Birch tar 40ml liquid for external use

Treatment of psoriasis with tar

Birch tar

Tar is a product of wood distillation . To obtain it, wood is heated at a temperature of 500-1050? C without access to oxygen.

Since ancient times, tar has been used for various purposes:

• as a component of drugs;
• for the production of cosmetics;
• in the meat industry;
• as a lubricant for parts;
• in gardening;
• in the chemical industry.

Birch tar is used in medicine .

Birch tar for psoriasis

Birch tar is most often used in medications against psoriasis.

It is used externally as part of ointments with 3-5% tar content. And also pure tar, applied in a thin layer. In any case, before use, you need to consult a doctor and monitor the condition of your skin to avoid allergic reactions.

Sometimes birch tar is taken orally for psoriasis, 1-10 drops per day. Reviews about this application are mixed:

Review from user Pol

Today, psoriasis is considered one of the most common chronic dermatoses. According to various sources [1], this disease affects from 0.2 to 8% of the world's population.

The onset of the disease varies among different patients. Provoking factors may be skin trauma, stress, the use of certain medications, alcohol abuse, infectious diseases (especially those caused by streptococcus and viruses), etc. [2, 3].

Men and women suffer from psoriasis equally often, but in girls, as a rule, psoriasis occurs at an earlier age: thus, the first signs of the disease appear in girls at the age of 16-20 years, and in men - at 18-32 years [4]. The high probability of manifestation of the psoriatic process remains at the age of 40 to 50 years [5]. The urban population gets sick much more often than the rural population, which is apparently due to an unfavorable environmental situation, an accelerated pace of life, various stressful situations and other negative psycho-emotional factors [6]. More often, at the beginning of the disease, there are few rashes; they are characterized by a monomorphic rash in the form of papular elements with a diameter of 1-3 mm to 2-3 cm or more, pink in color, covered with silver-white scales. As a rule, at this stage, the severity and prevalence of the psoriatic process is assessed as mild (PASI≤10). Efflorescence can persist for a long time in the same places, especially on the scalp and in the area of ​​large joints. At this stage, as a rule, treatment of psoriasis does not cause great difficulties, and it is quite enough for the patient to prescribe an appropriate diet, carry out restorative measures and external therapy [7].

For mild psoriasis, emollients and moisturizers are most often used, combining them with other active local agents. Keratolytic drugs reduce the severity of hyperkeratosis and soften psoriatic scales, which in turn facilitates their removal. Like emollients, keratolytic agents are also usually combined with other drugs. Various dosage forms of glucocorticosteroids (GCS) are most often used to treat psoriasis, but their systemic absorption leads to a number of serious side effects.

The use of retinoids for 12 weeks shows good clinical efficacy, and it can be increased when used together with GCS.

During the development of the disease, with an increase in the number of elements and their peripheral growth, the papules merge and form plaques of various sizes and shapes. At this moment, psoriatic lesions are characterized by a high degree of prevalence, severity of erythema and infiltration, which aggravates the patient’s condition. As a rule, the severity and extent of the psoriatic process (PASI) is assessed as moderate (10≤PASI≤30) or severe (30≤PASI≤72). The favorite localization of psoriasis is the extensor surfaces of the extremities, especially in the area of ​​the elbow and knee joints. The rash may affect the skin of the torso; The scalp is often affected.

Treatment of psoriasis is a complex therapeutic task [8]. In accordance with the pathogenetic processes, therapy for psoriasis is aimed at eliminating inflammation, suppressing the proliferation of epithelial cells, and normalizing their differentiation. In many cases, therapeutic measures can be successful, since there are a number of therapeutic methods for this dermatosis, but, unfortunately, all these measures provide only a temporary effect [9]. Pharmacotherapy and phototherapy can clear the affected skin and relieve unpleasant symptoms, but remission is usually short-lived and most patients experience a recurrence of the disease within a year.

For the treatment of moderate and severe psoriatic process, systemic therapy is prescribed: phototherapy, the use of vitamin A analogues and various options for immunosuppression.

