The effect of povidone-iodine on the eradication of highly oncogenic HPV types in women with cervical lesions

The benefits of iodine in the treatment of pimples

Rashes on the face immediately catch the eye. The foundation only partially masks the inflammation. Dermatologists do not recommend getting carried away with concealers. They clog pores and prevent processes from occurring naturally. As a result, new pimples and acne appear.

To hide rashes, use a drying agent. Iodine is suitable for this task. The benefits of iodine include the following properties:

Bactericidal action. Getting on the skin, iodine removes harmful microorganisms that provoke the appearance of acne and the formation of inflammatory foci. Oily skin is prone to breakouts because it attracts impurities. Iodine eliminates greasy shine, preventing the appearance of new pimples.

The benefits of iodine in treating pimples are obvious. It is important to adhere to the rules of use. We should not forget that iodine dries out the skin. If your face is dry, then it is better to avoid this product. To avoid causing a negative reaction, perform an iodine tolerance test. To do this, apply the product to an open area of ​​the body. If there are no rashes or itching, then it is allowed to use iodine to remove pimples.

Why is burning a pimple with iodine a bad idea?

The opinion that you can burn a pimple with iodine comes from a misunderstanding of its properties. Most often in medicine, its 5% solution is used, which has drying, antiseptic, disinfectant, and wound-healing effects.116

Under no circumstances should the drug be applied to an open wound, so do not treat the skin after squeezing out a pimple*. This can lead to tissue necrosis. The iodized solution is used as a decongestant, which is misunderstood by acne patients and they stock it in their acne medicine cabinet. 116

Long-term external use of iodine can lead to the development of the following side effects115:

• irritation;
• rhinitis;
• lacrimation;
• excessive salivation;
• Quincke's edema;
• acne.

Remember that iodine is a drug, so it is important to use it correctly in accordance with the instructions.

Using iodine for acne

We are accustomed to treating iodine as a safe remedy that is used to lubricate broken knees. But, like any medicine, this product requires compliance with the rules of use. Especially if you are going to apply iodine to your face. The product is used to eliminate various rashes:

Removing millet and whiteheads. Only the skin where a small area is covered with rashes is treated. Each pimple is treated separately, once a day, preferably before bed. Carry out a hygiene procedure in the morning. Then wipe your face with salicylic alcohol. As a result, inflammation will be relieved, and acne will quickly move into the final stage of development. Fight against comedones. Formed on oily skin as a result of accumulation of impurities. To get rid of comedones, prepare a medicinal solution that includes salt and iodine. Use purified water as the liquid. With the resulting solution, moisten a cotton pad and wipe the skin in the area of ​​the rash. Cleansing the face from internal acne. Similar to closed comedones. To avoid drying out your skin, try the recipe described above. To enhance the effect, crush one analgin tablet and add to the solution. This method is used when the rashes are profuse. Diluted iodine does not burn the skin, and analgin discolors the healing liquid. Before using the recipe, make sure that you are not allergic to analgin.

If there are a couple of pimples on your face, then apply it pointwise, after moistening a cotton swab in iodine.

After applying the product to the skin, you will feel a slight burning sensation. This is a normal phenomenon, iodine comes into effect, heals open wounds and fights germs. If after 10 min. if the itching and burning continues, wash the product off your face. The methods of using iodine for pimples are simple, and therefore have earned popularity among teenagers. During this period, girls and boys undergo a restructuring of the body, a hormonal surge. Such changes end with rashes on the face. Iodine is one of the available and inexpensive remedies for eliminating pimples.

