Clotrimazole for men - instructions for use of cream, tablets and ointment

Compound

Gel 1% contains the active substance clotrimazole at a concentration of 10 mg/g and auxiliary components: propylene glycol, macrogol 400, carbomer, rectified ethyl alcohol 96% from food raw materials, glycerol, sage ethereal extract.
The 1% cream contains the active ingredient clotrimazole at a concentration of 10 mg/g and auxiliary components: cetostearyl and benzyl alcohols, polysorbate 60, synthetic spermaceti, octyldodecanol, sorbitan stearate, water.

The 1% ointment contains the active ingredient clotrimazole at a concentration of 10 mg/g and auxiliary components: polyethylene oxides 400 and 1500, propylene glycol, methylparaben, nipagin.

The 1% solution contains the active ingredient clotrimazole at a concentration of 10 mg/ml (in terms of dry matter) and auxiliary components: polyethylene glycol 400, propylene glycol, ethanol 96%.

1 suppository (candle) contains 100 mg of the active ingredient clotrimazole and semi-synthetic glycerides in the volume required to obtain a suppository weighing 2 g.

The tablets contain 100, 200 or 500 mg of the active ingredient clotrimazole and auxiliary components: lactose in the form of monohydrate, potato starch, adipic acid, sodium bicarbonate, silicon dioxide in colloidal form, sodium lauryl sulfate.

Clotrimazole - instructions for use for men

As a result of a decrease in general or local immunity, the fungus begins to multiply more actively, which leads to unpleasant symptoms in the form of itching, burning, and cheesy discharge. The causative agent of candidiasis can affect not only the skin, but also the mucous membranes. To prevent the pathology from becoming chronic, it is important to start treatment on time. For this, various antifungal drugs are used, for example Clotrimazole. The dosage of the drug is the same for women and men. The medicine itself is available in several forms, but with one active ingredient.

Composition and release form

There are several different forms of Clotrimazole. The active ingredient in them is the substance of the same name - clotrimazole. Auxiliary ingredients differ for the specific form of the drug. The composition is described in more detail in the table:

Pharmacodynamics and pharmacokinetics

The active substance of the drug is an imidazole derivative. It is effective against pathogenic fungi, including the following microorganisms:

• dermatophytes;
• dimorphic fungi;
• yeast-like fungi.

The mechanism of action is to block the synthesis of nucleic acids, proteins and ergosterol. These substances are necessary for the construction of microorganism membranes. Due to the suppression of their synthesis, fungal cells are damaged and it dies. A low concentration of the drug has a fungistatic effect. It consists in suppressing the growth of fungus. At a dose above 20 μg/ml, the drug exhibits a fungicidal effect, i.e. destroying microorganism.

When used topically, the active substance is absorbed by the epidermis. The highest level of concentration is observed in the reticuloderm. Clotrimazole also penetrates the keratin of nails. The drug practically does not penetrate into the systemic circulation. In the liver it is metabolized to inactive substances, which are then excreted in the urine. When used intravaginally, i.e. when introduced into the vagina, 5-10% of the active component is absorbed. The substance is also metabolized in the liver.

Indications for use

Clotrimazole for men against thrush is used to treat certain diseases. Common indications are skin damage by fungal microorganisms such as yeast, mold, and dermatophytes. The drug also helps in cases of lichen and erythrasma. Other indications for use:

• nail fungus (onychomycosis);
• trichophytosis;
• candidiasis;
• dermatomycosis;
• fungal erosion;
• athlete's foot;
• candidiasis;
• genital superinfections.

Release form

• gel 1% (pack of 20 and 40 g);
• cream 1% (tubes 15, 20, 30 and 50 g);
• ointment 1% (tubes 15, 20, 30 and 40 g);
• 1% solution (15 ml bottles);
• vaginal suppositories 0.1 g (package No. 6);
• vaginal tablets 0.1, 0.2 or 0.5 g (packaging No. 1, No. 3, No. 6; tablets are equipped with an applicator).

Clotrimazole can also be produced in the form of granules, powder for external use, or spray.

The drug is intended for local (including intravaginal) and external use; tablets for oral administration are not available.

Pharmacodynamics and pharmacokinetics

Clotrimazole is an imidazole .

In vitro, it exhibits high activity against the most pathogenic fungi that can cause serious infectious complications, namely:

• dermatophytes (Microsporum sp., Epidermophyton floccosum, Trichophyton sp.);
• yeast-like fungi (Cryptococcus neoformans, Candida sp.);
• dimorphic fungi (Histoplasma capsulatum, Paracoccidicides brasiliensis, Coccidiodes immitis).

