Inflammation in the mouth: symptoms, treatment and prevention

It's all the virus's fault!

The term "stomatitis" is derived from the merger of two Greek words: stoma (mouth) and itis (inflammation). There are a great variety of different types of disease - serous, aphthous, allergic, etc. The most dangerous is herpetic, or cold sore, stomatitis caused by a virus. Its main manifestations are painful ulcers covering the oral mucosa. The trigger mechanism of the disease is the activation of herpes simplex virus types 1 and 2. First of all, the disease threatens those who have a weakened immune system and, as a result, the body simply does not have the strength to give a worthy rebuff to viruses.

Forms of the disease

Lightweight

It is considered the most beneficial for the body. In this form, people with high immunity suffer from herpes stomatitis. It flows without temperature. It is distinguished by single rashes that do not cause discomfort and disappear on their own without consequences.

Average

General disorders are added: weakness, drowsiness, fatigue, loss of appetite. Rashes appear in several places at the same time. The temperature rises to 37-37.6°C.

Heavy

This form of stomatitis indicates extremely low immunity. The rashes are multiple and painful. Severe headache, chills, and vomiting appear. The temperature exceeds 38oC.

If the disease is mild, the patient may not notice any external signs!

How to distinguish herpes from stomatitis?

Many patients try to find an answer on the Internet to the question: “Do I have stomatitis or herpes? How to recognize? Herpes stomatitis can be easily distinguished from ordinary stomatitis by 3 key signs.

1. With herpes infection, the rash is localized in the gum area. Whereas with stomatitis - on the soft tissues of the oral cavity (tongue, cheeks).
2. A herpes rash first appears as blisters, which then ulcerate, while stomatitis begins with the appearance of ulcers.
3. Herpetic stomatitis is characterized by a stable appearance of the rash in the same places, and with ordinary stomatitis its location often changes.

Herpetic or aphthous?

It will be somewhat more difficult to distinguish between herpetic and aphthous stomatitis. The latter got its name from the Greek term “aftha”, which means “ulcer”.

If with herpetic stomatitis there are many ulcers, but they are small, then with aphthous stomatitis there are few of them, and the size can reach 7–8 mm.

The second important distinguishing feature is the absence of swelling of the gums with aphthous stomatitis.

If you are looking for differences between herpetic and aphthous stomatitis, then the third thing you should pay attention to is the localization of the rash. Aphthous is characterized by the appearance of ulcers in the oral cavity, while herpes infection can spread to the border of the lips.

Symptoms of inflammatory diseases

Inflammation in the oral cavity is manifested by both general and local symptoms [1]. Even before the onset of local manifestations, general malaise, pain, irritation, rashes in the mouth, increased body temperature, and decreased appetite are noted [1]. In addition, inflammation in the mouth itself can act as a symptom of another disease or general pathology [1].

Symptoms of certain inflammatory diseases

Stomatitis is a wide group of diseases that can be caused by individual pathogens, for example, fungi (candidal stomatitis) or the herpes simplex virus (herpes stomatitis), and systemic diseases, for example, chronic diseases of the gastrointestinal tract (aphthous stomatitis) [2] .

Most often, stomatitis appears as rashes (ulcers, blisters or other forms) on the oral mucosa. The nature of the rash is a striking distinctive feature that plays an important role in diagnosis. For example, with aphthous stomatitis, the ulcers never appear on the outer surface of the lips, as is the case with lesions caused by the herpes simplex virus [2].

Herpetic stomatitis, as a rule, accompanies a general infection of the body and is characterized by rashes on the inner surface of the cheeks, tongue, palate, and lips [2].

With insufficient oral care, bacterial microflora may develop and cause deeper lesions of the mucous membrane.
If the necessary treatment of acute herpetic stomatitis is not carried out, a recurrent form occurs, which is accompanied by regular rashes on the oral mucosa of vesicles and aphthae "Microbiology, virology and immunology of the oral cavity", ed. Doctor of Medicine V. N. Tsareva.

Catarrhal stomatitis occurs quite often and develops due to the lack or poor hygiene and the presence of chronic foci of infection in the oral cavity. Symptoms of this type of stomatitis are swelling of the mucous membrane, the appearance of plaque on it, first white, then brown, and bad breath [1].