The effect of povidone-iodine on the eradication of highly oncogenic HPV types in women with cervical lesions

Relevance

Over the past decade, significant advances have been made in understanding the role of human papillomavirus (HPV) in the development of cervical cancer (CC) and other anogenital cancers. HPV is the main etiological agent of cervical dysplasia and carcinoma [1]. CC is the third most common gynecological cancer in developed countries. In Russia, the number of deaths from cervical cancer has increased by 3,500 women per year. Approximately half of patients with cervical cancer are women of reproductive age (under 50 years old) [2]. Recently, more than 200 women aged 20–39 years die annually for this reason. HPV is a common virus that is transmitted horizontally through heterosexual contact. Approximately 80% of all women are infected with HPV at some point in their lives, but in about 90% the human papillomavirus (PVI) infection resolves spontaneously within a few years. In the absence of independent elimination, cervical cancer may develop. Almost 100% of squamous intraepithelial lesions and CC, about 43% of vulvar tumors and 70% of vaginal tumors are associated with PVI, which annually causes 530 thousand new cases of CC and 21 thousand cases of vulvar and vaginal cancer worldwide [3]. In the absence of a screening strategy, there is an increase in the incidence of cervical cancer and vulvar cancer in young women [4]. HPV is a double-stranded DNA virus belonging to the genus Papilloma
in the family
Papovaviridae
[5]. It has been established that HPV is the most common sexually transmitted infection and is the main cause of cervical squamous intraepithelial lesions and invasive cervical cancer. There are more than 100 types that infect the epithelium of the reproductive tract. Transmission of HPV occurs primarily through skin-to-skin contact and probably through disruption of the epidermis, where the virus can infect basal squamous epithelial cells [6].

