Biorevitalization of the face: what kind of procedure is it, the after effect and contraindications

From this article you will learn:

• biorevitalization: what kind of procedure is it, reviews,
• photos of patients before and after,
• injection and non-injection techniques,
• how much does biorevitalization cost - price for 1 procedure (for 2022).

Facial biorevitalization is a procedure for intradermal injection of high concentrations of active substances, which can significantly improve the appearance of the skin, increase its elasticity, as well as achieve a lifting effect and reduce the depth of wrinkles. Most often, hyaluronic acid, vitamins, microelements, amino acids are used for this, and in older age - components for intensive skin lifting, for example, peptides, DNA-RNA complexes and DMAE.

The composition of the drug is selected individually for each patient. The age of the patient, the condition of the facial skin, and, what is very important, the type of skin aging are taken into account. For example, for fine-wrinkle and deformation types of aging, completely different drugs will be indicated. An important problem is the training of specialists. How often, for example, do mesotherapists tell patients that capillary mesotherapy must be done before administering biorevitalizants? But in many cases, the severity and duration of the biorevitalization effect will depend on this.

Biorevitalization: photo of the procedure

Indications for biorevitalization –

• therapy for biological skin aging,
• photoaging therapy (including hyperpigmentation and rosacea),
• prevention of aging,
• wrinkles, thinning, decreased elasticity, dry skin,
• deterioration of the skin as a result of smoking (including the appearance of small vertical wrinkles on the lips).

Thus, the biorevitalization technique will allow you to improve the color and texture of the skin (especially for smokers), increase its elasticity, reduce the depth of wrinkles, and achieve a skin lifting effect. Additional effects of this procedure may include correction of hyperpigmentation, reduction in the severity of rosacea, as well as inflammatory elements of acne. The severity of a particular effect will directly depend on the composition of the chosen drug.

Biorevitalization (revitalization) of the face - what is it?

The development of this method was a real breakthrough in the field of cosmetology. Already after the first session, dramatic changes for the better are noticeable. The essence of the procedure is the introduction of hyaluronic acid-based products into various areas of the dermis. In addition to it, the composition may also contain other biologically active components.

Necessary drugs and devices

When carrying out the procedure, you need to be extremely careful, since the presented preparations differ in different concentrations of hyaluronic acid. In addition, they cannot be considered universal, since each is designed for a specific biorevitalization technique. The degree of impact of fillers and gels varies.

The most popular are:

• Surgilift. It comes in the form of a gel, which is intended for the preparatory stage before visiting a cosmetologist’s office to cleanse the face. Can be recommended before plastic surgery. Designed for administration using a device.

• Skin R. Has positively established himself in cosmetology circles. The drug has a pronounced rejuvenating effect. Some cosmetologists prescribe it with face-lifting properties, which are comparable in effect to plastic surgery.

• Ial-System. Highly concentrated drug (18 mg of hyaluronic acid per 1 g of product). Due to the high density, injection marks may be present.

• Restylane Vital. It is considered one of the safest, so it can be used at home. The main component is not of animal origin, which does not cause allergic reactions. The product spreads well and takes root in the epidermis.

• Uniderm Ultra. It can only be administered by injection. After use, you will experience the elimination of wrinkles, a beautiful even skin tone and elasticity.

Interesting point: Hyaluronic acid is extracted from human embryos, newborn animals or mature adults. It is as close as possible to human, so allergic reactions to the drug itself should not occur.

If you want to carry out biorevitalization at home yourself using a device, then you will need:

• gel hyaluronic acid;
• vitamin complex;
• moisturizer or lotion;
• device (special device or laser).

For deeper penetration of the gel into the epidermis, you can acquire devices whose operating principle is the effect of microcurrent on the skin.

There are the following device options:

• vacuum apparatus;
• microt device;
• laser;
• a device that emits radio frequency waves.

Regardless of which method of administration you choose, always check the ampoule or package for leaks and the product for compliance with the expiration date. Your beauty will depend on compliance with these rules.

We would recommend that you buy Gezaton Iris 708, SPA 777, Mezolight 9900, which operate on the basis of radio frequency waves, or E-Polation Mini, which produces electrical impulses.

All of them do a good job of absorbing hyaluronic acid into the skin. After the procedures, blood circulation improves, metabolism at the cellular level is restored and the elasticity of the skin improves.

It should be noted that the effect of infrared rays produced by the laser promotes the uniform distribution of hyaluronic acid and its deeper absorption. The device itself is quite expensive - prices start at 40 thousand rubles. Even if you buy a device, you need to be able to vary the effect of laser beams on the skin. The slightest carelessness and you could get burned. Therefore, do not take risks, but order a similar procedure in a beauty salon.

In order to restore your face to its former beauty and attractiveness using hardware, you need to carry out the procedure once a month. Injection of fillers under the skin is done much less frequently - 2 times a year. In any case, we recommend consulting with your cosmetologist.

What explains the effectiveness of the method

The condition of the skin is largely determined by the activity of special cells - fibroblasts. Their main function is to produce structural protein components (elastin and collagen). They form an elastic frame that supports all layers of skin tissue.