The mechanism of action of clotrimazole is based on its ability to block the synthesis of proteins, nucleic acids and ergosterol, which is necessary for the construction of cell membranes of fungi. As a result, the cell membranes of the fungi are damaged and the cells die.

At low concentrations, clotrimazole has a fungistatic effect. If the dose exceeds 20 mcg/ml, the drug has a fungicidal effect, and not only on proliferating cells.

When used in high doses, it helps to increase the concentration of hydrogen peroxide in the fungal cell to a toxic value and, as a result, destroys the fungal cells.

When applied topically, the drug is absorbed by the epidermis. The highest concentration of the substance is determined in the reticuloderm. It is also able to penetrate the keratin of nails.

Clotrimazole enters the systemic circulation in very small quantities. Metabolized in the liver to inactive substances that are excreted from the body in feces and urine.

When administered intravaginally, 5 to 10% of clotrimazole is absorbed. The absorbed substance is metabolized in the liver. Metabolic products are excreted in bile.

Clotrimazole 20 g 1% ointment for external use

Instructions for use Clotrimazole 1% 20 g ointment for external use

Description of the dosage form

A homogeneous ointment of white or almost white color.

pharmachologic effect

Antifungal agent.

Pharmacokinetics

It is poorly absorbed through the skin and mucous membranes and has virtually no systemic effect. Accumulates in the stratum corneum of the epidermis, penetrates into the keratin of the nails. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes.

Pharmacodynamics

An antifungal agent from the group of imidazole derivatives for external use. Clotrimazole reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the microbial wall, and leads to a change in its structure and properties. In small concentrations it acts fungistatically, and in large concentrations (more than 20 μg/ml) it is fungicidal, and not only on proliferating cells. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells. Active against pathogenic dermatophytes (Trichophyton rubrum. Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis); yeast and mold fungi (Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Indications for use

Fungal diseases of the skin, including skin folds and feet, caused by dermatophytes, yeast (Candida spp.), mold and other fungi and pathogens sensitive to clotrimazole: dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia, candidiasis, interdigital fungal erosion, fungal paronychia.

Mycoses complicated by secondary pyoderma, as part of complex therapy.

Lichen versicolor, erythrasma.

Contraindications for use

Hypersensitivity to clotrimazole or excipients, pregnancy (first trimester), children under 2 years of age.

With caution: lactation period, pregnancy (II and III trimester).

Use during pregnancy and children

The use of the drug in the first trimester of pregnancy is contraindicated. Clinical and experimental studies have not found that the use of the drug during pregnancy (II and III trimester) or during breastfeeding has a negative effect on the health of the woman or fetus (child). The question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

Application of the drug directly to the lactating mammary gland is contraindicated.

Side effects

Local reactions: burning, swelling, irritation and peeling of the skin, paresthesia, blistering, erythematous rashes.

Allergic reactions: itching, urticaria.

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Drug interactions

Nystatin, natamycin and amphotericin B reduce the effectiveness of clotrimazole when used simultaneously.

When using the ointment, negative interactions with other agents are unknown and should not be expected, since the resorption capacity of clotrimazole is very low.

Dosage

Externally.

For adults, in the absence of other prescriptions, it is recommended to apply the ointment 2-3 times a day in a thin layer to previously cleansed and dry affected areas of the skin and rub in gently. A single dose for a palm-sized surface area is a column of ointment 5 mm long. Regular use of the ointment is important for successful treatment. The duration of therapy is individual and depends on the severity and location of the disease. To achieve complete recovery, you should not stop treatment with the ointment immediately after the disappearance of acute symptoms or subjective complaints. The duration of therapy should average about 4 weeks.

Lichen versicolor is usually cured within 1-3 weeks, and erythrasma within 2-4 weeks.

For fungal diseases of the skin of the feet, it is recommended to continue therapy for about 2 weeks after the symptoms of the disease have subsided.

In children over 2 years of age, the drug is used in the doses indicated above.

Overdose

Low systemic absorption of the active component of the drug when applied externally makes overdose almost impossible.

Precautionary measures

Contact with the mucous membrane of the eyes should be avoided.

In patients with liver failure, the functional state of the liver should be periodically monitored.

If signs of hypersensitivity or irritation appear, treatment is stopped. If there is no effect within 4 weeks, the diagnosis should be confirmed. In children, avoid application to large surfaces.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive vehicles, operate machinery or engage in other hazardous activities that require special attention and quick reactions.

Indications for use: what is Clotrimazole ointment, cream, gel, suppositories and tablets for?

