Pharmacodynamics and pharmacokinetics
The manufacturer of Nano-Botox cream, Belvi-Rus LLC, which produces this cosmetic product under control and under license (Orléans, France), positions it as an anti-wrinkle microemulsion that, thanks to its active ingredients, can cope with even deep expression wrinkles and damage the skin facial firmness and elasticity.
Hyaluronic acid in this product acts as a regenerative substance in relation to the human skin, where it participates in the processes of cell migration and proliferation, as well as in tissue hydrodynamics .
Acetyl hexapeptide-8 (argireline) is a unique peptide containing 3 amino acids (methionine, glutamic and arginine) that act similar to Botox (botulinum toxin). The effects of this substance are aimed at relaxing the facial muscles, which leads to a reduction in existing facial wrinkles and prevents the formation of new ones.
Dipalmitoyl hydroxyproline is a herbal ingredient that stimulates collagen and removes free radicals, which helps improve skin firmness, strength and elasticity, as well as hydration.
Peptides (palmitoyl pentapeptide-4 and palmitoyl tripeptide-5) promote the restoration of skin structural elements ( elastin , collagen , glycosaminoglycans and fibronectin ).
Ceramides , being natural skin lipids (fats), protect the face from the effects of external harmful factors ( toxins , allergens ), and also prevent the loss of by the epidermis , thereby preventing it from becoming excessively dry.
Shea butter (karite) has a positive effect on the synthesis of elastin and collagen , which improve skin turgor and increase its firmness and elasticity. The effects of this cosmetic oil help smooth out wrinkles, moisturize, soften the skin and improve complexion.
Phospholipids , containing many nutrients and vitamins , are the main ingredients of cell membranes. They increase the penetration of other active ingredients into the deep layers of the skin, soften the skin, protect it from dehydration, and are also able to integrate (replace) into damaged areas of the epidermal barrier.
Dipotassium glycyrrhizate has antioxidant properties and exhibits softening, moisturizing, anti-inflammatory, tonic and nourishing effects on the skin.
Marine collagen is closest in structure to human collagen and therefore is absorbed by the body as efficiently as possible. It is characterized by a positive effect on the functional state of the skin, helping to soften, moisturize, strengthen and regenerate. Replaces the loss of amino acids, nourishes and heals the epidermis, creates a protective film on the skin that levels out its flaws.
Superoxide dismutase is the main enzymatic ingredient in the antioxidant defense of the human body, protecting the skin from the negative effects of oxygen in active forms (free radicals).
pros
Low price in comparison with analogues.- Complete safety, while injections may cause infiltrates or allergies.
- Easy to use - no need to dilute or prepare anything, just rub into the skin.
- Painless.
- Low incidence of side effects.
- Nutritional effect.
- No complications.
- Suitable for almost any skin type.
- Provides a cumulative effect.
Instructions for use
The instructions for using this cosmetic product, given on its packaging, involve externally applying a small volume of rejuvenating serum to problem skin of the face and/or neck and rubbing it in with circular, gentle movements of the hands until completely absorbed. Before each procedure, the skin on which the microemulsion must be cleaned in the usual way for a particular person (washing, wiping, etc.) and dry.
The recommended course of use of the anti-aging serum is 14 days with its application twice every 24 hours (morning and evening).
Description of the procedure
Stages of botulinum therapy:
- Before injections, the face is thoroughly cleansed of dirt, sebum, and makeup.
- Application of anesthetic gel to relieve pain.
- The drug is prepared in accordance with the intended dosage regimen. The required number of units is calculated depending on the segment of the face in which the injection is given.
- Administration of injections according to the scheme.
- Compress for the prevention of edema and hematomas.
- Recommendations for skin care.
The procedure takes 20-45 minutes, upon completion the client quickly returns to normal life. After 3-5 hours, visible results are already visible. All that remains is to observe the changes and follow all the specialist’s recommendations.
Reviews about Nano-Botox
Currently, there are serious battles on the Internet around the cosmetic product Nano-Botox. Many women who want to get rid of wrinkles and restore their facial skin to its former firmness and elasticity discuss this product, trying to reliably find out its positive and negative properties. Reviews on forums about this microemulsion vary widely, and often completely negative reviews about Nano-Botox for the face are closely adjacent to an entirely positive assessment of the effect of this anti-wrinkle cream. In all this confusion, it is quite difficult to highlight real reviews about the Nano-Botox serum, bypassing advertising articles and videos, especially since it is possible to familiarize yourself with the official instructions for this cosmetic product only when purchasing it, for which, in turn, you need to order a microemulsion on this or another site. Thus, the question of whether Nano-Botox is a hoax or really a “panacea” for wrinkles remains open, which is confirmed by the rather cautious reviews of doctors who are in no hurry to make final conclusions about this remedy.