Candidiasis (candidal stomatitis, thrush) is caused by fungi of the genus Candida, which are normally always present in the mouth in small quantities [2]. Factors contributing to the sharp growth of fungi are long-term use of antibiotics and some other drugs, hypovitaminosis, endocrine and other disorders.

A striking symptom of candidiasis is the appearance of a white or yellowish-white coating on the tongue and the mucous membrane of the cheeks due to the development of inflammation in the mouth. The plaque is easily removed, revealing reddened, inflamed and eroded areas of the oral mucosa underneath.

Leukoplakia refers to chronic inflammatory diseases. It develops in response to constant irritation of the oral mucosa, for example, from a part of a denture, a sharp edge or chipped tooth, hot drinks or food, alcoholic beverages, or smoking [1]. Leukoplakia manifests itself in the form of whitish thickenings, usually in the cheek area along the line of closure of the teeth, in the corners of the mouth, on the back and on the lateral surfaces of the tongue.

How to distinguish herpes sore throat from stomatitis?

Despite the fact that these medical terms have the same grammatical root, herpetic sore throat and herpetic stomatitis are two different diseases. Unlike stomatitis, herpes sore throat occurs not due to the penetration of the herpes virus, but as a result of an adenovirus infection (in particular, the Coxsackie A virus). Children are more likely to suffer from this disease than adults. The rashes are localized, for the most part, on the soft palate and tonsils. Typical symptoms of stomatitis include pain in the abdomen and abnormal bowel movements.

Attention!

The disease begins acutely, with a jump in temperature to 40 degrees, and is severe, so differential diagnosis should only be carried out by a doctor.

Bacterial or viral?

In addition to viral origin, the disease can be caused by bacteria: streptococci and staphylococci are normally present in the microflora of the oral cavity and begin to multiply uncontrollably during the inflammatory process. The latter may be caused by caries or periodontitis (read more about the disease in the article).

How to distinguish viral stomatitis from bacterial one? It is extremely difficult to do this at home, so it is better to consult a doctor. The main differential feature is the localization of the rash. With viral herpetic stomatitis, vesicles with transparent contents first appear on the tongue (its tip, along the side surfaces and under it), and then can even spread to the pharynx and tonsils.

For bacterial stomatitis, the location of the rash on the gums and those areas where the skin borders the mucous membrane (for example, on the red border of the lips) is more common. Also, with a disease caused by streptococci, “jams” are often observed - pustules on the corners of the mouth, which quickly begin to bleed, become covered with a crust, crack and cause constant discomfort while eating and talking.

Types of diagnostics

An experienced doctor can identify herpetic stomatitis in adults during an initial examination, relying on only two methods.

• Clinical picture.
  Based on the totality of the patient’s specific complaints and distinctive external signs, the dentist will not only assess the severity of the disease, but also differentiate it from ordinary stomatitis, candidiasis, etc.
• Immunofluorescence.
  Express microscopy method, the most accurate for diagnosing acute herpetic stomatitis.

Causes of candidiasis

Thrush in the mouth of an adult is a lesion of the mucous membrane, which may indicate serious health problems. For the fungus to multiply, special conditions are required. Most often, the disease occurs in patients who neglect oral hygiene. The presence of caries and inflammatory gum diseases increases the chances of developing fungal inflammation. This is explained by the fact that a large number of pathogenic microorganisms depletes the defense mechanisms.

The second group of reasons is weakened immunity due to a number of diseases and conditions:

• HIV, diabetes mellitus;
• oncological diseases;
• dystrophy, deficiency of vitamins and minerals;
• previous operations, severe infections, etc.

There are also specific reasons for the development of thrush. It can appear after prolonged and powerful antibacterial therapy. The use of antibiotics leads to the destruction of beneficial flora and imbalance. This causes active reproduction of Candida.

Oral candidiasis also develops while taking inhaled corticosteroids. Usually the lesion has the appearance of erythema and appears in areas where the medicine came into contact with the mucous membrane: on the palate, tongue.

Dietary features affect the likelihood of developing candidiasis. Thus, the predominance of carbohydrates predisposes to fungal activity. The growth of Candida and its attachment to the mucosa are enhanced in the presence of sugars.

Bad habits increase the chances of developing leukoplakia, lichen planus and other diseases. This is especially true when it comes to smoking. Candidiasis often develops in patients with tongue piercings.