Types of HPV and their role in the development of cancer processes

To date, more than 100 HPV genotypes have been identified in the female reproductive tract. 13 HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) are recognized as highly oncogenic (13HR) cancer-causing types. However, other types of HPV may also be associated with cancer. According to N. Munoz, two additional types of HPV - 73 and 82 - should be considered carcinogenic. G. Halec et al. demonstrated from a systematic review that HPV types 26, 53, 66, 67, 68, 70, 73 and 82 may be oncogenic [7]. One of the most important issues is that polymerase chain reaction (PCR)-based diagnostics used in epidemiological studies have limitations. Firstly, the PCR method detects not only highly oncogenic, but also other types of HPV. Second, some PCR tests using consensus primers have shown inconsistent results in identifying HPV types because the detection sensitivity of some HPV types is lower than that of others. Low-risk HPV types such as 6, 11, 40, 42, 43, 44, and 54 are associated with genital warts and low-risk anogenital lesions [8]. High-risk HPV types 16 and 18 together account for about 70% of cervical cancer cases, while low-risk HPV types 6 and 11 are responsible for 90% of genital warts [9]. The immune system plays an important role in controlling the development of cancer. The HPV genome encodes two oncoproteins - E6 and E7, capable of inactivating p53 proteins, and retinoblastoma (pRB) - regulators of cell proliferative activity. They are necessary for the emergence and maintenance of the malignant cell phenotype [10]. The adaptive immune response protects against HPV-induced diseases [11]. The progression of HPV-induced disease is associated with the lack of strong HPV-specific CD4+ and CD8+ T cell responses. Chemotherapy or radiation therapy influences immune regulatory activity and, in combination with vaccination, potentiates effective local HPV-specific T-cell immunity in mouse tumor models. Successful treatment of HPV-induced lesions can be achieved with low-dose cyclophosphamide, which modifies local immunity. Given the importance of the local microenvironment in the persistence of HPV-induced lesions and tumors, treatments that can locally shift the balance of immunoeffectors, such as cyclooxygenase-2 inhibitors, through the production of prostaglandin E2 and transforming growth factor β may be effective [12]. Vulvar carcinoma has two distinct carcinogenic pathways, one of which is associated with HPV type 16. It is the fourth most common invasive gynecological cancer, affecting mainly older women and is more common in Western countries [13]. Prognostic factors for the course of the disease include the presence or absence of metastases in the lymph nodes, as well as tumor size and recurrence. Relapse (hematogenous metastases) is observed in 40% of patients. The prognostic role of HPV in vulvar cancer is debated, with some studies showing better survival in women with HPV-positive vulvar tumors, others not [14]. An important issue remains the organization of screening programs. Such programs are being implemented effectively in New Zealand. National recommendations for a cervical cancer screening program recommend that all women aged 20 to 69 years who have ever had sexual intercourse be given a cervical smear within 3 years. If this is a primary screening smear or more than 5 years have passed since the previous test, it is recommended that the second smear be repeated one year after the first, and then after 3 years. After the introduction of this screening program, the incidence of cervical cancer decreased significantly, currently amounting to 5.4 per 100 thousand women [15]. In addition, a large study on the distribution of HPV genotypes in cervical samples was carried out in New Zealand. The material was collected from women with highly oncogenic HPV types (in 2009–2011) or suffering from invasive cervical cancer (in 2004–2010). The most common HPV types causing cervical neoplasia (cervical intraepithelial neoplasia - CIN 2 and 3) were HPV types 16 (51%), 52 (19%), 31 (17%), 33 (13%) and 18 (12 %). However, there was a trend toward increased rates of infection with HPV types 16 and 18 compared to other HPV genotypes in women aged 20–29 years. The most common HPV genotypes associated with invasive CC were HPV 16 (51%), 18 (21%), 31 (4%), 45 (3%) and 52 (3%) [16]. In 2008, New Zealand introduced the National Women's Immunization Program with the quadrivalent HPV vaccine (genotypes 6, 11, 16, 18). More recently, in 2013–2016, a study showed a decrease in the proportion of cervical intraepithelial neoplasia (CIN 2) associated with HPV 16/18 in a cohort of young New Zealand women, which may be associated with the implementation of the national HPV vaccination program. This study was significant because it was the first documented change in HPV genotype in women with cervical lesions after initiation of a vaccination program [17]. HPV type 16 is the most common genotype identified worldwide in patients with invasive CC, followed by HPV type 18. Eight HPV genotypes (16, 18, 31, 33, 35, 45, 52 and 58) lead to higher rates of CC progression [18]. The clinical guidelines of the Japanese Society of Obstetrics and Gynecology and the Japanese Association of Obstetricians and Gynecologists provide an algorithm for the management of patients with CIN, which includes HPV genotyping to determine the risk of progression to CIN 3 [19]. However, the relationship between HPV genotype and cancer prognosis remains controversial. Some studies have shown that HPV 18-positive tumors are associated with poor prognosis [20]. Other authors have stated that Chinese and British patients with tumors associated with HPV 16 and/or 18 have better survival, while in Taiwan favorable results were obtained for HPV 58- and 31-positive tumors [21]. On the contrary, other scientists have not found any associations between the HPV genotype and the prognosis of cervical cancer in Russian and Korean populations [22]. A cervical cytology study performed at three institutions in Japan demonstrated that HPV 18-positive tumors were associated with poor survival in women. Longer follow-up (102 months) confirmed that HPV 16-positive tumors correlated with better survival compared with HPV 18-positive tumors. These conflicting results may be due in part to geographic differences in HPV type prevalence [23].

