Read online “Psoriasis. Ancient and modern methods of treatment"

Psoriasis: causes of appearance

It is currently unknown exactly how psoriasis develops In most cases, it is noted that the manifestation of psoriasis is due to a genetic predisposition (there are family members suffering from psoriasis ). In other people, the cause of psoriasis may be prolonged stress, a cold (most often a previous streptococcal infection is noted) or taking medications (for example, beta blockers, non-steroidal anti-inflammatory drugs, some antibiotics, and other drugs can trigger the onset of the disease).

The diseases that are most often detected in people with psoriasis and may play a role in its development include excess weight, various diseases of the endocrine and cardiovascular systems. Excessive alcohol consumption and smoking also negatively affect the course of the disease.

New possibilities for complex therapy of psoriasis

00:00

Oksana Mikhailovna Drapkina , executive director of the Internet Session, secretary of the interdepartmental council on therapy of the Russian Academy of Medical Sciences:

— Let’s move on to a new, very exciting section – dermatology. This is actually our first time in an online session. This is already the 27th Internet Session. Many dermatologists are now looking at the screens with interest, because the lecture will be given by Professor Yuri Nikolaevich Perlamutrov. It is called “New opportunities for complex therapy of psoriasis.”

Perlamutrov Yuri Nikolaevich , Doctor of Medical Sciences, Professor:

— Good afternoon, dear colleagues.

I am glad to have the opportunity to meet with such an impressive and professional audience, which is already immersed in various problems of medical science. But in conclusion, I think you will be interested in learning something new in terms of the treatment of such a common pathology in our specialty as psoriasis.

The current relevance of the disease is a change in the structure of dermatosis: an increase in disabling forms that are resistant to therapy, and the emergence of severe forms of psoriasis in people of young working age.

Very interesting statistics. Please note that 2-3% of the total population of planet Earth suffer from psoriasis. This is 120 - 180 million people. It is interesting that it is in the countries of Denmark (Scandinavian countries) that psoriasis is more common than in Kuwait. This can be explained by one thing - where the climate is more continental, sharply continental, low temperatures prevail, the incidence of psoriasis increases.

Epidemiology. Psoriasis affects men and women with equal frequency. Depending on the age at which this disease began, there are two types of the disease. The first type is the age from 16 to 25 years (the onset of the disease at this age). Patients who follow hereditary factors. It is very important. The rashes are common. In a very large percentage there is joint damage.

The second type, as we sometimes say, is the benign type. This is, of course, not a medical term. In this case it is not entirely correct. But it characterizes the fact that these patients have a favorable course of the disease and less resistance to therapy.

Psoriasis is a pressing social problem. Each dermatosis is accompanied by cosmetic defects. Such a common dermatosis as psoriasis naturally produces a larger volume of these defects. The psychological sphere of patients of this nosology suffers greatly.

The chronic course of psoriasis and resistance to common treatment methods lead to enormous financial costs for government and insurance medical organizations.

03:23

Despite the fact that this disease has already been known for over 2000 years, unfortunately, there is no effective treatment method that would once and for all rid the population of such a serious pathology (as I already said, entailing cosmetic defects and affecting the psychological status of our patients). , No.

I continue with the social aspects. Certain studies have been carried out. Please note that 63% of respondents do not want to enter into financial transactions with people who have psoriasis. People have a particularly negative perception and negative attitude when they communicate towards those patients with psoriasis who have lesions on the scalp.

In this regard, problems arise in people's lives. If you think that this is, first of all, a swimming pool and a sports club - no. In first place are places where people communicate. These are restaurants, clothing stores, only then come massage parlors, beauty club services, and so on.

The consequence of all this is a psychopathological disorder that occurs in our patients. 53% are in a mixed state, when the same patient has several disorders: neurotic, affective, and cognitive. The saddest thing is personality and desire disorders.

Thus, when we talk about the quality of life of patients with psoriasis, with that colossal sample (1150 patients who conducted the study), 35% of respondents have a pronounced decrease in quality of life (that is, more than a third of our patients). You understand how important this is as a social factor.