The effect of biorevitalization of the skin of the face and neck depends on hyaluron. The branched structure of the molecule helps to retain a large amount of water, thanks to which turgor (elasticity) is maintained, which serves to prevent the formation of wrinkles.

Improvement occurs after the first session and consists of:

• Normalization of moisture levels.
• Activation of the production of scaffold proteins.
• Acceleration of regeneration (renewal of cellular composition).

There is also stimulation of the natural synthesis of hyaluron, which significantly enhances and prolongs the rejuvenating properties of the technique.

Differences between biorevitalization and mesotherapy -

Mesotherapy and biorevitalization of the face and neck are very similar procedures and are performed by the same specialists - mesotherapists. So how are they different? When it comes to intensive rejuvenation of the face and neck (using high concentrations of active ingredients), the term “biorevitalization” is used. Mesotherapy uses lower concentrations of active components, and this procedure can be performed not only on the face, but also on the body.

Thus, when it comes to the correction of cellulite or local fat deposits on the body, or procedures are carried out to improve the condition of the hair and scalp, or to improve the condition of the skin of the face and neck (but with low dosages of active substances) - this is called the term “ mesotherapy". If intensive rejuvenation and lifting of the skin of the face/neck is required, then drugs with high concentrations of active substances are used, and in this case the terms “biorevitalization” or “bioreparation” are used.

For example, the concentration of hyaluronic acid (HA) in mesopreparations is usually only from 0.3-0.5%, which corresponds to 3-5 mg/ml, and in biorevitalization products it is usually from 1.5 to 2.0% (= 15-20 mg/ml). Accordingly, in the second case, the saturation of the dermis with moisture will be much more intense, and this will lead to a more noticeable lifting effect. It is also worth noting that low molecular weight HA (with a molecular weight of about 800 kDa) is usually used in mesotherapy, and high molecular weight HA (from 1800 to 3000 kDa) is used in biorevitalization procedures.

An important point is that mesopreparations are made on a water or sol basis (sol is a liquid gel), and biorevitalizants are produced in the form of viscous gels. This greatly affects the time of drug deposition in tissues. Those. if in the first case, the drugs quickly spread in the tissues and are quickly eliminated from them, then in the second case, a drug depot is created in the tissues (at the site of each injection) for a period of approximately 2-3 weeks. That is why it is customary to inject mesopreparations once a week, and biorevitalizants - usually once every 2-3 weeks. Such differences between mesopreparations and biorevitalizants affect not only the frequency, but also the required number of procedures.

When is biorevitalization needed?

The procedure can be performed between the ages of 25 and 50 years. The maximum result can be achieved up to forty - the older the patient, the lesser the effect of the drug will be. This is due to the depletion of resources for the synthesis of elastic proteins and a decrease in the number of fibroblasts. To compensate for them, you will need to use additional rejuvenation products.

Let's consider the indications for when facial biorevitalization can be done:

• To compensate for natural dry skin or caused by harmful factors (smoking, ultraviolet rays, negative temperatures).
• With pronounced pigmentation. It may occur as a result of congenital characteristics, exposure to sunlight, or metabolic disorders.
• With age-related skin changes.
• To correct puffiness and drooping eyelids.
• For spider veins on the face and neck. Usually the reasons for their appearance are disturbances in blood circulation and vascular tone.
• For recovery after plastic surgery, laser resurfacing.

What effect will be achieved after biorevitalization depends solely on the cause of cosmetic problems. For example, tissue injury, excessive work of the sebaceous glands, and other skin disorders are successfully eliminated with the help of revitalization. If acne appears as a result of hormonal imbalance, and dull complexion is the result of metabolic disorders, then the benefits of the procedure will be much lower.

Super thin injection needles Nanoneedle

Kurasen dermal biocorrector

Nanoneedles with ultra-thin walls 30G

Nanoneedles with ultra-thin walls 33G

Nanoneedles with ultra-thin walls 34G

The whole truth about the negative consequences of biorevitalization

Despite the fact that hyaluronic acid is hypoallergenic, side effects from the procedure still occur. They are expressed in the appearance of local redness and swelling. The higher the sensitivity of the skin, the stronger its reaction to microinjections. It is even possible that bruises and bruises may form, but such consequences only occur when the drug is administered too deeply. That is, if the procedure was performed in violation of the rules.

What to do?

To minimize the risk of complications, you should only consult a good doctor. This specialist must work in a prestigious clinic, have a diploma in medical education, a certificate confirming the right to work with a particular drug, documents for the products used and positive customer reviews.

Another unpleasant consequence of biorevitalization is the complete lack of a positive effect. That is absolutely a waste of time and money.

What to do?

Before starting therapy, tell your doctor in detail about the characteristics of your health. It is also important to obtain as detailed information as possible about proper recovery after the procedure. After all, some of your actions can harm yourself.

Advantages of the method

The main advantages of this method of rejuvenation include:

• The ability to correct the oval of the face, smooth out fine wrinkles, and activate the process of cell renewal.
• No need for lengthy preparation.
• The total duration is less than an hour.
• Minimal discomfort.
• Preservation of the result for a long time (subject to the doctor’s recommendations).