What do Clotrimazole ointment, gel, cream and solution help with?

The drug is prescribed for the treatment of fungal skin infections that are caused by molds and yeasts, dermatophytes and other pathogens sensitive to clotrimazole.

They are also used as remedies for lichen caused by Malassezia furfur and erythrasma (caused by Corynebacterium minutissimum).

Clotrimazole ointment, cream, gel and solution help: against nail fungus ( onychomycosis , fungal paronychia ), trichophytosis , dermatophytosis , fungal erosion and diaper rash, candidiasis , microsporia , epidermophytosis , dermatomycosis , complicated by secondary pyoderma mycoses.

Indications for the use of ointment, gel, cream and solution include infectious diseases, pathogens that are resistant to nystatin and a number of other antifungal agents.

for the treatment of pityriasis rosea , since this disease most likely has a viral or infectious-allergic origin, and may also be the body’s response to a severe shock or nervous breakdown. Clotrimazole is effective against fungal infections.

The use of Clotrimazole ointment, gel and cream with Clotrimazole in gynecology is indicated:

• for the treatment and prevention of thrush ;
• for the prevention of repeated fungal infections of the female reproductive system, which develop during long-term treatment with antibiotics or against the background of immunodeficiency conditions.

Also, solution, gel, cream and ointment in gynecology are used to sanitize the genital tract before delivery.

Candles - what are they for?

The indication for the use of vaginal suppositories is vaginal candidiasis and genital superinfections caused by microorganisms sensitive to clotrimazole. The drug is prescribed to women and, after the onset of sexual activity, to teenage girls.

What are Clotrimazole tablets for?

Clotrimazole tablets are used to treat blastomycotic infections of the vulva and vagina. In particular, the drug is prescribed for vaginitis caused by fungi of the genus Candida (including diseases caused by strains resistant to nystatin), caused by other pathogens sensitive to clotrimazole, superinfections of the genital organs, for sanitization of the genital tract before delivery.

Directions for use and dosage

Since suppositories and tablets are intended for intravaginal administration, they are not prescribed to men. To treat representatives of the stronger sex, ointment, gel, cream and solution are used. The duration of therapy is determined by the specific disease. It consists of external use of a cream, ointment, gel or solution. In men, it is difficult to treat thrush, because it can be asymptomatic, affecting not only the genitals, but also other places, for example, the mouth.

Clotrimazole ointment for men

Before applying the ointment to areas affected by fungus, they must be washed with soapy water and dried thoroughly. You need to lubricate the skin with the preparation, covering a small healthy area nearby. Apply the ointment in a thin layer up to 3 times a day, lightly rubbing until completely absorbed. To treat an area of ​​skin approximately the size of the palm of your hand, a strip of the drug 5 mm long is required. For male thrush, in case of damage to the glans, you need to apply the ointment to the foreskin of the penis.

Treatment continues until symptoms disappear and for another 2 weeks after their relief for prevention. Course of therapy for certain diseases:

• 3-4 weeks – for dermatomycosis;
• 2-4 weeks – with erythrasma;
• 1-3 weeks – for lichen.

Gel

Instructions for using the gel are similar to the principle of applying the ointment. The drug is distributed over clean, dried skin, affecting small healthy areas nearby. The gel is rubbed in with light massaging movements up to 2-3 times every day. This form of the drug is distinguished by the fact that it is well distributed over the skin and is quickly absorbed. It is convenient to use on hard-to-reach areas of the body.

Clotrimazole cream for men

Candidiasis and other fungal infections can be treated with cream. They lubricate the affected areas 2 or 3 times a day, lightly rubbing. The skin must first be washed and dried. Clotrimazole cream for men is used in the same way as the ointment. This applies to the treatment of candidal balanitis and balanoposthitis. The course of treatment in this case is 1-2 weeks. Therapy for dermatomycosis lasts 3-4 weeks. To exclude relapses of the disease, it is necessary to continue treatment for another 2 weeks after the symptoms of candidiasis disappear.

Clotrimazole solution

Before the application procedure, the skin must be washed with soapy water. This is especially true for areas between the fingers. After washing, the skin is dried and only then the solution is applied. They treat the lesions 2-3 times every day. The amount of solution should be such that the entire surface of the damaged skin can be moistened. If your feet are affected by mycosis, then you need to use the solution after each wash. Other features of the use of this form of the drug:

1. This form is preferable in the case of onychomycosis, i.e. nail fungus.
2. If the oral cavity is affected, it is treated with a cotton swab or swab up to 4 times a day. After the procedure, you need to refrain from drinking drinks and food for about an hour.
3. Clotrimazole drops can be used to treat men's ears, into which cotton swabs soaked in the drug are inserted. They are placed for 5-10 minutes 3-4 times daily.