Factors that increase susceptibility to HPV

Microbes are considered the main trigger factor for the development of malignant neoplasms. The Human Microbiome Project (HMP) has determined that 20% of all fatal malignancies are microbiologically induced. The ectocervix is ​​colonized by microbes, whereas the endocervix and upper genital tract are considered virtually sterile in healthy women. Changes in the cervicovaginal microbiome and processes such as bacterial vaginosis, cervical inflammation and increased vaginal pH influence susceptibility to cervical HPV. Women in different ethnic groups have different vaginal microbiomes [24]. Most cervicovaginal infections and vaginal discomfort are caused by Gardnerella vaginalis
or
Atopobium vaginae
[25], as well as Candida albicans [26].
The cervical epithelium becomes vulnerable to infectious microbial agents such as HPV [27]. With the development of modern sequencing techniques, it is becoming clear that the microbiome influences susceptibility to cancer through the production of harmful metabolites and their impact on cellular function, since deregulated metabolism and inflammation are hallmarks of cancer [28]. The relationship of specific microbes (prokaryotic and eukaryotic) with HPV infections and cervical neoplasia remains one of the significant research issues. It is known that the microbiome of healthy women is dominated by Lactobacilli
.
This constant vaginal species produces lactic acid in the form of fermentation of products, which leads to a decrease in vaginal pH to 3.5–4.5, creating a chemical barrier to pathogens [29]. High levels of L. iners
are associated with the risk of developing HPV-associated cervical lesions.
An increase in body mass index correlates with an increase in the abundance of L. iners
, which makes obesity a significant factor in the development of CIN [30].
L. iners are more adaptable to pH changes and a variety of metabolic conditions than other lactobacilli. L. kitasatonis
and
L. crispatus
in the cervix in combination with highly oncogenic HPV types increase the risk of developing CIN 3. Floral diversity correlates with the severity of CIN.
The presence of Sneathia sanguinegens, Anaerococcus tetradius,
and
Peptostreptococcus anaerobius
in the vaginal microbiome of Caucasian, Asian, and Black women is often associated with the development of CIN.
P. micros
is an uncommon taxon commonly found in the oral cavity, found in the salivary microbiome and common in the presence of cervical lesions.
It has been suggested that P. micros can penetrate the cervicovaginal tract as a result of oral sex [31]. A direct connection of HPV with the dominance of three fungi of the genera Candida
,
Malassezia
and
Sporidiobolaceae was discovered.
Malassezia are lipophilic fungi that parasitize the upper layers of human skin and cause superficial fungal infections such as atopic dermatitis and psoriasis.
Malassezia
is often found on the foreskin and glans penis in men. Malassezia produce bioactive indolysines, including aryl hydrocarbon receptor (AhR) activators. AhR receptors mediate many skin functions, including promoting cell division, and it has been suggested that Malassezia may be involved in skin carcinogenesis. A recent study found that certain cervicovaginal tract microbiome structure correlates with both highly tumorigenic types of PVI and CIN severity in a population of women of reproductive age. Therefore, searching for features of the cervicogenital microbiome may be an important step in understanding the biology of cervical neoplasia and developing new therapeutic regimens targeting the microbiota [32].

Treatment of dysplastic changes in the cervix

Because CIN primarily affects women of reproductive age, there is a need for early identification and improved treatment strategies for the most clinically significant CIN. Persistent infection with highly oncogenic HPV types is a necessary condition for the progression of cervical pathology. Primary (vaccination) and secondary prevention (cervical screening) can have a decisive impact on cancer prevention [32]. The search for drugs aimed at treating dysplastic changes in the cervix is ​​an important area of ​​gynecology. Iodine is an antiseptic that has been used in medical practice for more than 150 years. Povidone-iodine
is one of the most powerful and effective iodine-containing antiseptics with a wide spectrum of action.
The main difference of this drug is that when it is taken, microbial resistance does not arise; it is less likely than antibiotic-containing drugs to cause an allergic reaction. The antiseptic effect of povidone-iodine is associated with a strong oxidative effect. Under the influence of povidone-iodine, pores form in the membranes of microbial cells, which leads to disruption of the integrity of the cell membrane, damage to the cell and loss of viability. The drug has several advantages over other antiseptics. Firstly, it more effectively stops the proliferation of microorganisms even in large dilutions. Secondly, povidone-iodine has the widest antiviral spectrum of action, including enteroviruses, polio and herpes viruses, as well as adenoviruses and influenza virus. Povidone-iodine is a stable drug, its effectiveness does not change under the influence of physicochemical conditions at the site of inflammation, caused by changes in pH, proteins, blood, and the action of enzymes. In gynecological practice, it is most often used to treat inflammatory processes and prevent the development of complications after invasive interventions [33]. The drug has been demonstrated to induce the death of HeLa epithelial cells in rats. Additional evidence supporting the potent antitumor effects of the iodine molecule and iodolactones was established through cell culture studies. They found a significant reduction in cell growth in breast cancer. A decrease in proliferation under the influence of iodine molecules was also noted in other human malignant cell lines (neuroblastoma, glioma, melanoma, lung, colon, and pancreatic carcinomas) [34]. Comparative analysis of the antiproliferative/cytotoxic ability of I2, potassium iodide (KI), a combination solution of KI+I2, povidone-iodine and I2+ [KI+glycerol] on human carcinoma cells showed that povidone-iodine may be a potential tool for directly interfering with tumor growth. cells [35]. A randomized study conducted in the USA found that all 88 patients aged 23–67 years (mean 34.8 years) with abnormal cytology and the presence of a highly oncogenic HPV type after 2 courses of cervical cryotherapy and local treatment with povidone-iodine after 6 months after therapy, HPV was not detected [36]. Studies have shown that the use of the drug Betadine
® after treatment with condyloma with a solution for external use with a local necrotizing effect increases the effectiveness of treatment, reduces the incidence of bacterial infection and recurrence of PVI of the vaginal and cervical mucosa. In connection with the above, the feasibility of complex treatment of cervical pathology, including povidone-iodine, is obvious [37].