Facial biorevitalization also has disadvantages and contraindications:

• allergy to the components of the drug;
• presence of neoplasms;
• severe chronic and autoimmune diseases;
• diabetes mellitus in the last stages;
• active phase of the inflammatory process.

Relative ones include pregnancy, the period of breastfeeding, and the use of anticoagulants.

Carrying out at home

There are several ways to administer hyaluronic acid:

1. The use of fillers based on it, which are injected under the skin with syringes.
2. Hardware method.
3. A laser technique that promotes uniform distribution of the drug and deep penetration into the epidermis.

The introduction of hyaluronic acid through the use of syringes is considered the most effective method, but doing it at home (doing high-quality acupuncture and correctly calculating the dose) without medical education is very problematic.

You've probably come across an advertisement in the press and on the Internet that a cosmetologist will come to your home and administer injections painlessly with minimal consequences. We would like to note that in practice the opposite effect appears, which only aggravates the situation. There is absolutely no point in trusting people on the street, especially since your health and beauty are at stake.

You should not pay attention to marketing ploys for the following reasons:

• As a rule, would-be specialists do not have a medical education;
• if something goes wrong, you will not be able to receive proper assistance;
• if you incorrectly calculate the dose or administer an expired drug, the product may be unevenly distributed under the skin, giving your face a pronounced asymmetry;
• in case of an unfavorable outcome, it is very difficult to find the master and make him answer for the consequences.

Using a laser on your skin is much safer than injecting yourself. But the device itself costs fabulous money, unless you rent it.

The only thing that is acceptable at home is to apply a special product to the skin and apply microcurrent to deeply absorb hyaluronic acid into the epidermis. This device is relatively inexpensive and can be purchased online. After the procedure, the skin begins to look much better, and fine wrinkles disappear. The only disadvantage of this method of rejuvenation is the short-term effect.

Kinds

Hyaluronic acid can be administered in different ways. Depending on the method of administration, the cost and other features will differ. The simplest type of revitalization is injection. The degree of injury is minimal and affects only the superficial layers.

Injection biorevitalization

Revitalization is carried out under sterile conditions using modern proven drugs. The injection is administered deep into the dermis using a syringe equipped with a thin needle. Most often, a point technique is used (punctures follow each other at a distance of up to 1.5 cm).

Since the procedure is traumatic, it is performed in combination with local anesthesia. Together with a cosmetologist, it is important to choose in advance the correct method of how to do facial biorevitalization in order to eliminate contraindications and choose the best option. There are two main ones:

1. Manual. The specialist personally performs the injections, thereby reducing the amount of damage.
2. Hardware. The substance is administered with a special device. It has a more aggressive effect, the cosmetic product is distributed as evenly as possible.

Recovery takes 1-3 days, after this period the effect becomes clearly visible.

Non-injection biorevitalization

In this case, hyaluronic acid is introduced using auxiliary technologies. The risk of complications is minimal and no recovery is required after the session. The technique is divided into several varieties:

• Cryo-biorevitalization. Involves the use of liquid nitrogen.
• Ultraphonophoresis. The drug enters the skin under the influence of ultrasound.
• Iontophoresis. The substance penetrates the dermis due to galvanic current. It also stimulates metabolic processes and regeneration.
• Magnetophoresis. Hyaluronic acid is injected using magnetic waves.

Any of these options can be used if there are certain contraindications or for clients who are afraid of injections.

Laser biorevitalization

It is placed in a special category, since in addition to the drug, the laser radiation itself also has an effect. Due to this, it is possible to obtain the following results:

1. Improving microcirculation of blood and lymph. This provides an additional flow of oxygen and nutrients.
2. Reducing inflammation.
3. Increased production of scaffold proteins.
4. Correction of uneven microrelief and microscars from acne.

Using a laser, cosmetologists introduce low molecular weight varieties of hyaluronic acid. It penetrates the skin better and has an increased stimulating effect on fibroblasts.

When is non-injection (laser) biorevitalization recommended?

Non-injection biorevitalization is effectively used for:

• correction of wrinkles (especially around the eyes);
• deep moisturizing and nourishing of the skin;
• smoothing skin texture;
• improving microcirculation;
• restoration of the shape and volume of the lips;
• express lifting;
• recovery after peeling;
• treatment of acne (acne).

Contraindications to the procedure are minimal. Laser biorevitalization is not performed in case of hypersensitivity to the drug, pregnancy and in the case of autoimmune diseases.

Injection biorevitalization of the face

The technique can be divided into three stages. Before using it, you should definitely consult a specialist to exclude contraindications. For example, the technique cannot be used during pregnancy or in the presence of acute inflammatory diseases.

All stages take about 30-40 minutes, in some cases up to 1 hour. Moreover, most of the time (15-20 minutes) is spent waiting for the anesthetic to take effect. The injections themselves are performed in 10-15 minutes.

Preparation for the procedure

During the consultation process, cosmetologists conduct an external examination of the skin and interview the patient. Then the area of ​​influence, the optimal drug, and the method of its administration are selected. CURACEN has proven itself well - it is a multi-component product that has a complex restorative effect - reducing the rate of skin aging, preventing the appearance of wrinkles, preventing and treating pigmentation.