Phototherapy blocks DNA replication, reducing skin cell proliferation; This method is quite effective, but is associated with a risk of developing skin cancer, which is why it is prescribed to patients over 50 years of age with intensely disabling psoriasis.

Vitamin A analogues are mainly prescribed for the treatment of severe and rare forms of psoriasis. These drugs have anti-inflammatory properties that reduce skin cell proliferation. However, their use is also associated with severe adverse events, including liver damage and embryonic defects.

Psoriasis is a multifactorial disease. Undoubtedly, changes in the immune system, either genetically determined or acquired under the influence of external and internal factors, play a large role in its pathogenesis.

Immune system disorders are detected both at the cellular and humoral levels and consist in the activation of immunological reactions, accompanied by changes in the content of immunoglobulins of the main classes, circulating immune complexes, the pool of lymphocytes in the peripheral blood, B and T populations and subpopulations of lymphocytes, cells killers, phagocytic activity of segmented leukocytes. To normalize these processes, various drugs belonging to the group of immunosuppressants are used.

Methotrexate is an analogue of folic acid, an inhibitor of DNA synthesis and has the ability to stop cell division. Methotrexate is usually prescribed to treat very severe forms of psoriasis that cannot be treated with other drugs, but its use is associated with the suppression of all dividing germs and is associated with liver damage.

Immunosuppressants such as cyclosporine have a selective effect on T cells. Cyclosporine is commonly used in the treatment of severe scaly psoriasis, but its use is limited to the treatment of patients with resistant psoriasis due to adverse effects such as renal failure, paresthesia and hirsutism.

In recent years, genetically engineered drugs—monoclonal antibodies (MAbs)—have become widely used for the treatment of psoriasis. The names of drugs created on the basis of MAT reflect their structure and basic properties. Thus, drugs with the ending “-cept” block cytokines and, accordingly, prevent cell cooperation; drugs with the ending “-ximab” contain animal mAbs and, by binding to tumor necrosis factor α, block it; with the ending “-mumab” - only human (humanized) MAbs with a similar mechanism of action.

MAT in the treatment of psoriasis is characterized by high efficiency. Due to the manifestation of anticytokine activity, they act specifically on the links of the pathological process, as a result, the quality of life of patients is noticeably improved, and a long period of remission of this disease is achieved [10].

The prescription of such drugs, despite their high clinical effectiveness, is associated with a number of contraindications and the appearance of undesirable reactions in the form of nausea, headache, and decreased blood pressure. Cases of the development of certain autoimmune diseases, as well as exacerbation of infectious processes against the background of their long-term use, have been described. Today, the prescription of MAT remains a therapy for the “select”, since the widespread use of these drugs is hampered by their significant exchange cost [11].

The high clinical effectiveness of drugs that can influence the immunological mechanisms of psoriasis development is not in doubt today, but the problem of developing new immunotropic drugs remains urgent, the use of which, along with high efficiency, will be characterized by a low level of adverse events and availability for widespread use in everyday medical practice .

The modern development of the Russian pharmaceutical industry within the framework of the development strategy of the pharmaceutical industry of the Russian Federation (RF) for the period until 2022 has made it possible to bring to the market a number of high-tech domestic pharmacological drugs characterized by a high profile of effectiveness and safety. It should be noted their low cost, which can significantly reduce the exchange rate of treatment compared to foreign drugs.

The result of many years of hard work was the first representative of a new generation of synthetic peptide immunosuppressants - Timodepressin

.
Timodepressin
was developed by a team of researchers at Pharma Bio LLC in collaboration with the Medical Radiological Research Center of the Russian Academy of Medical Sciences (Obninsk) and the Institute of Immunology of the Ministry of Health of the Russian Federation (Moscow).
The drug was approved by the Pharmaceutical Committee of the Ministry of Health of the Russian Federation for medical use in 2000 (registration certificate number: P No. 000022/01-2000; P No. 000022/02-2000; P No. 000022/03-2000; P No. 000022/04-2000) . Thydepressin
is a synthetic dipeptide consisting of D-amino acid residues of glutamic acid and tryptophan.