Conclusion

Understanding the characteristics of the persistence of PVI in the epithelium of the cervix and the associated process of development of diseases in this area determines the tactics of treating cervical injuries associated with HPV. There are many methods for treating genital HPV, but the recurrence rate of this disease is high. Therefore, a very promising direction is the development of complex therapy to prevent recurrence of HPV-associated cervical diseases. The use of povidone-iodine (for example, the drug Betadine®) in the complex therapy of PVI increases the effectiveness of treatment, reduces the incidence of bacterial infection, as well as the frequency of recurrence of PVI of the vaginal and cervical mucosa. Information about the authors: 1 Dubrovina Svetlana Olegovna - Doctor of Medical Sciences, Professor, Chief Researcher of the Research Institute of Obstetrics and Pediatrics; 2Krasilnikova Liliya Viktorovna – candidate of medical sciences, obstetrician-gynecologist; 1 Ardintseva Oksana Aleksandrovna - graduate student; 3 Varicheva Marianna Vladimirovna - obstetrician-gynecologist; 4Tsirkunova Nina Sergeevna - obstetrician-gynecologist, head of the gynecological department; 1 Afrikyan Oleg Arturovich - 6th year student; 1 Afanasova Pelageya Nikolaevna - 6th year student; 5 Gadzhibekova Naina Balabekovna - obstetrician-gynecologist. 1 Federal State Budgetary Educational Institution of Higher Education Rost State Medical University of the Ministry of Health of Russia. 344022, Russia, Rostov-on-Don, lane. Nakhichevansky, 29. 2 DAVINCI GROUP LLC. 344091, Russia, Rostov-on-Don, st. Tolmacheva, 117. 3 Municipal Budgetary Healthcare Institution "City Hospital No. 20 of Rostov-on-Don." 344091, Russia, Rostov-on-Don, Kommunistichesky Ave., 39. 4 Municipal Budgetary Institution "City Hospital No. 6 of Rostov-on-Don." 344025, Russia, Rostov-on-Don, st. Saryan, 85/38. 5 MBUZ "GBSMP". 347930, Russia, Rostov region, Taganrog, Bolshoy prosp., 16. Contact information: Ardintseva Oksana Aleksandrovna, e-mail: [email protected] . Transparency of financial activities: none of the authors has a financial interest in the materials and methods presented. conflict of interest . The article was received on November 26, 2018. About the authors : 1 Svetlana O. Dubrovina - MD, PhD, Professor, Principal Researcher of the Scientific Research Institute of Obstetrics and Pediatrics; 2 Liliya V. Krasilnikova - MD, PhD, obstetrician-gynecologist; 1 Oxana A. Ardintseva - graduate student; 3 Marianna V. Varicheva - obstetrician-gynecologist; 4 Nina S. Tsirkunova - obstetrician-gynecologist, Head of the Department of Gynecology; 1 Oleg A. Afrikyan - 6th year student; 1 Pelageya N. Afanasova - 6th year student; 5 Naina B. Gadzhibekova - obstetrician-gynecologist. 1 Rostov State Medical University. 29, per. Nakhichevanskiy, Rostov-on-Don, 344022, Russian Federation. 2 LLC "DAVINCI GROUP". 117, Tolmacheva sr., Rostov-on-Don, 344091, Russian Federation. 3Rostov-on-Don City Hospital No. 20. 39, Kommunisticheskiy pass., Rostov-on-Don, 344091, Russian Federation. 4 Rostov-on-Don City Hospital No. 6. 85/38, Saryana str., Rostov-on-Don, 344025, Russian Federation. 5 City Emergency Hospital. 16, Bolshoy prosp., Taganrog, Rostov region, 347930, Russian Federation. Contact information: Oxana A. Ardintseva, e-mail: [email protected] . Financial Disclosure: no author has a financial or property interest in any material or method mentioned. Received 11/26/2018.