Progress of the procedure

Before visiting a specialist, you should avoid stress and alcohol consumption, and also not smoke a couple of hours before the session. Before biorevitalization and before injecting the substance, cosmetologists follow the following algorithm:

• Removing makeup from the client's face.
• Treat the skin with an antiseptic solution and mark the area where the composition is introduced.
• Application of local anesthetic.
• Injections of the drug are performed using Japanese NANONEEDLE needles. They make the procedure less painful and traumatic. This means that the rehabilitation period will go faster.

For women, it is advisable to carry out manipulations after the 14th day of the menstrual cycle. This is due to increased pain sensitivity and significant hormonal changes that are observed in most clients before this time.

Consolidate the result

After the end of the session, medicinal cosmetics with a soothing and anti-inflammatory effect are applied to the skin, and in the summer, cream with SPF. Next, the cosmetologist evaluates the patient’s condition and makes recommendations for further home care.

Biorevitalization of the face - what it is and why it needs to be done 05/07/2019 08:58

Wrinkles and dull skin - these problems begin to haunt many after 25 - 30 years, and with age the situation only gets worse. How to get rid of these troubles without resorting to expensive and dangerous surgical operations? With the help of biorevitalization - a modern and safe injection technique for restoring youth and beauty. It allows not only to slow down the aging process, but also, with regular maintenance therapy, to achieve a significant rejuvenation effect.

Carrying out

Injections can be performed using several (different) methods; the type is selected by the cosmetologist depending on the area and condition of the skin.

Papular technique

The drug is injected into the middle and superficial layers of the dermis. The needle is placed at an acute angle (about 15 degrees) and held with the cut facing upward. Small elevations form on the surface of the skin - papules, filled with the injected substance, which is gradually distributed in the surrounding tissues. When using products based on synthesized hyaluronic acid, the recovery process can take up to 3 days. When using the drug CURACEN - from 20 to 60 minutes. The consequences of such a cosmetic procedure are positive; biorevitalization is characterized by long-term preservation of the effect due to the slow resorption of the drug.

The average size of the tubercles is about 4 mm. In particularly delicate areas (around the eyes and lips), smaller papules are created, up to 2 mm in diameter.

Tubercular or micropapular technique

Injections are made with a 4 mm long needle at an angle of 45 degrees. Due to this, the active substances penetrate into the deepest layers of the dermis. Externally, the skin remains smooth, only traces of injections are visually visible.

Linear-retrograde technique

The essence of the technique is to introduce the composition with a long needle (up to 13 mm), which, after puncture, is carried parallel to the surface of the skin through the middle layers. On the reverse movement of the syringe, the active substance is injected.

By using this technique, specialists are able to reduce the number of injections, and the deep penetration of the needle additionally stimulates the regenerative processes of the skin. How long the effect of facial biorevitalization in this way will last largely depends on the skill of the cosmetologist, the individual characteristics of the patient and home care. On average, this period ranges from 6 months to 1 year.

Side effects

The procedure is low-traumatic and the unpleasant effects after it are temporary and pass quickly. Side effects may include:

• papules - appear at puncture sites and dissolve very quickly, leaving no traces;
• hematomas - can appear in people with fragile blood vessels. They also disappear without a trace within a few days;
• erythema and swelling - redness of the skin caused by an intense rush of blood to the affected area. It happens to everyone and goes away quickly. It is a sign of activation of regenerative processes in the skin;
• soreness. The skin has undergone multiple injuries, so a slight painful reaction is normal.

Usually all unpleasant phenomena disappear within two days, depending on individual characteristics. If after this time they do not disappear or their intensity increases, be sure to consult a doctor.

Why is capillary mesotherapy needed?

This is a good way to prepare for revitalization and other cosmetic procedures, allowing you to significantly increase microcirculation, accelerate lymph flow, increase blood flow, and reduce swelling. It is prescribed for:

• Severe sagging skin (ptosis).
• Severe swelling.
• Large-scale age-related changes.

For capillary mesotherapy, cosmetologists use vascular preparations. They are introduced first into the cervical-collar region, slowly moving towards the earlobes, collarbones, and submandibular area. Next, injections are made along the tension lines. Usually 1-2 sessions are enough, but their number can increase to 4-5 if problems in this area are severe.

How to prepare for biorevitalization

There are several important rules for preparing for biorevitalization; a good specialist will definitely tell you about them:

3 days before injections, you should not take aspirin or other blood thinning medications. If you neglect this rule, during injections there is a higher risk of bruising and bleeding, and the skin will take longer to heal.

For the same reason, it is advisable to exclude alcohol, energy drinks and tonic drugs on the eve of the procedure. Such as ginseng and ginkgo biloba.

Plan the procedure for a weekend or vacation, as it will take you 2 to 5 days to restore your appearance. In addition, alcohol is not advisable after the procedure, so do not do biorevitalization on the eve of possible celebrations.

How effective is it?