The conclusion that can be drawn based on the available composition of the Nano-Botox serum is that even if its active ingredients cannot restore the skin to its former youth, they most likely will not do any harm. Consequently, the necessity and advisability of purchasing this product lies entirely in the sphere of a person’s trust in such cosmetics.
A critical look at the effectiveness of the serum
If we assume that the product contains all the declared components, then even theoretically they cannot have an effect comparable to that of Botox. And the effect itself is associated with numerous contradictions.
At a minimum, argireline (even if it is included in the product) is much weaker as a muscle relaxant and when administered directly into the muscle. When applied to the skin, only a small part of this substance penetrates into the muscles, but the main thing is that with such an application it is impossible to predict its diffusion into neighboring muscles. This means that it is quite possible that facial expressions may be impaired and side effects may occur. Actually, it is precisely to protect against these consequences that injections are made, which allow you to very accurately and precisely immobilize the necessary muscle fibers. Simply applying the product to the skin will not achieve this effect - the product will “spread” over a large area and denervate different muscles.
Muscle relaxants simply applied to the skin of the face, rather than injected pointwise into a muscle, can denervate non-target muscles and lead to impaired facial expressions.
On a note
It is for this reason that Botox itself is still not used externally in cosmetology: it diffuses unpredictably under the skin and often immobilizes the wrong muscles that cause the formation of wrinkles. Moreover, you need to apply a lot of it, because only a small part of it will pass through the skin.
Simply put, if the manufacturer guarantees the absence of side effects, it means that the product does not contain muscle relaxants and is not capable of relaxing muscles and eliminating wrinkles. If a product can eliminate wrinkles, then it definitely cannot be used on its own without knowing which specific muscle fibers should be immobilized.
The instructions for use of Nano-Botox indicate that the microemulsion should be applied to areas of skin with wrinkles and rubbed in in a circular motion until completely absorbed. For a person who understands the principle of action of muscle relaxant substances, this means that the product does not contain components capable of producing a Botox-like effect, otherwise, with such use, the drug would be guaranteed to cause extensive immobilization of part of the face.
Therefore, the main effect that can be expected when using Nano-Botox is skin hydration, some toning through regular finger massage and aromatization. All this, by the way, is quite useful, including for fighting wrinkles, but you definitely don’t need Nano-Botox for this, and it’s enough to use any moisturizer or lotion.
Further, the lack of information about the manufacturer adds a bit of mistrust. According to advertising claims, the product is very effective, but its manufacturer does not at all seek to make a name for itself, and very little is known about it. Pharmacies indicate that Nano-Botox is produced by Belvi-Rus LLC, information about which cannot be found anywhere and which has no known other cosmetic products. And in some places they report that Nano-Botox is produced either in France or in Holland...
Again, in the photo of the packaging from a buyer from Ukraine the name is:
Review
My mother and I ordered it, she wanted to get rid of wrinkles, I wanted it for prevention. We thought that one bottle would be enough for a week, so we decided to order one for two. A consultant called us and said that the effect of one bottle for two people is not enough, if you use it correctly, you need much more. In general, she spoke convincingly, in the end my mother ordered 4 bottles for 1800 UAH, I ordered one bottle for 460 UAH. The package arrived, we opened it. Cute bottles containing a pinkish solution. The smell is pleasant. According to the instructions, the spray should be applied to skin with wrinkles twice a day. We apply. Unpleasant sensations - dry, tight skin, like after a harsh soap. It goes away in 1-2 hours. The bottle is designed for a week, in fact it lasts for two. My mother and I used it for two months, no effect. Not at all, I just washed my face with soap. No benefit, no harm, just over 2 thousand down the drain. Then I started reading and found negative reviews that people were writing that it was all a scam. Here, I’m sharing my experience. Maybe it will help someone save their money.
Olesya, Zhitomir
You need to understand that if Nano-Botox were even half as effective as the advertisement promises, the name of its manufacturer would already be thundering all over the world. The tiny startup Allergan, which produced Botox for the needs of surgeons and neurologists, became a billion-dollar corporation within a few years after discovering its ability to smooth out wrinkles.
After the discovery of the properties of Botox to smooth out wrinkles, the pharmacological company that produced the drug immediately became widely known throughout the world.