Psoriasis. On the one hand, as we have already talked to you, hereditary predisposition is a key etiological factor in the development of psoriasis. Triggers (what were previously called risk factors) are immune, neurogenic, endocrine, infectious, toxic and metabolic changes.

05:51

Pathogenetic aspects of psoriasis. Today, there are several main points, both in foreign and domestic dermatology, that determine the pathogenesis of this disease:

1. Pathological activity of T-lymphocytes.

2. Impaired functioning of the immune system (overproduction of interleukins 1? 2, 6, 7, 8, interferon factor gamma and tumor necrosis factor?).

3. Impaired microcirculation (increased levels of VEGF or vascular endothelial growth factor and decreased sVEGF, that is, vascular endothelial growth factor receptors).

4. Local hypoxia.

5. Impaired differentiation of keratinocytes.

6. Hyperproliferation of epidermal cells.

Thus, any doctor, even far from our specialty, understands perfectly well that the main effects with the help of medications should be aimed, if possible, at all these factors, or at least at most of them.

A very important factor is the comorbid conditions of psoriasis. The cellular metabolism of kertinocytes and their pathological proliferation (I draw attention to this point - proliferation) are the result of structural and organ disorders. First of all, metabolic abnormalities; diseases of the cardiovascular system; diseases of the gastrointestinal tract, hepato-biliary system and mental disorders.

Psoriasis and metabolic syndrome. I have no doubt that the distinguished lecturers who have addressed me today have mentioned this term. I show once again that this is a very important point. Of course, there are different specialties in medicine. There is gastroenterology, cardiology, therapy, dermatology. But there is one patient with all the problems. A deviation in one system entails a change in the functioning of another system.

Especially when we talk about skin. The skin, which on the one hand is the most observable organ. On the other hand, it is an organ that instantly reacts to some deviations in the functions of the human body.

Thus, speaking about psoriasis, such a common pathology, one of the dominant pathologies in our specialty, naturally, we must dwell on the question “Psoriasis and metabolic syndrome.”

08:21

Back in 1995, scientists noted a direct correlation between obesity and the severity of psoriasis. It has been established that in patients with psoriasis, the average body mass index is higher than in the general population.

(Slide show).

These graphs show a very large sample, control over 1000 people, psoriasis about 600 people. There are changes in type 2 diabetes (specific gravity in psoriasis) and specific gravity of hyperlipidemia also in dermatological pathology.

Coronary heart disease, arterial hypertension. Nowadays there are a lot of works appearing. Dissertation works. In particular, a dissertation was defended at our department on a very important point - hypertension in psoriasis. Here we refer to foreign authors because they have a larger number of observed patients. But the same studies are being conducted in Russia.

Psoriasis and pathology of the gastrointestinal tract and hepatobiliary system. In patients with psoriasis, a combined pathology is determined in 75% of cases. Fatty liver, and biliary dyskinesia, chronic hepatitis, chronic pancreatitis, cholecystitis, gastritis, duodenal ulcer.

Thus, we must also emphasize that cholecystobiliary insufficiency occurs in the majority of patients with psoriatic arthritis. A very important point, I would like to draw your attention to it, is that these are studies conducted by Russian authors.

10:23

Psoriasis-psychiatric disorders. We talked about metabolic syndrome. We talked about the pathology of the gastrointestinal tract. Now we touch on psoriasis and mental disorders.

Please note, 64% - dysthymia, mild recurrent depressive disorder - 23%. Recurrent depressive disorder of moderate severity in 13%. More than 40% of patients with psoriasis have disorders in the sexual sphere. Moreover, it was in these patients that joint damage was more often recorded. The same psoriatic arthritis that leads to rapid disability of our patients.

Psoriatic arthritis. Currently, psoriatic arthritis is considered as an independent inflammatory disease of the joints associated with skin psoriasis, and seronegative for rheumatoid factor. It is registered in 10–20% of patients with psoriasis, that is, in almost every fifth patient with psoriasis.

If you remember the figure that I gave at the very beginning of my speech (120 - 180 million people suffer from psoriasis in the world), then you will agree that 20% of 180 million is a significant figure. 20% have psoriatic arthritis. A pronounced systemic manifestation is often observed, namely, high and prolonged fever, lymphadenopathy, arthritis, carditis, hepatopathy, diffuse glomerulonephritis, and renal amyloidosis.