In the photo above you can see the effect of facial biorevitalization before and after the procedure. It lasts quite a long time, the specific period depends on the condition of the client’s skin, the severity of the problems, heredity, lifestyle and other factors. On average, one session lasts 6-12 months. To improve the results, you can carry out additional manipulations, their number will depend on the goal:

• Preventive – 1-2 sessions are enough.
• Medicinal – less than 5 is required.

The interval between them is determined by a specialist, usually the interval is about 1 month. How often biorevitalization is done after the main cycle again depends on the recommendations of a specialist. Usually one procedure is prescribed every six months, this allows you to maintain youthful skin for a long period.

Facial biorevitalization: before and after photos, effect

You will have great difficulty finding real photos before and after biorevitalization, because... Cosmetology clinics post only cases of the most successful procedures, or simply take photographs of patients after hardware rejuvenation techniques, passing them off as biorevitalization procedures. The following 2 photos are from an independent clinical study. Each patient was administered 2.0 ml of Restylane Vital during 1 procedure. The course of treatment consisted of three procedures done with an interval of 4 weeks.

Biorevitalization: before and after photos (course with HA mono-drug)

As you can see: the effect of therapy with a mono-drug of hyaluronic acid in patients aged 35 and 46 years is either minimal or not noticeable at all. As we said above, patients over 30 years old need other drugs containing vitamins, amino acids, microminerals, antioxidants, and 40-45+ also nucleotides, peptides and growth factors. What do you think: will patient reviews for such facial biorevitalization be positive? It is unlikely that cosmetology clinics will post such photographs.

Example No. 2 –

The following photos were taken by cosmetologist Victoria Petrovskaya. The patient underwent a course of 4 procedures, once every 2 weeks. At the beginning of each procedure, lymphatic drainage vascular injection was first performed with the drug “GAG Complex DVL Capyl formula”, then “Hydro Line P-Anti-wrinkles formula” - for the periorbital area, and “Hydro Line Peptide formula” - for all other areas of the face. Photos were taken after the second procedure. Those. Each procedure used the same 3-drug regimen.

Example No. 3 –

The following photos were taken by cosmetologist A.Yu. Voropaeva. The patient underwent a course of 4 procedures, once every 10-14 days. At the beginning of each procedure, lymphatic drainage vascular injection was first performed with the drug “GAG Complex DVL Capyl formula”. Then, different biorevitalizants were used in each procedure -

1. 
   "Nucleospire Revitalizing Complex A"

2. "Nucleospire DNA-RNA 2%",
3. "Nucleospire Revitalizing Complex A"
4. "Nucleospire DNA-RNA 2%".

Example No. 4 –

The following photos were taken by cosmetologist Irina Pyagai. The patient underwent a course of 8 procedures, once every 10 days. At the beginning of each procedure, lymphatic drainage vascular injection was first performed with the drug “GAG Complex DVL Capyl formula”. Different biorevitalizants were used in different procedures -

1. 
   "Nucleospire Revitalizing Complex A"

2. "Nucleospire Revitalizing Complex B formula",
3. "Nucleospire DNA-RNA 2%",
4. "Nucleospire Revitalizing Complex B formula",
5. "Nucleospire DNA-RNA 2%",
6. 7. 8. procedures – “Nucleospire DNA-RNA 1% DM Peptide formula”.

What you need to know about drugs

The exchange of hyaluron occurs quite quickly; without additional stabilization, it is absorbed in 1-2 days. If you give it a gel-like consistency, it will be possible to form a depot in the tissues, which will significantly prolong its resorption. To further increase the period of exposure, the substance is subjected to chemical stabilization, which significantly lengthens the decomposition time.

What facial biorevitalization gives depends on the type of drug used in cosmetology. There are two of them:

1. Low molecular weight. It retains less water, but small molecules act as signals, stimulating the work of fibroblasts and accelerating the natural regeneration of the skin. Significantly improves the overall condition of the skin and has an increased anti-aging effect.
2. High molecular weight. Provides a high degree of moisture retention, significantly increases turgor, and promotes rapid smoothing of shallow wrinkles.

Depending on the composition of the drugs, they are divided into:

• Monocomponent. Contains one active ingredient (hyaluron). Inexpensive, well suited for slowing down age-related changes under the age of 35, in the absence of other health problems. Allows you to normalize the level of moisture in tissues and eliminate fine wrinkles.
• Combined. They contain vitamins, microelements, and other useful compounds. Well suited for women 35-45 years old who do not have serious skin health problems. The drugs eliminate pigmentation and reduce the degree of photoaging.
• Powerful biorevitalizants. They contain many active components, such as peptides, various growth factors, amino acids.

Among the drugs is CURACEN from the Japanese manufacturer Japan Bio Products. It allows you to significantly reduce the rate of cellular aging, compact and even out the surface layers of the epidermis. This is achieved by enhancing the synthesis of its own structural proteins, such as collagen and elastin.

When choosing a suitable product, be sure to consult a cosmetologist. Cosmetologist specialists can correctly assess the condition of your body, indicate indications and choose the most effective and safe product.