Iodine for pimples: side effects

Budget cost, ease of application, quick results - these are the positive aspects of iodine. But, there are negative points. The negative aspects are associated with the incorrect use of the product and its features. Side effects of iodine in the treatment of pimples:

Chemical burns. Iodine should not be applied in its pure form to the entire surface of the skin. Avoid getting the product on healthy areas. To treat the entire damaged area, make iodine-based solutions or apply targeted treatments. To do this, soak an ear stick in iodine. Then bring it to the pimple and hold it for 5 seconds, lightly pressing on the stick. Next, proceed to treating the remaining rashes. Yodism. This is a disease that means that a large amount of iodine has accumulated in the body. The disease causes serious consequences for human health. The excess is determined during testing. But the disease can also be detected at home. It is characterized by a rusty coloration of the oral cavity and an unpleasant odor. Patients complain of weakness, a feeling of dry mouth, upset stomach and vomiting. The body tries to independently remove excess iodine in any way. The product removed through the skin irritates the epidermis, causing acne and inflammatory areas.

If you notice that more pimples appear after using iodine, stop the treatment course.

If you have dry skin, then watch the reaction after applying iodine. Since the product dries out pimples, when it comes into contact with healthy skin, it leads to peeling. Itching, allergic reactions, a feeling of tightness on the face are signs indicating iodine intolerance.

Traditional methods of getting rid of papillomas

Medicine did not appear today, but our ancestors have always treated diseases. To get rid of papillomas, the following traditional methods of treatment have been offered for many years:

• juices of celandine and Kalanchoe;
• laundry and tar soap;
• castor and tea tree oils;
• soda and ammonia;
• garlic and green walnut peel;
• iodine and brilliant green.

All of them are good to one degree or another, they help get rid of an unsightly cosmetic defect or leave it unchanged. We are interested in self-medication of papillomas with iodine - is it possible, and whether it is necessary to do it.

Rice. 2. Cauterization of papillomas with iodine should be carried out pointwise, preventing the drug from spreading.

How to use iodine for acne?

To avoid damaging healthy skin, act locally. The process of applying iodine comes down to treating each pimple. For heavy rashes, an iodine-saline solution is prepared. The low concentration of the product protects delicate skin from burns. It is important not only to apply iodine correctly, but also to prepare the skin before and after the procedure.

How to use iodine for acne?

Cleanse your body or face of impurities. To do this, use an antibacterial lotion or toner for problem skin. You should not wash your face with soap before the procedure, as this will dry out the skin. Prepare some cotton swabs. Treat every pimple. Do not hold the stick for long, otherwise you will get burned. Carry out the procedure at night. Iodine turns the face red and it takes time to remove the product. Apply antibacterial cream. After treating your face, lubricate your skin with cream. Aftershave lotion will also do. After exposure to iodine, you should not apply moisturizer or oils to your face.