The presence of removable dentures is also a risk factor if the patient does not comply with hygiene rules. In the absence of high-quality cleansing, the prosthesis becomes covered with a biofilm, which contains a lot of fungi. Disinfection is the main measure of disease prevention and part of complex treatment for progressive oral candidiasis. If the patient does not remove the structure at night, this also increases the likelihood of developing the disease. The mucous membrane remains without oxygen for a long time and is not washed by saliva - these conditions are suitable for the development of fungi and anaerobic microorganisms. The prosthesis can injure the mucous membranes if it does not fit. Microtraumas weaken local defenses and contribute to the onset of fungal infection. Injuries can also be associated with sharp chips of teeth and fillings, chemical and thermal burns.

Dry mouth due to decreased salivation, changes in saliva viscosity and its composition is one of the causes of candidiasis. This can be caused by other diseases, so it is important to find out the causes of dryness in order to effectively combat the consequences.

Candidiasis in the mouth of a child is more common. The immaturity of the immune system and the colonization of the oral cavity by Candida from the mother’s vaginal canal during natural childbirth lead to the development of the disease in early infancy. However, older children can also suffer from the disease, which is associated with weakening immune forces.

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Causes of herpes stomatitis

There are two types of herpetic stomatitis: acute and chronic. Acute herpetic stomatitis, according to Dr. Komarovsky, occurs only in children under 3 years of age, when for the first time the child’s body, already deprived of antibodies to the herpes virus received from the mother, is first exposed to a viral attack from the outside. Moreover, the source of infection, as a rule, is the parents themselves - carriers of the virus, who kiss the baby or lick his pacifier or feeding spoon.

Recurrent or chronic stomatitis is already the lot of adults. The disease is recurrent in nature as soon as the body’s immune forces are weakened. In this case, primary infection can occur either through airborne droplets (sneezing), or through household contact (for example, through the use of the same dishes with a virus carrier) or hematogenous (through blood during injections, etc.). The incubation period of the disease can last up to two weeks depending on the state of the immune system.

Attention!

The pathogenesis of the disease in dentistry is still unknown. But if the body is weakened, any injury to the palate or gums can provoke activation of the herpes virus types 1 and 2!

Types of inflammatory diseases of the oral cavity

These diseases are classified depending on what causes the inflammation, as well as on the location of its source in the mouth.

Thus, general lesions of the mucous membrane are called stomatitis [1]. If the mucous membrane of only the tongue, lip, palate, gums or alveolar process becomes inflamed, they speak of glossitis , cheilitis, palatinitis, gingivitis or periostitis, respectively.

Depending on the reasons that caused the inflammatory process, these diseases are divided into:

• infectious;
• traumatic;
• symptomatic;
• specific.

If left untreated, inflammation can occur with complications and have negative consequences both for the teeth, gums, mouth and pharynx, and for the general health of a person.

Treatment of herpetic stomatitis

How to treat herpes stomatitis? Unfortunately, the herpes virus, once entered into a person’s blood, remains in a “dormant” state for the rest of his life. But treatment of viral stomatitis is possible provided that you do not delay visiting the dentist when the first signs of the disease are detected. During the period of therapy, in order to avoid infecting loved ones, you should eat and drink from separate containers and avoid kissing. The patient is recommended a diet that excludes spicy, smoked, sour and salty foods, which can irritate the damaged oral mucosa, and an increased drinking regimen (up to 2.5 liters per day), aimed at combating the manifestations of general intoxication of the body.

Diagnostic methods

The treatment is carried out by a dentist-therapist. Diagnosis begins with an examination and a detailed survey: the doctor will find out what medications you have taken recently, and whether there are any chronic or infectious diseases. A cytological examination of plaque taken from the mucosa is mandatory. This is important because a buildup of non-fungal flora can easily be confused with a fungal infection.

The scraping is performed in the morning, on an empty stomach; there is no need to brush your teeth before the procedure. The day before, it is important to avoid eating foods rich in carbohydrates so as not to provoke the growth of pathogenic flora. Research allows not only to accurately determine the causative agent and type of Candida fungus, but also to find out the sensitivity of fungi to the main antifungal drugs. Based on the test results, the doctor will determine the fungus in the oral cavity and prescribe medication.

Drug therapy

Rinse

To stop the spread of infection throughout the oral cavity, as well as to prevent the occurrence of sore throat, anti-inflammatory drugs such as Stomatidine and Miramistin are prescribed. The greatest effect is achieved by repeating the rinsing procedure every 3 hours, strictly adhering to the instructions for medicinal solutions.