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Side effects

Allergic reactions.

When applied to the skin, the following side effects are possible:

• burning;
• edema;
• the appearance of blisters;
• erythema;
• skin irritation;
• tingling sensation
• peeling.

Local use for urogenital mycoses may be accompanied by burning, itching, swelling and hyperemia of the mucous membrane, intercurrent cystitis , the appearance of vaginal discharge, increased urination, pain during sexual intercourse.

When applied topically for mycoses of the oral cavity, redness of the mucous membrane, tingling and burning sensation at the site of application of the drug, and irritation may be observed.

Instructions for use of Clotrimazole (Method and dosage)

Clotrimazole ointment, instructions for use

Before applying Clotrimazole ointment (Acri or other manufacturers), the affected areas of the body are first washed with soapy water and dried thoroughly.

The drug is applied to the affected areas (covering small areas of healthy skin around the lesion) in a thin layer from 1 to 3 r./day. and rub lightly.

For 1 treatment of an area the size of a palm, a 5 mm strip of ointment is sufficient.

Regardless of what pathogen causes the disease, treatment after relief of subjective symptoms is recommended to continue for another 2 weeks.

For dermatomycosis, the course of treatment lasts from 3 to 4, for erythrasma - from 2 to 4, for lichen versicolor - from 1 to 3 weeks.

If there is no clinical improvement after 4 weeks of regular use of the drug, the patient is sent for a repeat microbiological study and the treatment regimen is revised.

The use of ointment for thrush in women helps block the spread of fungal cells and, when higher doses are prescribed, ensures their complete destruction. For therapeutic purposes, Clotrimazole for thrush is used 2 times a day, rubbing the ointment into the affected areas of the perineum.

Until the drug is absorbed, it is recommended not to wear underwear.

For men, the method of use for thrush and other fungal infections of the genital organs ( candidal balanoposthitis , urogenital candidiasis ) is the same as for women.

The ointment is applied to the foreskin and glans penis and gently rubbed into the skin and mucous membrane. Frequency of applications - 2 times/day.

The drug is poorly absorbed into the skin, and its active substance is characterized by the ability to gradually accumulate in the upper layer of the skin. Thanks to these properties, Clotrimazole ointment is highly effective for thrush in men and women.

Clotrimazole cream, instructions for use

The cream is intended for topical use. For thrush and other fungal diseases, apply it to the affected areas twice or thrice during the day and rub in lightly.

If mycoparasites affect the genitals, to treat thrush, the cream is prescribed simultaneously to both partners. For candidal balanitis or balanoposthitis, clotrimazole cream for men is used in the same way as ointment.

The duration of the course depends on the indications for use and ranges from 1-2 (for candidal balanitis/vulvitis ) to 3-4 weeks (for dermatomycosis ).

To prevent relapse of the disease, it is very important not to stop treatment for another 2 weeks after the subjective symptoms of infection disappear. If there is no improvement after 4 weeks of therapy, the patient should consult a doctor.

Vaginal cream Clotrimazole is administered into the vagina in portions of 5 grams 1 time per day. within 3 days.

Instructions for Clotrimazole solution

Before applying Clotrimazole, the skin should be washed with warm soapy water (especially the areas between the fingers) and dried well. The affected areas are treated 2-3 times a day. The amount of solution should be sufficient for uniform application to the entire affected surface.

If the skin of the feet is affected, liquid Clotrimazole solution must be applied after each wash.

The solution is the most preferred dosage form for onychomycosis . This is due to the fact that it has the best penetrating properties.

For fungal infections of the oral cavity, the affected areas of the mucous membrane are treated with a cotton swab or swab, onto which drops are first applied (10 to 20 drops are enough to treat each ear). Frequency of procedures - 3-4 rubles/day.

After applying Clotrimazole, you should refrain from eating and drinking for an hour.

Clotrimazole drops are also effective against onomycosis caused by yeast fungi. Drops are administered into the ear using turundas: a twisted cotton ball is moistened in the solution and 3-4 times a day. Place it in the ear canal for 5-10 minutes. Treatment lasts from 3 to 4 weeks.

Instructions for Clotrimazole gel

The method of using the gel is similar to the method of using the ointment. The product is applied to the epidermis affected by mycoparasites 2-3 times a day. and rub in with light movements.

The peculiarity of this dosage form is that the gel is well distributed on the skin and is also well absorbed into it. This allows the drug to be used for treating hard-to-reach areas of the body.

