed. The active substance can accumulate in bone tissue, which will disrupt mineralization processes and lead to unpredictable consequences.

For the treatment of children under 8 years of age, Unidox Solutab tablets, the instructions for use confirm this, are not prescribed. They should be abandoned if there are serious problems with the liver and kidneys. They are not prescribed for the diagnosis of porphyria. This pathology is hereditary, it is characterized by disorders of pigment metabolism and other pathological symptoms.