Antiviral drugs

To suppress the reproduction of the herpes virus, the patient is advised to take “Immudon” and “Acyclovir” orally according to the scheme, and for external use - “Viferon” ointment or “Silicea” gel.

Vitamin therapy

Tablet vitamin complexes such as “Complivit” help improve immunity.

Attention!

Before use, consultation with a specialist is recommended!

Treatment at home with folk remedies

On the Internet you can often come across the question: “How to treat herpetic stomatitis with folk remedies?” Let’s make a reservation right away: when treating this disease, you cannot rely solely on traditional medicine methods. Therapy must be comprehensive, and only a doctor can choose it correctly.

An effective folk remedy for rinsing the mouth is propolis tincture diluted with boiled water 1:3. In case of pronounced “jams” in the corners of the mouth and painful ulcers inside, applications with natural sea buckthorn oil have an analgesic and wound-healing effect.

Features of treatment

The basis of treatment is systemic and local antifungal drugs. Today they are widely represented on the pharmaceutical market, but it is important to know that every year the level of resistance of Candida fungi to basic drugs increases. For example, resistance to drugs such as Fluconazole is almost complete. Previously, this remedy was used in almost all cases of the disease, but today doctors are forced to reconsider standard treatment regimens.

Treatment of oral thrush in adults is selected individually. The choice of systemic antifungal agent is based on the type of pathogen, the patient’s condition and the individual characteristics of his health. There are drugs to which the infection has minimal resistance. The doctor may prescribe drugs based on nystatin, imidazole derivatives, etc.

Additionally, local remedies must be used:

• solutions for rinsing the mouth;
• gels and suspensions for application to affected areas;
• local tablets and lozenges;
• Irrigation solutions and aerosols;
• ointments for placing in the oral cavity on a cotton-gauze swab, etc.

A specialist may prescribe pharmaceutical antiseptics or weak saline solutions for rinsing. Typically, solutions based on iodine, chlorhexidine, potassium permanganate, gentian violet, sodium tetraborate in glycerin are used. Your doctor may recommend placing some tablets in your cheek.

Prevention measures

1. Strengthening the immune system.
   Avoid excessive exercise and stress. Take a multivitamin in the fall and spring. Regular exercise and hardening increase the vitality of the body.
2. Healthy lifestyle.
   Get rid of bad habits: scientists have proven that excessive smoking and alcoholic beverages can become a catalyst for the activation of the herpes virus in the body.
3. Timely treatment of chronic diseases.
   Do not forget that simple stomatitis, if you do not seek medical help in a timely manner, can develop into herpetic stomatitis. Chronic caries and acute respiratory viral diseases suffered “on the legs” also seriously undermine the body’s immune defense.
4. Maintain personal hygiene.
   According to statistics, it is poor oral hygiene that most often opens the way for herpes infection.
5. Avoid oral trauma.
   Even a minor microcrack from a prick with a fish bone or careless use of a toothpick can become an “entry gate” for the herpes virus.

Attention!

With reduced immunity, herpes stomatitis becomes chronic and relapsing: the disease can recur 2-6 months after recovery.

Causes of oral herpes infection

Herpes that affects the oral cavity develops when infected with the herpes simplex virus type 1, which not only provokes the appearance of a blistering rash, but can also cause complications in 10% of cases. The second type of herpes virus (genital) also causes a rash in the mouth, but does not cause serious disruption to the body and differs in its mode of transmission (through sexual contact).

Most often, primary infection with a herpes virus occurs in childhood, after which it is introduced into the genome and remains in an inactive form for life.

The main routes of infection with a viral agent are close conversation, skin-to-skin contact, kissing, and the use of shared hygiene products or utensils. However, the entry of viral particles into the body does not guarantee that the disease will develop, since the immune system can suppress the action of the pathogen. In this case, situations that worsen the overall health of the body, on the contrary, provoke a clear manifestation of infection:

• surgical interventions;
• emotional and physical stress;
• lack of sleep, overwork;
• colds;
• chronic pathologies;
• long-term use of antibiotics;
• periods of menstruation, pregnancy or lactation;
• vitamin deficiencies;
• AIDS;
• abuse of nicotine or alcohol;
• the appearance of microtraumas from excessive exposure to the sun or frost.