The gel is used intravaginally in the same way as clotrimazole cream: 1 r./day. 5 grams each. The course of treatment is 3 days.

Clotrimazole vaginal tablets, instructions for use

In the absence of other prescriptions, Clotrimazole Acri tablets and synonymous drugs for thrush and other fungal infections of the genital organs are used:

• for 3 days, 1 tablet 2 times a day;
• for 6 days, 1 tablet 1 time per day.

How to administer Clotrimazole vaginal tablets? Before administration, the tablet is removed from the package and moistened with chilled boiled water. The drug should be administered in the “lying on your back” position with your knees bent.

In order for the tablet to completely dissolve and clotrimazole to work, a moist environment is necessary (otherwise, undissolved particles may spill out). Therefore, the tablet is inserted into the vagina as deeply as possible. It is optimal to carry out the procedure before bedtime.

Treatment must be stopped before menstruation begins. Menstrual flow will wash away the drug and it will not have the desired effect. During treatment with vaginal tablets, you should not use tampons, spermicides, intravaginal douching or any other vaginal products.

To sanitize the genital tract before delivery, a woman is given a single dose of 200 mg of clotrimazole.

During pregnancy, the drug is contraindicated in the 1st trimester. At later stages, clotrimazole does not have an adverse effect on the development of the fetus, however, the use of the applicator may be associated with certain risks.

Instructions for Clotrimazole suppositories

Suppositories for thrush are used intravaginally. The drug should be injected deep into the vagina, one dose daily for 6 days. A repeat course is possible after consulting a doctor.

Clotrimazole suppositories for thrush and other urogenital mycoses are not used during menstrual bleeding. Treatment must be completed before it begins.

During pregnancy, the drug in this dosage form is used from the 2nd trimester and in situations where the expected benefit to the mother outweighs the possible risks to the fetus.

Reviews allow us to conclude that the drug quickly destroys fungal colonies and eliminates the unpleasant symptoms of mycoses. Its other advantages include low price and a large selection of dosage forms.

How to take Clotrimazole

Recommended dose:

Clotrimazole cream is injected as deep as possible into the vagina once a day (preferably before bedtime) for 3 days without a break. A sufficient course of treatment with the cream is 3 intravaginal applications, according to the procedure described below. Additionally, a cream may be needed to relieve the external itching and burning sometimes associated with a vaginal yeast infection. Clotrimazole is for vaginal use only and should never be taken orally. The treatment course should not be carried out during the menstrual cycle. Treatment should be completed before the onset of menstruation. Although it is possible that sexual relations may occur during treatment with Clotrimazole, it is preferable for couples to wait until the end of the treatment course to prevent infecting your partner.

Applicator filling:

Remove the cap from the Clotrimazole tube, press and pierce the aluminum foil with the tube cap. To refill the applicator, screw the open end of the applicator barrel onto the threaded neck of the tube. Carefully begin squeezing the cream out of the tube. After this, the upward movement of the piston draws the required amount of cream into the applicator cylinder. As the applicator fills, the piston moves outward. When the plunger reaches its stop and stops, the proper amount of Clotrimazole has already been filled into the applicator and the applicator can be unscrewed from the tip of the tube. Close the cap and reserve the tube for the next use.

Insertion of the cream: Clotrimazole cream is inserted into the vagina in the same way as a tampon, standing, crouching or lying on your back, in a position convenient for you. Insert the filled applicator into the vagina. The depth of insertion depends on how comfortable you feel during insertion. Hold the applicator cylinder steady and insert the cream into the vagina, gently pressing the applicator piston until it stops. Inject the cream as deep into the vagina as possible, which will ensure the maximum effect of the drug. Remove the applicator.

Use for each procedure .

External use of the cream:

A small amount of Clotrimazole cream may be applied to the external opening of the vagina to provide additional relief from external symptoms. Squeeze a small amount of cream onto your finger and gently spread over the irritated vaginal area. The cream should be used once or twice a day and only during the period when external symptoms are present, no more than 7 days.

If you use more Clotrimazole than recommended

If you have used more Clotrimazole than recommended, consult your doctor immediately, contact the emergency and emergency department at your nearest hospital, even if there are no symptoms.

Possible side effects

If you develop a rash or new irritation while using the drug, stop using the drug and contact your doctor.

This is not a complete list of side effects. If unexpected side effects occur while using Clotrimazole, consult your doctor or pharmacist.