Timodepressin

(γ-D-glutamyl-D-tryptophan disodium salt) is an individual chemical compound of peptide nature, obtained by chemical synthesis as a result of structural and functional studies of biologically active low-molecular peptides. The drug is available in the form of a 0.1% solution for injection in 1 ml ampoules (5 ampoules per package), as well as in the form of a nasal spray in 5 ml (0.5 mg) bottles.

Consisting of unnatural D-amino acids connected by a γ-peptide bond, Thymodepressin

is a new class of synthetic peptide drugs that selectively block the proliferation of immune precursor cells.
The specific properties of the drug Timodepressin
make it possible to selectively suppress the functional activity of immunocompetent cells, inhibit the development of autoimmune processes without affecting the cells of other organs and tissues, while minimizing the risk of side effects.
Thydepressin
can be used both as monotherapy and in complex treatment of patients with various diseases. The drug is approved for the treatment and prevention of autoimmune diseases of various origins: autoimmune primary and secondary cytopenias, hypoplastic anemia, rheumatoid arthritis, psoriasis; as a cytoprotective therapy to protect and preserve stem cells, to prevent granulocytopenia, during cytostatic chemotherapeutic effects.

Timodepressin is administered

intramuscularly and intranasally. At the initial stage of treatment, the drug is prescribed systemically; The course of treatment and dosage regimens are selected individually depending on the dynamics of clinical manifestations. A single dose is 1 ml of a 0.1% solution, the maximum single dose is 2 ml of a 0.1% solution. The drug is administered once daily.

Timodepressin

used in adults and children from the age of two, used both in monotherapy and in complex treatment and prevention of psoriasis: the drug is administered intramuscularly at 1-2 ml of solution daily for 7-10 days, then a break for 2 days, then the cycle is repeated. Depending on the clinical situation, 3 to 5 cycles can be performed.

Intranasal Timodepressin

prescribed primarily as maintenance therapy and for the prevention of relapses, as well as in the treatment of children. The drug is administered 1-2 doses (0.5 mg) of nasal spray into each nasal passage daily for 7-10 days, the course of treatment can be continued after a 2-day break.

For patients with generalized psoriatic erythroderma Timodepressin

2 ml of solution is administered intramuscularly daily for 14 days, then intranasally with the simultaneous addition of GCS in medium doses.

Comparative analysis of the results within the departments supervised by the teaching staff of the Department of Dermatovenereology of the Pediatric Faculty of the State Budgetary Institution of Higher Professional Education of the Russian Research Medical University named after. N.I. Pirogov, in the period from 2000 to 2013 demonstrated high clinical effectiveness of the inclusion of the drug Timodepressin

in treatment regimens for patients with psoriasis.
Moreover, the severity of the therapeutic effect of the drug Timodepressin
was not determined by the characteristics of the clinical variant of psoriasis - favorable results after treatment were observed with approximately the same frequency in various forms of psoriasis, which led to a significant improvement in the quality of life of patients.
In some cases, in terms of the strength of the therapeutic response and the dynamics of regression of the psoriatic process, Timodepressin
was superior to routine methods of treating psoriasis.
The use of the drug Timodepressin
was not accompanied by the development of side effects inherent in known immunosuppressants; In addition, it is convenient to use both in hospital and outpatient practice.

Ointment for psoriasis based on tar

The most popular tar-based ointments are:

1. Super Psori cream
   Super psori cream. The drug has not a therapeutic, but a cosmetic effect. It contains birch tar, naftalan oil, grease and auxiliary substances. According to reviews from forums, the cream is effective as part of complex therapy for psoriasis. Read more about its composition, side effects and results in the publication: “Super psori cream for psoriasis.”
2. Cream Picladol
   Cream Picladol. Solid oil based product. In addition, it contains herbal extracts, birch tar, and oils. All these substances treat psoriasis. However, reviews about the cream are mostly negative:

Nest user review

Indications

Due to its richness in useful substances, birch tar is used for the treatment of many diseases:

• psoriasis, except for the exudative form (in this case, with caution);
• other diseases and skin lesions (eczema, scabies, seborrhea, mycoses, burns, bedsores, trophic ulcers, etc.);
• hemorrhoids, erosive proctitis;
• postpartum mastitis;
• bronchial asthma;
• infectious diseases (bronchitis, tuberculosis, otitis media, tonsillitis);
• diseases of the urinary system (urethritis, cystitis);
• helminthic infestations, pediculosis;
• prevention of oncology (for mastopathy, ovarian cyst, adenoma);
• For cosmetic purposes, tar is used to strengthen hair, rejuvenate skin, etc.