A very interesting point that I draw the attention of my colleagues is that joint damage is more common in patients with psoriatic disorders localized to the scalp and damage to the nail plates. On the one hand, it would seem that there are only nails and hair (this can also be the case), but the lesion may be generally limited only to the scalp. At the same time, the patient faces such a severe disabling pathology as joint damage.

Based on all the information base that I presented to you (the many triggers that lead to the formation of this pathology, the pathogenesis of this disease, the disorders that we encounter, which are present in a patient with psoriasis), naturally, it was interesting to find some new therapeutic approaches to treating such a complex multifactorial pathology.

We set ourselves the task of determining the effectiveness and feasibility of including the drug Heptral (Ademethionine) in the complex therapy of patients with psoriatic arthritis.

13:15

The study material included 45 patients, of whom there were 9 women and 36 men. All these patients were in the hospital-progressive stage. There was not a single patient in a regressing stage of the disease. The duration of the disease ranges from several months to 23 years. Most often from 2 to 15 years. The anamnesis was quite significant.

I would like to draw your attention to one more very important point. I deliberately left it at the end of my acquaintance with this image. This is what patients with psoriatic arthritis with laboratory signs of liver damage and depressive disorders. It was precisely these patients that interested us.

Localization of articular syndrome. Classic: inflammation of the interphalangeal joints of the feet and hands. Naturally, there were fewer large joints in percentage. Sedentary joints of the iliosacral joint - only more than 4%. X-ray examination revealed both early signs of inflammatory phenomena and late ones, characteristic of psoriatic arthritis.

All patients (45 people) were randomly divided into 2 groups. One received traditional therapy (that is, nonspecific anti-inflammatory drugs and other known drugs). The second group (30 people) - Heptral was added to this standard therapy, 2 tablets 2 times a day for three weeks.

What is Heptral? This is a biologically active compound, similar (very important point) to intracellular ademetionine. On the one hand, this is a drug that is produced under pharmaceutical production conditions. On the other hand, it is similar to a compound found in our body.

The equivalence of Heptral to endogenous ademetionine determines the high level of effectiveness of the drug and the rapid achievement of a therapeutic effect due to its complete inclusion in biochemical reactions. An extremely important point is that Heptral, on the one hand, is a hepatoprotector with antidepressant, detoxifying, regenerating and neuroprotective effects. This is precisely what attracted our attention, based on the information that I introduced you to in the debut of my speech.

16:00

We took materials from PASI, naturally. We took a visual analogue scale, the level of depression and an assessment of the results of a biochemical blood test.

Research results. PASI before and after treatment. I think the numbers speak for themselves. In the second group (the same one where 30 patients received Heptral), the effect was 2.5 times better than in the standard therapy group.

The visual analogue scale showed us that after treatment we got a fantastic zero both at rest and in motion. These achievements are very significant. Naturally, in the group (the first) where there was simply standard therapy without the use of the drug Heptral.

Research on the Hamilton scale. Indicators of depression (group 2). After two weeks we got, perhaps, not so significant differences. A month later, it almost doubled (maybe, I dare say in a simplified way - less, naturally, than doubled, but the numbers vary significantly).

Biochemical studies gave us very good numbers in the second group (where Heptral was used). A dynamic that really inspired us. Whenever we start treating our patients...

I will not list other drugs for you. If we use biological agents, cytostatics, steroids and other very powerful drugs, then the biochemical sphere suffers along with the clinical effect. In this case, we had a clinical effect, but had very good blood biochemistry indicators.

Thus, all the research we conducted allowed us to draw a number of conclusions. Firstly, that this drug in the complex therapy of psoriatic arthritis helped reduce the PASI index by more than 80%. It was accompanied by regression of pain syndrome, reduction of signs of depressive disorders and normalization of metabolic processes.

Three very important factors that we discussed, contributing to the development of dermatological pathology with joint damage, were stopped by this method of therapy. Naturally, the use of this drug increases the effectiveness of treatment of patients, which determines the need for its use in this category of patients.