If the manufacturer of Nano-Botox had provided an effect similar to Botox, but which could be obtained at home without injections, today it would also be, if not one of the world's pharmaceutical giants, then certainly a noticeable large company. Instead, he is forced to promote his products through makeshift sites with second-rate advertising. This does not fit in with the image of the manufacturer of a revolutionary new cosmetic product.
By the way, certificates of conformity and information about the drug cannot be found on the Rospotrebnadzor website.
We have already said about the lack of positive reviews and the abundance of negative opinions from customers. In addition to this, none of the qualified cosmetologists use Nano-Botox: at least some, and they are definitely interested in attracting to their clinics those clients who are afraid to get Botox injections.
At the same time, a huge number of buyers complain that after using Nano-Botox they did not get the desired result. Moreover, many report that there is no effect at all after using the drug, and neither sellers nor manufacturer representatives respond to complaints and complaints.
Unbiased reviews indicate a complete lack of the declared effect from the use of Nano-Botox.
All this suggests that Nano-Botox is another deception, useful only to its manufacturer and sellers, and generating profits due to the hope of buyers that they can replace real Botox, avoiding the need for injections.
Be that as it may, Nano-Botox has, although not great, an advantage...
Nano-Botox price, where to buy
If you still decide to experience the effect of this anti-aging face cream and are looking for information about how much it costs and where to buy Nano-Botox in Ukraine, Russia or Belarus, then it is worth noting that in none of these countries It is almost impossible to buy Nano-Botox in a regular pharmacy. Today, purchasing this cosmetic product comes down to ordering the serum via the Internet on various websites selling medicines and/or cosmetics. Also, when discussing the purchase of this microemulsion, it is often advised to buy it on the official website, although even a quick look reveals that there are a great many such “genuine” representatives of Nano-Botox. To avoid purchasing a counterfeit, when ordering serum through online stores, be careful and use personally verified resources or, as a last resort, sites with a high trust rating.
The average price of Nano-Botox in online pharmacies is: in Kyiv – 798 hryvnia (with a discount of 399 hryvnia); in Moscow – 1614 rubles (with a discount of 990 rubles). The cost of this serum in Minsk should be clarified individually.
Which drug is more effective?
Let's compare the effectiveness of Botox and its analogue from South Korea.
Botox:
- Easily tolerated, complications are rare.
- Low effectiveness in eliminating deep wrinkles.
- The effect increases gradually from 2-3 days. Maximum result at the end of the second week.
- Frequent repeated injections form an addiction to the drug and reduce its effectiveness.
- The result lasts 6-8 months.
- Good lifting effect: the corners of the lips and brow ridges are raised.
- High price due to the popularity of the brand.
Botulax:
- Affordable price. Competitor in price even for domestic products.
- Peculiarities. The drug's production technology and components are similar to Botox.
- The duration of the effect is 4-6 months.
The general features of the drugs are targeted effects, preservation of natural facial expressions and gestures. The effect of the drugs does not extend to nearby tissues.
How does skin change after mesobotox?
Mesobotox leads to a noticeable disappearance of sagging: the skin is smoothed, tightened, and becomes elastic. The second very pleasant effect after the introduction of mesobotox is the effect of fullness, which enhances the result of the procedure.
Expert comment:
“Mesobotox is injected only into the dermis, where the muscle cells of the skin are located, and relaxes them. Since the skeletal muscles are not affected in any way, natural facial expressions are completely preserved .
This property of the procedure is especially appreciated by those whose appearance directly affects their professional success - actors, TV presenters, models, politicians and business coaches... People in public professions by occupation should have a fresh and expressive face without the effect of a frozen mask, which can often be obtained after classic Botox injection technique.
The effect of the procedure appears within 2–4 days and lasts from 6 to 8 months.”
Maxim Vasiliev, plastic surgeon.
Clinical researches
The effectiveness of Nano Botox has been confirmed by successful clinical trials. The purpose of clinical trials is to prove the versatility of the created product.
Based on the results of clinical studies, cosmetologists came to the following conclusions:
- Of course, the serum used successfully performs the following functions - nourishes, moisturizes, regenerates and rejuvenates the skin, cleanses it of toxins and protects it from aggressive environments;
- Under the influence of microemulsion, the skin becomes smoother and more elastic, the upper layer of the epidermis is smoothed;
- The serum helps to even out facial contours and eliminate wrinkles.
After applying Nano Botox microemulsion, wrinkles disappear, the skin acquires a healthy color and radiance.