Tar from scalp psoriasis

Shampoo Psoril

Tar soap helps against psoriasis of the scalp, which disinfects and removes flaking. escortstars. There is a significant drawback: a pungent odor that is difficult to remove. Therefore, it is more pleasant to use ready-made shampoos for psoriasis on the head.

1. Psorilom shampoo contains birch tar and herbal extracts. Reviews about the product are mostly positive.
2. Friderm tar psoriasis shampoo contains purified coal tar. Reviews about it are mixed, and there are no studies in the public domain.
3. Algopix shampoo contains juniper tar, salicylic acid (main active ingredient), algae extracts. Reviews about the drug are positive.

Stages of acute opisthorchiasis

When it comes to acute opisthorchiasis, it is divided into 4 classes.

1. Typhoid-like course - there are symptoms of pancreatitis, jaundice and hepatitis, an enlarged liver, gastritis, eosinophils in the blood up to 90%.
2. Hepatocholangetic type - pancreatitis, aching abdominal pain, the liver is affected, the function of the pancreas is impaired.
3. Gastroenterological – the presence of enterocolitis, stomach ulcers, erosive gastritis, stool disorders are observed.
4. Damage to the respiratory tract - the presence of asthmatic-type bronchitis, pleurisy and pneumonia.

Tar for psoriasis: recipes

Before using a prescription, consult your doctor and carefully monitor your body’s reactions:

1. Tar inside: in the first week of treatment, 1 drop. In the second week of treatment, 2 drops. According to reviews, this recipe helps strengthen the body, does not get rid of plaques, but their growth stops.
2. Tar externally - Vishnevsky ointment. Take 3 parts birch tar, 3 parts xeroform, 94 parts castor oil, mix. Apply an even layer to psoriatic plaques.
3. Tar is used externally both in purified form and mixed with birch ash.

How is the disease diagnosed?

The first thing you need to do if you find signs of opisthorchiasis is not to self-medicate, but to seek the advice of a gastroenterologist. The doctor will conduct a visual examination, collect anamnesis and refer for tests and duodenal intubation. This is a method of examining a patient, which is carried out for diseases of the biliary tract and gallbladder to collect bile for laboratory testing.

Other types of diagnostics:

• general blood analysis;
• examination of internal organs using ultrasound;
• stool analysis for worm eggs;
• polymerase chain reaction (PCR).

After the diagnosis, the doctor examines the results of all tests and studies and gives the patient an accurate diagnosis. After an accurate diagnosis is made, the patient is prescribed treatment. It is carried out under strict supervision.

Tar for psoriasis: reviews

There are many positive reviews. But everyone notes a sharp, unpleasant smell of tar, which is difficult to remove:

Review from user Indeborga

Review from user Marla

Review from user Marjushka

User review Guest_Anton

conclusions

Tar for psoriasis is used both in pure form and as part of ointments, creams and shampoos.

Tar affects the skin from different sides:

• anti-inflammatory effect;
• bactericidal and antiseptic effect;
• relieves itching.

The most popular creams with tar: Super psori cream, Picladol cream.

The most popular shampoos with tar: Psoril, Algopix, Friederm tar. Tar soap is also used for scalp psoriasis.

Tar against psoriasis is effective and helps many, but there is a significant feature: a strong pungent odor. The variety of remedies for psoriasis allows you to choose the one that suits both price and effect.

1. To exfoliate dry scales, choose non-hormonal ointments or shampoos with natural ingredients.
2. To remove plaques, shine them with ultraviolet 311 nm.
3. Follow a diet for psoriasis.
4. Think optimistically, set yourself up for recovery.

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