What I would like to say in conclusion. Naturally, our work in the therapeutic approach to such a pathology as psoriatic arthritis inspired us. We got a positive effect. It's inspiring. But today, unfortunately, we do not have a radical method of treating psoriasis. Without a doubt, there will be many more studies and publications. This studio will feature new messages about successful therapy for psoriasis.

Thank you for attention.

How psoriasis manifests itself:

The first symptoms of psoriasis usually appear before the age of 20, but there is a second peak in incidence - 50-60 years. The characteristic signs of psoriasis are presented in the photo and are described as clearly demarcated and slightly raised rashes (papules or plaques) of a pinkish-red color, covered with whitish scales. Most often, the elements are located symmetrically on the skin and affect the outer surface of the elbow or knee joints, the skin of the torso or the scalp.

Psoriasis course and at different stages the rash manifests itself in its own way. So, in the initial or progressive stage, multiple small pink or red rashes appear, covered with scales. At this stage, you need to treat your skin with care, because... In places of mechanical damage, fresh psoriatic rashes may appear. In the next stage - stationary, the existing rashes become larger and can merge into plaques. Peeling on the surface of the rash becomes more pronounced. In the third stage - regressive, peeling is greatly reduced, and the rashes begin to disappear spontaneously. Ultimately, more intensely colored spots remain at the site of the rash, but over time they disappear without a trace. How psoriasis and looks at different stages of the disease can be seen in the photographs presented.

Photo 1. Psoriasis. Initial stage.

Photo 2. Psoriasis. Initial stage.

Photo 3. Psoriasis. Initial stage.

Photo 4. Psoriasis. Initial stage.

La-Cri cosmetics for hand psoriasis

Long-term remission can only be achieved if the main preventive measures are followed. People prone to psoriasis need to regularly moisturize their skin using cream or ointment. You should also prevent skin contact with cleaning products (wear gloves, etc.) and, of course, follow a diet.

Psoriasis leads to excessive dryness of the skin, so one of the main components of treatment should be hydration. But ordinary moisturizing creams are not suitable for psoriasis, as they may contain fragrances and other substances that can cause irritation. La-Cri cream for dry skin saturates the skin with fats, moisturizes it, reduces moisture loss and restores hydrolipid balance. The product can also be used to protect the skin from cold and windy weather.

This cream is based on natural ingredients and does not contain parabens, fragrances or chemical components. It is completely neutral and safe, so it is suitable even for pregnant women and children.

The La Cree line of neutral cosmetics also includes other products for the care of sensitive skin that can be used by people with skin diseases, including psoriasis. This cosmetics will help you maintain the beauty of your hands and prolong periods of remission as much as possible.

Psoriasis. Exacerbation.

In addition to skin rashes, psoriasis can affect the scalp and nail beds. Symptoms of scalp psoriasis Often the rashes are located along the hairline.

Symptoms characteristic of psoriasis of the nail plates include pinpoint impressions that give the nail a thimble-like appearance; the appearance of yellowish-orange spots under the nail plate, accompanied by separation (peeling) of the nail from the nail bed and thickening of the nail plate and a change in the contour of the nail.

Symptoms of psoriasis are shown in the photo below.

Photo 1. Symptoms of psoriasis.

Photo 2. Symptoms of psoriasis.

Photo 3. Symptoms of psoriasis.

Photo 4. Symptoms of psoriasis.

Symptoms of psoriasis on the hands

Symptoms of psoriasis on the hands are accompanied by constant itching, which can be treated with proper treatment. If the patient scratches the rash, numerous wounds can be seen on his skin. Typically, such wounds heal much faster in children than in adults.

The main symptoms of psoriasis on the hands:

• the skin turns red and dries out;

• the affected area swells and thickens;
• psoriatic lesions crack;

• single spots merge and may appear in new places;

• peeling usually worsens in winter;
• if the disease is not treated, the fingers swell and become covered with thickened, painful plaques;

• nails quickly become damaged, change color (become yellowish or brown), crack and become stained.

Diagnosis of psoriasis

The diagnosis of psoriasis is made by a dermatologist after an in-person examination of the entire skin. There are a number of skin diseases from which psoriasis rashes should first be distinguished. These include eczema, lichen planus, contact dermatitis, toxicoderma and other diseases.