Side Effect Reporting:

If you notice any side effects, tell your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects by going to the website www.arpimed.com and filling out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Medicines and Medical Technologies named after. Academician E. Gabrielyan by going to the website www.pharm.am to the “Report a side effect of a drug” section and fill out the form “Card of reporting a side effect of a drug.” Scientific center hotline phone number: +37410237665; +37498773368

How to store Clotrimazole

Store at room temperature, dry and out of reach of children.

Shelf life – 3 years.

Package contents and additional information

What Clotrimazole contains

Each gram of Clotrimazole 2% vaginal cream contains:

active substance: clotrimazole – 20 mg;

other components: ceteareth-12, ceteareth-20, liquid paraffin, cetostearyl alcohol, methylparaben, propylparaben, propylene glycol, dimethicone, purified water.

What Clotrimazole looks like and contents of the pack

Homogeneous cream of smooth white color, odorless.

Description of packaging

50 g of vaginal cream in an aluminum tube along with 3 vaginal applicators and a leaflet in a cardboard pack. The capacity of one applicator is 6 g Clotrimazole 2% vaginal cream.

Vacation conditions

Dispensed by prescription.

Overdose

When applied to the skin and intravaginally, there is no risk of acute intoxication, since clotrimazole enters the systemic circulation in very small quantities.

In case of accidental ingestion of Clotrimazole, nausea, anorexia , vomiting, gastralgia , and liver dysfunction . In rare cases, pollakiuria , hallucinations , drowsiness, and allergic skin reactions are observed.

In this case, the patient is prescribed enterosorbents and symptomatic treatment. Gastric lavage is performed in situations where a life-threatening dose was taken within the previous hour, as well as in the presence of visible symptoms of an overdose (nausea, dizziness, vomiting).

special instructions

Avoid ingestion and contact with eyes.

For mycoses, all affected areas of the body should be treated simultaneously.

The use of vaginal tablets, unless otherwise advised by a doctor, is contraindicated in the presence of any of the following symptoms:

• acyclic vaginal bleeding;
• bloody discharge or pathological bleeding from the vagina, uterine hemorrhages ;
• dysuria;
• lower abdominal pain;
• open sores, blisters, or ulcers of the vagina or vulva;
• any unpleasant symptoms that are associated with the use of Clotrimazole (irritation, redness, burning, swelling, etc.);
• chills or fever with a temperature above 38 ° C;
• nausea and/or vomiting;
• vaginal discharge with an unpleasant odor;
• diarrhea;
• pain in the shoulder or back.

To prevent reinfection, treatment is prescribed to both partners simultaneously. The optimal dosage form for men is cream.

For trichomoniasis, in addition to the drug, chemotherapeutic agents are prescribed for systemic treatment ( Metronidazole ).

Which is better, Clotrimazole ointment or cream?

The choice in favor of one or another dosage form is made depending on the indications. Clotrimazole ointment for women and men is prescribed for diseases that are accompanied by increased dryness and flaking of the skin.

As a rule, these are skin mycoses caused by dermatophytes ( trichopytosis , microsporia ), athlete's foot inguinal , erythrasma , pityriasis versicolor , isolated cases of smooth skin candidiasis , mixed bacterial and fungal infections.

For weeping inflammatory processes, it is more advisable to use a cream that has a drying effect.

Description of the drug

Clotrimazole ointment is a time-tested remedy against thrush. This infection of the genital organs often develops with endocrine pathologies, hypothermia, and long-term use of antibiotics. When the body's defenses are weakened, pathogens of mycoses begin to become active. Candida fungi belong to the opportunistic microflora and are always present in small quantities in the vagina. Against the background of decreased immunity, they begin to rapidly multiply and infect the mucous membranes. If you use Clotrimazole ointment at this stage, you can do without taking systemic antimycotics. The drug quickly eliminates the symptoms of thrush:

• burning and itching in the vagina;
• redness, swelling, itching;
• pain during and after urination;
• cheesy discharge from the genitals.

The drug helps to quickly get rid of the symptoms of chronic vaginal candidiasis. With this form of pathology, thick mucus is rarely discharged from the vagina. Women suffer from excessive dryness of the mucous membrane, hyperemia, and dry erosions.

Even after a single application of the antifungal agent, the intensity of clinical manifestations decreases.

To enhance the therapeutic effect of the ointment, the doctor may prescribe the simultaneous use of other drugs. The effect of Clotrimazole is enhanced by immunomodulators, immunostimulants, and balanced complexes of vitamins and microelements.