Anti-age drugs

Bb Laboratories – Hyaluron-elastin-collagen extract

Laennec – solution for injection

Curacen Essence (20 fl x 2 ml)

Two-phase placental serum concentrate

How to choose a drug for biorevitalization -

Preparations for biorevitalization are currently produced by countless companies.
One of the main components for these purposes are hyaluronic acid (HA) molecules. Typically, the lifespan of chemically unmodified (unstabilized) HA molecules is only 24 to 48 hours. However, biorevitalizants are produced in the form of a viscous gel, which allows even unstabilized HA to be deposited for a slightly longer period, reducing the rate of its destruction. The properties of the drug are very dependent on the molecular weight of the HA chains. High molecular weight HA (from 1500 to 3300 kDa) moisturizes the skin well, but does not have a stimulating effect on fibroblasts. Low molecular weight HA has a stimulating effect on fibroblasts and angiogenesis, but rather weakly moisturizes tissues. At the same time, low-molecular HA is destroyed faster in the skin than high-molecular HA (unless, of course, it has been chemically modified). For example, the preparation “Ial-system ACP” contains stabilized low-molecular HA with a molecular size of 200 kDa.

According to the manufacturer, the degradation period of HA in this drug is 10 days, and given the size of the molecules, one can immediately understand that the drug mainly has a stimulating effect on fibroblasts, activating collagen synthesis in them, but the moisturizing effect of such a drug will be less pronounced than if we will use a drug with high molecular weight HA with a molecular size of, for example, 1800 kDa or more. Next we look at the percentage of HA content in the drug. For drugs with unstabilized HA, its optimal concentration is 1.8-2.0%, but if we are talking about drugs with stabilized HA, then 1.4% is enough.

Important: modern data suggests that preparations with hyaluronic acid should not be used more than once a month, because frequent administration of high concentrations of HA leads to - 1) increased production of the enzyme hyaluronidase, which accelerates the destruction of its own HA synthesized by fibroblasts, 2) enhances the activity of metalloprotease enzymes that destroy the intercellular matrix. Those. it turns out that you inject too much HA into the dermis, and the body reacts to this with a surge in the production of hyaluronidase, which will rapidly destroy not only the biosynthetic HA you introduce, but also its own endogenous HA produced by fibroblasts.

Therefore, it is worth using biorevitalizants with HA no more than once a month, alternating them, for example, with nucleotides. Or another option is to use biorevitalizants with stabilized HA, which has the property of gradually releasing chains of active hyaluronic acid without creating excessively high concentrations of active HA molecules in the tissues over a short period of time. Such drugs act gradually and over a longer period of time, and are usually administered once every 3-4 weeks. Examples of drugs are “Restylane Vital”, “Juvederm Hydrate”, “HyalRepair”, etc.

Mono-preparations with hyaluronic acid –

Below we give an example of the most famous monopreparations with hyaluronic acid. Please note that in any case it makes sense to take such drugs only up to 30-35 years of age. After this age, it is impossible to achieve good skin lifting or intensive rejuvenation using HA alone. More or less the effect will be noticeable only after a course of 4-5 procedures, and then only if your skin is in relatively poor condition. These drugs will not be particularly effective in case of photoaging, because These do not contain a complex of components to relieve oxidative stress.

• Restylane Vital and Restylane Vital Light (Sweden) are the first biorevitalizants in which the technology of chemical modification of HA (i.e., its stabilization) was applied. The preparations contain only 2% and 1.2% hyaluronic acid, respectively, and are used in patients with finely wrinkled type of facial aging: Restylane Vital - for more mature skin, and Restylane Vital Light - to prevent aging of younger skin. Reviews: these drugs are of high quality, but their composition is outdated, and they are suitable for no more than the prevention of age-related changes, and then only with a stretch.

• Juvederm Hydrate (USA) – contains 1.35% stabilized hyaluronic acid + antioxidant mannitol. The antioxidant is quite weak, so the drug is not very suitable for the treatment and prevention of photoaging. Reviews: in our opinion, Juvederm Hydrate should be used only for the prevention of aging in patients with fine wrinkles, and no older than 30 years. A course of at least 3-4 procedures performed once every 3 weeks will be more or less effective.
• The drugs “Ial-system” and “Ial-system ACP” are a line of two biorevitalizants produced in Italy. The drug "Ial-system" contains 1.8% of unstabilized low molecular weight hyaluronic acid (molecule size only 200 kDa). Accordingly, its effect occurs quickly, but will not be too long-lasting, and besides, such a drug moisturizes the skin less - compared to drugs based on high molecular weight HA. Available in 0.6 or 1.1 ml syringes.
  The second drug is “Ial-system ACP”. Available in 1.0 ml syringes and containing 2% partially stabilized low molecular weight HA (molecule size also 200 kDa). According to the manufacturer's information, HA remains in the skin a little longer - about 10 days, but this, of course, is still significantly less than the above-mentioned drugs from other brands. Reviews: in our opinion, Ial system biorevitalization is optimal only for the prevention of aging in patients no older than 35 years.

Combined preparations with HA (cocktails) –

The group of these drugs is so numerous that we will present only one of the many options - the Revofil Aquashine line of affordable drugs (made in Korea). Available in 2.0 ml syringes.