The first symptoms of psoriasis may be nonspecific, modified by self-administration of medications at home, and require long-term observation of the rash to make a correct diagnosis or a skin biopsy.

Treatment of psoriasis on hands and nails

Treatment of psoriasis on the hands and its symptoms is considered difficult. Even during periods of remission, spots may remain noticeable, although they decrease in size. To achieve the best effect, doctors use an integrated approach. In this case, numerous parameters are taken into account: the type of disease, the patient’s age, other pathologies, etc. A biopsy is used to confirm the diagnosis.

The following methods and means are used in the treatment of psoriasis:

• local keratolytic preparations (ointment, cream) for exfoliation and rejection of scales;
• ointments that help soften and heal the skin, and sometimes reduce itching and inflammation;
• antihistamines that fight swelling and itching;
• medications to support the liver and restore the functioning of the gastrointestinal tract;
• systemic therapy (biological drugs, systemic anti-inflammatory drugs);
• analgesics (if your nails or joints hurt);
• Psychological and pedagogical support also plays an important role in the treatment of psoriasis, especially in children.

Also, in the absence of contraindications, the patient may be prescribed physical therapy and phototherapy (UVB therapy and PUVA therapy).

Also, in the absence of contraindications, the patient may be prescribed physical therapy. A beneficial effect was shown by hand massage using healing creams and ointments that increase blood circulation. However, before using such products, it is better to consult with your doctor. He will eliminate the possibility of side effects and check for possible contraindications.

It's time to act!

It will be possible to talk about a complete victory over psoriasis only when the capabilities of genetic engineering are at such a level that they learn to “correct” genes - after all, as we remember, the disease is most often transmitted hereditarily. But today you can take control of psoriasis and achieve stable remission - live without skin and joint manifestations. To do this, you need to consult a doctor at the first suspicion of the presence of the disease and strictly follow all the recommendations of a specialist. In addition, a patient with psoriasis must:

• exclude alcoholic beverages, spices, smoked, pickled, and canned foods from the diet;
• avoid even minimal skin injuries: avoid visiting a bathhouse, sauna, or using a hard washcloth;
• use specially selected skin care products, including soap, shower gel, shampoo;
• try to avoid prolonged exposure to the sun and exposure to direct sunlight.

And one last thing. Remember: often therapy for psoriasis and psoriatic arthritis is ineffective, not because one or another drug “does not work.” The “human factor” comes to the fore: treatment of any chronic diseases requires a long time and involvement of the patient himself in the process. But many people want a quick effect, stop following the recommendations of their doctor, and end up with an exacerbation of the disease instead of the long-awaited relief. Today, fundamentally new opportunities have appeared in the arsenal of doctors and patients - anyone who is faced with the problem of ineffective treatment or side effects of drugs should know about this. Perhaps the fight for clear skin and a high quality of life begins now!

Bibliography:

1. https://allergiyanet.ru/zabolevaniya/psoriaz/izvestnye-lyudi-s-psoriazom.html
2. https://apps.who.int/iris/bitstream/10665/204417/1/9789241565189_eng.pdf
3. https://apps.who.int/iris/bitstream/handle/10665/204417/9789241565189_eng.pdf;jsessionid=6DEE32164BD2F36DD74AD95657BAF3A4?sequence=1
4. https://apps.who.int/iris/bitstream/handle/10665/204417/9789241565189_eng.pdf?sequence=1
5. Sun L. et al. Applied Informatics 2014, 1:3.
6. Smith CH et al. BMJ. 2006. Aug 19; 333(7564): 380–384.
7. Advances in psoriasis: A multisystemic guide / ed. by Weinberg JM, Lebwohl M. London: Springer-Verlag, 2014. 340 p.
8. Varni JW et al. Eur J Pediatr. 2012; 171:485–92, 2.
9. Hrehorow E. et al. Acta Derm Venereol. 2012; 92:67–72, 3.
10. Azevedo VF et al. An Bras Dermatol. 2013 Mar-Apr; 88(2): 233–236.
11. Gaskoin G. On the psoriasis or lepra. J. & A. Churchill, 1875. 259 p.
12. Kim WB et al. Can Fam Physician. 2022 Apr; 63(4): 278–285.
13. Altomare GF et al. J Rheumatol Suppl. 2009 Aug; 83:46–8.
14. Rich P. et al. JAAD 2016; 74:134–142.