Pharmacotherapeutic group and action

Clotrimazole ointment is used for the effective treatment of genital candidiasis. Its antifungal effect is based on the pharmacological properties of the active ingredient - an imidazole derivative. To build cell membranes, pathogenic fungi produce the organic compound ergosterol. Clotrimazole blocks enzymes that stimulate its biosynthesis and prevents the spread of infection. Under the influence of the ointment, the permeability of the membranes changes, so the cell gradually dissolves. The drug exhibits antimycotic activity against the following pathogenic fungi:

• dermatophytes;
• yeast-like and mold fungi;
• causative agents of lichen versicolor.

When used in small doses, the drug has a fungistatic effect, preventing damage to healthy tissues.
And frequent use of Clotrimazole ointment in large quantities helps to completely destroy thrush pathogens. The active ingredient enters into biochemical reactions with enzymes, increasing the concentration of hydrogen peroxide. Such an environment is toxic for fungi and causes the destruction of their cells. After applying the product to the vaginal mucosa, about 5-10% of the active ingredient of the ointment is absorbed. It is metabolized by liver cells and evacuated from the human body along with bile.

Release form, composition and packaging

On pharmacy shelves there is Clotrimazole ointment from Russian and Indian Polish manufacturers. Products from domestic pharmaceutical factories are much cheaper, varying between 20-30 rubles. The price of an imported drug can exceed 80-100 rubles. The drug is available in the form of a 1% ointment with a jelly-like consistency without a characteristic odor. In addition to the active ingredient, it contains the following auxiliary chemical compounds:

• propylene glycol;
• polyethylene oxide;
• methylparaben;
• nipagin;
• cetostearyl alcohol;
• glycerol
• Castor oil;
• distilled water.

Auxiliary components enhance and prolong the clinical effect of Clotrimazole. They create a pH environment as close as possible to the acidity of human skin and mucous membranes. Propylene glycol ensures maximum absorption of the active ingredient and its even distribution in tissues. And castor oil moisturizes the mucous membranes, accelerating their regeneration. Cetostearyl alcohol is added to the composition, which makes Clotrimazole ointment help women eliminate unbearable itching.

The external product is packaged in aluminum tubes of 15.0 g, 20.0 g, 30.0 g, 40.0 g. Secondary packaging is a cardboard box with instructions for use inside.

Clotrimazole analogs

Level 4 ATC code matches:
Daktarin

Oronazole

Isoconazole

Kandibene

Miconazole

Candide B

Nizoral

Kanesten

Mifungar

Ecodax

Econazole

Travogen

Bifonazole

Sebozol

Mycozolon

Mycozoral

Travocort

Mycospor

Mycospor Set

Dermazol

Synonyms of dosage forms for external use:

• Amyclone
• Imidil
• Kandibene
• Kandizol
• Candide
• Kanesten
• Kanizon
• Funginal
• Funugitsip

Analogues in the form of vaginal tablets:

• Candide
• Imidil
• Kandizol
• Kandibene
• Funginal
• Candid-B6
• Kanizon
• fungicip

Which is better: Candide or Clotrimazole?

Candida is synonymous with Clotrimazole. The basis of both drugs is the same substance, so there are no fundamental differences between them.

Clotrimazole or Pimafucin - which is better?

The main component of Pimafucin is the antimycotic antibiotic nitamicin . Sensitivity to the drug is predominantly caused by molds and yeasts (including the genera Penicillium, Candida, Cephalosporium, Aspergillus and Fusarium).

Pseudoallescheria boydii and dermatophytes are less sensitive to Pimafucin. That is, in situations where the cause of the disease is fungi of the genus Epidermophyton, Trichophyton or Microsporum, the choice should be made in favor of the drug Clotrimazole.

The use of Clotrimazole is less often accompanied by hypersensitivity reactions. In addition, it is less likely than Pimafucin to provoke imbalances in the microflora of the genital organs.

Clotrimazole during pregnancy and lactation

Cream, gel, ointment, solution, suppositories and vag. tablets during pregnancy can be used from the 2nd trimester.

Strictly controlled studies regarding the safety of use during pregnancy; therefore, Clotrimazole is not prescribed in the 1st trimester.

Clinical studies regarding the effect of the drug on fertility in women have not been conducted; no adverse effects were detected in animal experiments.

Clotrimazole tablets and suppositories during pregnancy (in the 2nd and 3rd trimesters) do not have a negative effect on the fetus, but using the applicator can be dangerous.

When breastfeeding, the drug is used with caution, since it is unknown whether it passes into milk.

Gel, solution, cream and ointment Clotrimazole during pregnancy is applied to the skin affected by mycoparasites 2-3 times a day. If vaginal tablets are prescribed, they should be administered without an applicator. The duration of the course depends on the localization of pathological changes, the severity of the disease and the effectiveness of treatment.