• Biorevitalizants Revofil Aquashine - the first option is “Aquashine”, containing unstabilized high molecular weight 1.5% HA, peptides, amino acids, vitamins and minerals, coenzymes (56 components in total).
  In our opinion, it is better to use in patients 35+; it gives a good lifting effect when used as a course. The second option is “Aquashine BR”, which additionally adds peptides that lighten the skin, and therefore it is well suited for hyperpigmentation, for example, for aged skin 45+, as well as for the treatment and prevention of photoaging. “Aquashine BTX” – suitable for ages 30+. It also has a similar composition, but peptides are additionally added to it, the effect of which is similar to Botox®, i.e. smooth out small facial wrinkles. Aquashine biorevitalization reviews: these drugs are suitable for patients with moderate age-related changes. Not suitable for patients with deformational/edema type of aging.

Powerful biorevitalizants for aging skin –

If your age is 40-45+ and you need a noticeable lifting effect and reduction in the depth of wrinkles, then hyaluronic acid, vitamins, minerals, amino acids and antioxidants alone are no longer enough. This requires nucleotides (DNA-RNA complexes), as well as peptides and growth factors. At this and even more so at an even more mature age, the dermis contains a significantly smaller number of fibroblasts, not to mention their activity. And if there are almost no fibroblasts, then there is nothing to stimulate. This is especially true for postmenopausal women.

• Nucleotide-based drugs – an example is NucleoSpire DNA-RNA from Mesopharm®. It contains nucleotides in a concentration of 2% and is available in syringes of 1.3 and 2.0 ml. Reviews: the drug gives a delayed but pronounced lifting effect, stimulates collagen production, and is used to correct hyperpigmentation, chrono- and photoaging. Suitable for intensive rejuvenation, can be used periodically in patients 35+ and regularly after 40-45 years. Suitable also for patients with deformational (edematous) type of skin aging. A similar drug based on nucleotides is Plinest (Italy). These drugs do not work for young people.

• “Meso-Wharton P199” - this drug contains not only nucleotides, vitamins (A, E, C, group B), trace elements and antioxidants, but also high molecular weight 1.5% hyaluronic acid (with a molecular size of 3300 kDa). This drug contains growth factors, as well as peptides that stimulate the proliferation of fibroblasts and stem cells in the dermis, and also enhance the production of new collagen by fibroblasts. Not for deformation/edema type of aging.

• The “HYALREPAIR” line – biorevitalizant “Hyalrepair -02” contains 1.4% stabilized HA, vitamin C and the main amino acids involved in collagen synthesis, these are proline, glycine and lysine. An excellent product for loose, finely wrinkled skin. The drug “Hyalrepair -04” - in addition to the same hyaluronic acid, contains vitamin C, glutathione and cysteine. This drug is well suited for the treatment of photoaging, copes well with the network of fine wrinkles, hyperpigmentation and rosacea. The course of these drugs usually consists of 3 procedures at intervals of 3 weeks.

• “Nucleospire Revitalizing Complex A” is a good biorevitalizant based on 1.8% unstabilized HA, with a large amount of antioxidants (vitamin C, glutathione, thioctic acid, coenzyme Q10), vitamin B5. This composition perfectly relieves oxidative stress after sun exposure, helps moisturize the skin, lighten hyperpigmentation and prevent its formation. Those. this drug is good for photoaging, optimal before and after vacation to hot countries. You can have 30+ regularly (and even 25+, but not often).

• 
  “Nucleospire Revitalizing Complex B” (Hydro Line Extra) is a good biorevitalizant also based on 1.8% unstabilized HA, contains 19 amino acids, all B vitamins, microminerals, and the antioxidant glutathione. If the previous drug is used for the prevention and treatment of photoaging (including at a moderately young age), then this drug is for aging skin and is intended to stimulate collagen production. Naturally, it is not as effective as Meso-Wharton P199, but it also costs 2 times less.

Important : for aging skin, only a course of biorevitalization (from 3 to 7 procedures) can give a good effect. Most often, the course is carried out not with one particular drug, but with a combination of several, and their choice for each woman will be individual.

Complications and precautions

Side effects for this technique are uncharacteristic and are observed extremely rarely. They usually appear as:

• Allergies to anesthesia or drug components.
• Microhematoma. The number of subcutaneous hemorrhages depends on the characteristics of the skin, the condition of the capillaries and microarteries.

There are also cases of infection penetrating into the dermis. Such situations arise when aseptic rules are not observed during the procedure or subsequent care is improper. If all standards and recommendations are followed, the likelihood of infection is zero. A consultation with a specialist dermatologist will help you decide whether biorevitalization is worth doing.

Avoiding negative consequences is quite easy. To do this, strictly follow medical recommendations, including:

• Do not touch your face for 24 hours after the session.
• Do not wear makeup for 48 hours.
• Avoid physical and mental stress, stress for 2 weeks, avoid going to the bathhouse or public swimming pools.
• Avoid drinking alcohol.

When washing, you need to use gentle cleansers that do not dry out the skin. It is also necessary to use an antiseptic recommended by a doctor, regularly treating the dermis until the injection marks are completely healed, and drink the recommended amount of water.