Recipes with an adaptogenic effect on the body

Adaptogenic - an action that increases the body's resistance to a harmful external environment.

1. Eleutherococcus senticosus extract. Take 20-30 drops 3 times a day, half an hour before meals. The course is a month.
2. Tincture of high aralia. Take 30-40 drops 3 times a day, half an hour before meals.
   The course is a month. Aralia high
3. Tincture of Schisandra chinensis fruits. Take 20-30 drops 2-3 times a day, before meals.
4. Tincture of high quality lure. Take 30-40 drops 2-3 times a day, before meals.
5. Rhodiola rosea root extract. Take 10-30 drops 2-3 times a day, half an hour before meals.
6. Greater celandine decoction. In a ratio of 1:20, take 1 tbsp. 3 times a day.
7. Tincture of sea buckthorn. Take 30 drops 3 times a day.
8. Tincture of common barley seeds (50%). Take 30 drops 3 times a day.
9. Infusion of chaga (birch mushroom). Pour the dried mushroom with cold boiled water for 4 hours, then grind it in a mortar. Fill with the same water in a ratio of 1:5, leave for 2 days. Drain the liquid and squeeze out the sediment. Take a glass a day, half an hour before meals.
10. The drug "Befungin". The drug also contains birch mushroom extract (chaga).
    Dilute 2 tsp. drug in 150 ml. boiled water, take 1 tbsp. l. 3 times a day, half an hour before meals. The course is 3-5 months, with a break of 7-10 days. Befungin

Traditional methods for normalizing the functioning of the adrenal glands

The adrenal glands are involved in metabolism and help the body adapt to unfavorable environmental factors. With psoriasis, their function is impaired and the necessary hormones are no longer produced.

1. Infusion of black elderberry flowers. Take 2 teaspoons of the plant and pour boiling water over it.
   Take 2 tbsp. l. 5-6 times a day. Black elderberry
2. Infusion of herb trifidum. Ratio 1:20, take 1 tbsp. l. 3 times a day.
3. Black currant infusion (5%). Take 300-500 ml per day.
4. Infusion of three-leaf watch. Take 2 tsp. leaves, pour a glass of boiling water. Take a quarter glass 2-3 times a day, half an hour before meals.

Vitamin teas for patients with psoriasis

For psoriasis, take vitamin teas, they replenish the lack of substances and help fight the disease.

Rose hips and flowers

1. Vitamin tea No. 1. Pour 2 cups of boiling water over rose hips and black currants (1 tsp each) and leave for an hour. Drink half a glass 3-4 times a day.
2. Vitamin tea No. 2. Pour 2 cups of boiling water over rose hips and rowan berries (1 tsp each) and leave for an hour. Drink half a glass 3-4 times a day.