Reviews indicate that in most cases the drug is well tolerated, and adverse reactions due to its use occur very rarely.

Reviews of Clotrimazole

Solution, ointment, cream, gel, suppositories and vaginal tablets Clotrimazole - reviews are eloquent confirmation of this - this is a time-tested, inexpensive and very effective remedy for nail and skin , as well as for urogenital mycoses .

In addition, the drug is effective against age spots .

Reviews of Clotrimazole suppositories on forums are mostly as follows:

• “... It’s the only thing I use to treat thrush. The product is cheap, but it helps a lot. No side effects."

Important features of Clotrimazole, which are taken into account when prescribing it, are the possibility of:

• the use of suppositories, tablets, ointments, solutions, gels and creams for thrush during pregnancy;
• prescribing creams and ointments for the preventive treatment of a woman’s sexual partner.

No less good reviews from men about Clotrimazole ointment and reviews about the cream. The only drawback of the drug, men sometimes note, is that it should be used for a long time.

Reviews

Oksana, Voronezh: After the appearance of cheesy discharge, I immediately made an appointment with a gynecologist. The doctor said that girls can use not only Clotrimazole ointment, but also tablets for thrush. I used this combination for a week, after which I took a smear for testing. The results showed that I am completely healthy.

Zoya, Abakan: I treated myself with herbs for chronic thrush. There was constant pain in the lower abdomen, pain and unbearable itching. The gynecologist prescribed Clotrimazole, Fluconazole and Gynocomfort ointment for intimate hygiene. On the first day of treatment, almost all discomfort disappeared.

Clotrimazole price

The price of Clotrimazole in vaginal tablets in Russia is from 50 rubles per package of 100 mg 6 pcs. In Ukraine, the price of vaginal tablets starts from 30 hryvnia.

The price of Clotrimazole ointment 20 g in Russia is from 100 rubles; in Ukraine you can buy ointment for a price of 30 hryvnia.

The average price of a solution for external use in Russia is from 300 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Clotrimazole-Akrikhin solution for external use.
  approx. 1% fl. 15mlMedana Pharma A.O. RUB 331 order
• Clotrimazole cream 1% 20gGlaxoSmithKline Pharmaceuticals SA

  RUB 262 order

• Clotrimazole cream 1% 20gHyperion SA

  115 rub. order

• Clotrimazole lotion for nails. and skin micospray fl. 15 mlCorvette Pharma LLC

  130 rub. order

• Clotrimazole cream d/nar.prim. 1% tube 20g No. 1Ozon LLC

  RUB 139 order

Pharmacy Dialogue

• Clotrimazole-Akrikhin (vial 1% 15ml) Akrikhin OJSC

  330 rub. order

• Clotrimazole (vial 1% 15ml)Medana

  RUB 327 order

• Clotrimazole-Akrikhin ointment (tube 1% 20g) Akrikhin OJSC

  RUB 137 order

• Clotrimazole ointment (tube 1% 15g) Muromsky PZ

  63 RUR order

• Clotrimazole ointment (tube 1% 20g) Sintez (Kurgan) OJSC

  126 rub. order

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Pharmacy24

• Clotrimazole 25 g ointment PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine
  15 UAH. order
• Clotrimazole 100 g No. 6 vaginal tablets Evertogen Life Sciences Limited, India/Optimus Generics Limited, India

  31 UAH order

• Clotrimazole Fitofarm 15 g ointment PRAT "Fitofarm", Ukraine

  9 UAH order

• Clotrimazole 1% 20 g ointment Encube Ethicals Private Limited, India

  34 UAH order

• Clotrimazole Teva 200 mg No. 3 vaginal tablets Merkle GmbH, Nimechchina

  60 UAH.order

PaniPharmacy

• CLOTRIMAZOLE ointment Clotrimazole ointment 1% tube 20g India, Encube Ethicals

  43 UAH order

• CLOTRIMAZOLE ointment Clotrimazole ointment 15g Ukraine, Fitofarm ChAO

  12 UAH order

• CLOTRIMAZOLE tablets Clotrimazole tablets. vag. 100 mg No. 6 India, Optimus Generics Ltd

  31 UAH order

• CLOTRIMAZOLE tablets Clotrimazole tablets. vag. 100 mg No. 6 Poland, GlaxoSmithKline Pharmaceuticals

  41 UAH order

• CLOTRIMAZOLE liquid Clotrimazole solution 1% 25ml Ukraine, Borshchagovsky Chemical Plant PJSC

  20 UAH order

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