Now you know the basic information about facial biorevitalization and understand that this procedure helps get rid of wrinkles, significantly slowing down age-related changes in the skin. To avoid negative consequences, it is important to use certified drugs. Entrust the care of your health to specialists.

What it is

Biorevitalization is the introduction of hyaluronic acid under the skin, which reacts with cell receptors, ensuring a better process of their regeneration. As soon as the product penetrates the deep layers of the epidermis, it begins to attach water molecules. After this, the liquid is absorbed by the cells, which helps normalize metabolism and restore the skin.

The word “biorevitalization” is translated as:

• “bio” - natural;
• "re" - return;
• "vita" - life.

Thus, the concept implies the return of beauty and youth to your skin. It can be carried out for preventive purposes when you begin to notice wrinkles and deterioration in the condition of the epidermis. At home, applying the gel and treating the skin with a device as preventive measures to prevent aging is carried out once every three weeks.

But in most cases, the procedure is resorted to when age-related changes on the face become noticeable. If you follow all the cosmetologist’s recommendations and complete the course in full, you will see how fine wrinkles are eliminated and your skin glows with health.

The cost of the service in salons leaves much to be desired - on average you will pay 3–3.5 thousand rubles for one injection, and a whole course of therapy will cost you 25 thousand rubles. Of course, you don’t want to say goodbye to your monthly salary at all. But there is an alternative that will allow you to regularly rejuvenate - purchasing a device (for example, Gezaton) and a special gel containing hyaluronic acid.

Interesting point: Hyaluronic acid is produced by our body independently. After 25 years, its amount begins to decrease, which leads to the loss of elasticity of the skin and the formation of wrinkles. Biorevitalization injections just make up for its deficiency. They promote the body's production of elastane and collagen fibers.

Possible complications

Any procedure using various synthetic and organic drugs via injection has the potential for complications. This is due to both unaccounted for contraindications and delayed allergic reactions, as well as improper care after the procedure or the unprofessionalism of the cosmetologist.

Recovery after biorevitalization is quite fast. Pallor or redness of the skin and swelling may occur, but these are temporary side effects. The most important aspect in skin care is to prevent infection of microdamages after injections.

As for complications, they can be:

• Early ones, which appear immediately after the injection;
• Delayed, which occur after several days.

According to severity, complications are divided into mild, moderate and severe.

Serious complications include :

• Impaired sensitivity of the skin;
• Blockage of blood vessels;
• Tissue death;
• Tissue compaction;
• Tyndall effect;
• The appearance of nodes on the surface of the skin;
• Connective tissue growths;
• Hyperpigmentation and depigmentation.

Despite all the possible complications, biorevitalization remains one of the popular and effective methods of rejuvenation.

When preparing the material, consultation was carried out by:

Ekaterina Smirnova (dermatologist). Certified specialist with 20 years of experience. He is engaged in the diagnosis and treatment of dermatological diseases, and removes tumors. Proficient in injection cosmetology techniques for the face and body.

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Precautionary measures

Even regardless of where the procedure will take place (at your home or in an expensive salon), you must take into account the characteristics of your body. If you do not follow a considerable list of contraindications, you risk not improving the condition of your face, but only leading to the formation of allergic reactions.

The following contraindications exist:

• dermatological diseases on the skin of the face, as well as the presence of inflamed acne at injection sites;
• elevated temperature, which indicates the body’s struggle with some ailment (it does not need unnecessary stress);
• autoimmune diseases that are inherited (for example, psoriasis);
• pregnancy and breastfeeding;
• the presence of age spots, warts and large moles in places where fillers are required;
• oncological diseases;
• serious chronic diseases, in particular renal and liver failure;
• problems with the functioning of the heart and circulatory system;
• the presence of small wounds on the skin of the face;
• tendency of the dermis to scar;
• taking anticoagulants.

If you are planning to administer the serum under the skin yourself, we recommend that you consult with your doctor.

Failure to comply with contraindications and sterility of the procedure can lead to:

• swelling;
• bruising;
• redness of the skin;
• introduction or spread of existing infections;
• long healing of injection marks;
• itching at the injection sites;
• exacerbation of dermatological diseases;
• facial asymmetry.

What to do if the result is not satisfactory

Some women who undergo biorevitalization do not notice rejuvenation even after a month. You should know that in most cases the effect is visible in dry skin types and fine wrinkles.

If you have serious age-related changes, then this procedure will not be able to overcome them.

If you are dissatisfied with the result, we recommend that you contact a cosmetologist who will select the appropriate drug for you and administer it efficiently.

What should not be done after biorevitalization?

After biorevitalization, the cosmetologist always gives recommendations on what should be avoided after the procedure and what care is required. These rules must be strictly adhered to, since the outcome will depend on this.

After biorevitalization you cannot:

• Touch the skin of the face for 3-4 hours to avoid infection of the papules;
• Smooth out or squeeze out the formed papules;
• Use any cosmetic products for about 3 days;
• Sit for a long time with your head down (which often involves work), as tissue swelling may develop;
• Be exposed to sudden temperature changes;
• Massage your face or do facial exercises;
• Scratch papules. If itching occurs, you should take an antihistamine;
• Do sports for about 3 days and other physical activities.