Sources

• Spielvogel I., Spałek K., Badora K., Proćków J. Traditional knowledge and practice of the Triassic variegated clay from Silesia (Krasiejów), Poland, in human medicine. // J Ethnobiol Ethnomed - 2021 - Vol17 - N1 - p.10; PMID:33596953
• Rodriguez-Jato Q., Pereira AR., Batalla A., Abalde MT., Salgado-Boquete L., Martinez-Reglero C., Fernández-Redondo V., Florez A. Hospitalization in Patients with Psoriasis: Impact of Biological Therapies on Temporal Evolution. // J Drugs Dermatol - 2021 - Vol20 - N2 - p.208-214; PMID:33538560
• Magrey MN., Danve AS., Ermann J., Walsh JA. Recognizing Axial Spondyloarthritis: A Guide for Primary Care. // Mayo Clin Proc - 2020 - Vol95 - N11 - p.2499-2508; PMID:32736944
• Hsu SH., Tsai TF. Evolution of the inclusion/exclusion criteria and primary endpoints in pivotal trials of biologics and small oral molecules for the treatment of psoriasis. // Expert Rev Clin Pharmacol - 2022 - Vol13 - N3 - p.211-232; PMID:32167790
• Demirtas S., Houssais C., Tanniou J., Misery L., Brenaut E. Effectiveness of a music intervention on pruritus: an open randomized prospective study. // J Eur Acad Dermatol Venereol - 2020 - Vol34 - N6 - p.1280-1285; PMID:31838780
• Vandendorpe AS., de Vlam K., Lories R. Evolution of psoriatic arthritis study patient population characteristics in the era of biological treatments. // RMD Open - 2022 - Vol5 - N1 - p.e000779; PMID:30740243
• Savage L., Goodfield M., Horton L., Watad A., Hensor E., Emery P., Wakefield R., Wittmann M., McGonagle D. Regression of Peripheral Subclinical Enthesopathy in Therapy-Naive Patients Treated With Ustekinumab for Moderate -to-Severe Chronic Plaque Psoriasis: A Fifty-Two-Week, Prospective, Open-Label Feasibility Study. // Arthritis Rheumatol - 2022 - Vol71 - N4 - p.626-631; PMID:30468001
• Stinco G., Balato N., Buligan C., Campanati A., Dastoli S., Di Meo N., Gisondi P., Lacarubba F., Musumeci ML., Napolitano M., Offidani A., Pescitelli L., Piaserico S., Piccirillo A., Prignano F., Errichetti E. A multicenter retrospective case-control study on Suspension of TNF-inhibitors and Outcomes in Psoriatic patients (STOP study). // G Ital Dermatol Venereol - 2022 - Vol154 - N4 - p.392-399; PMID:30251810
• Ogawa E., Okuyama R., Seki T., Kobayashi A., Oiso N., Muto M., Nakagawa H., Kawada A. Epidemiological survey of patients with psoriasis in Matsumoto city, Nagano Prefecture, Japan. // J Dermatol - 2022 - Vol45 - N3 - p.314-317; PMID:29047148
• Vavricka SR., Gubler M., Gantenbein C., Spoerri M., Froehlich F., Seibold F., Protic M., Michetti P., Straumann A., Fournier N., Juillerat P., Biedermann L., Zeitz J ., Misselwitz B., Scharl M., Heinrich H., Manser CN., Safroneeva E., Raja Ali RA., Rogler G., Schoepfer AM., Greuter T. Anti-TNF Treatment for Extraintestinal Manifestations of Inflammatory Bowel Disease in the Swiss IBD Cohort Study. // Inflamm Bowel Dis - 2022 - Vol23 - N7 - p.1174-1181; PMID:28452862

Treatment: from X-ray to gene

The very first external remedies for the treatment of psoriasis appeared at the turn of the 18th–19th centuries. They were made on the basis of poisonous arsenic and were used almost until the middle of the twentieth century. Doctors also tried to use mercury, from the beginning of the twentieth century - X-rays and even pure radium, discovered by Pierre and Marie Curie (the latter method, fortunately, did not become widespread, since Marie herself died quite soon from aplastic anemia due to high doses of radiation). Other - not so radical - antipsoriatic drugs used at that time included drugs based on salicylic and pyrogallic acids, drugs containing tar, sulfur, naphthalan, grease, etc. [11] However, scientifically based methods of treating psoriasis appeared relatively recently.

Clinical researches

The conducted clinical study proves the high efficiency, safety and tolerability of products for daily skin care of children with mild and moderate forms of atopic dermatitis and during remission, accompanied by a decrease in the quality of life of patients. As a result of therapy, a decrease in the activity of the inflammatory process, a decrease in dryness, itching and flaking was noted.

The products are recommended by the St. Petersburg branch of the Union of Pediatricians of Russia.

It has been clinically proven that La-Cri cream for dry skin moisturizes and nourishes the skin, relieves itching and irritation, and also soothes and restores the skin.

Sources:

1. Chapman M. Shane, Habiff Thomas P., Zug Catherine A., Dinoulos James G. H., Campbell James L., Dermatology. Handbook of differential diagnosis, MEDpress-inform, 2014.
2. Sukolin Gennady Ivanovich, Illustrated clinical dermatology. Brief alphabetical reference book, Lux Print publishing house, 2010.
3. Sukolin Gennady Ivanovich, Clinical dermatology. A short guide to the diagnosis and treatment of dermatoses, Notabene, 2017.