If the skin is delicate, then dilute the iodine with herbal decoctions. Anti-inflammatory medicinal plants are suitable. These are calendula flowers, chamomile or aloe juice. In addition to the herbal extract and iodine, add purified water.

Examples of the most common injuries

The skin here is very soft and sensitive, so it is most susceptible to bruises and abrasions. First of all, you need to wash the wound with plenty of clean running water. If necessary, apply ice or a cold object - this will help quickly stop the bleeding. Next, apply a clean cotton swab or gauze bandage to the wound. For several days you need to wash the wound with chamomile decoction, you can use furatsilin. If the wound is serious enough, then it is necessary to show the child to a surgeon.

Another common childhood injury is head trauma. Such injuries are divided into open and closed. If the wound is open, then, as a rule, the soft tissues of the head are damaged and the wound bleeds. In this case, you should immediately call an ambulance. If the injury is closed, it may be accompanied by swelling, swelling, and sometimes scratches and abrasions. In this case, the mother should apply a cold object to the child’s head - ice, a cold compress. It is worth paying attention if the child becomes sleepy after a bruise and shows signs of nausea and dizziness. Such symptoms accompany concussions of varying severity. In this case, you should immediately contact a specialized institution.

A common childhood injury is nasal injury. Children's cartilage is still quite soft, so it does not break. And yet it is quite possible to get a slight displacement or abrasion. Having assessed the severity of the injury, the mother should decide whether to show the child to an otolaryngologist in order to avoid future problems with the nasal septum.

Children often cut their eyebrows. In this case, such an injury is accompanied by severe bleeding. In this case, you should also stop the bleeding by applying a cold compress or ice. Next, treat the wound with brilliant green and apply a bactericidal patch.

Children can often lose a tooth in children's games. If a child has lost a baby tooth, rinse the mouth with plenty of water. If a molar tooth has fallen out, you need to find it, wash the tooth with cold water and contact the dentist for tooth reimplantation.

The cheeks can also be frequently injured in children. With such an injury, the degree of injury should be assessed; if the soft tissues inside the cheeks are damaged, they should be treated with chamomile decoctions or disinfectant solutions. Parents cannot always protect their baby from injury. But knowing the first rules of necessary assistance in case of injury, you can significantly alleviate the baby’s suffering, and for any minor bruises or wounds, you can always use Lekker products.

When we were children, our parents usually treated any bruise or abrasion with iodine or brilliant green.

These are two completely different in properties and composition of the means, the result of the use of which has always had the maximum impact on the injury. Times are changing and now you can use both iodine and brilliant green in a convenient and economical form from the Lekker company.

Is it possible to smear pimples with iodine?

Summarize. Iodine actually has properties that dry out and clear up existing breakouts. In this case, the product acts locally, removing only those pimples to which iodine is applied. Do not smear the entire skin, otherwise burns will form. Plus, active use will lead to oversaturation of the body with iodine.

Since the use of the product has both positive and negative sides, the question arises: is it possible to smear pimples with iodine? It is possible if the rules of application and course of treatment are followed. 7 days are enough to dry out pimples and remove inflammation. It is not recommended to resort to this method if the body or face is heavily covered with rashes. Iodine is used to clear up a couple of pimples. At the same time, external problems do not go away. If the body is contaminated with toxins, the rash will continue. Therefore, many doctors have a negative attitude towards cauterizing pimples with iodine. To remove toxins from the body and get rid of acne, take a course of Polysorb.

Iodine as a way to get rid of papillomas

More than half of the world's population is infected with papillomavirus.
Often the disease occurs in a latent form, that is, it does not manifest itself in any way. With a decrease in the body's protective functions, the human papillomavirus (HPV) begins to actively increase and spread, revealing itself in the following external manifestations: warts, papillomas, condylomas. Despite the fact that treatment of the virus should be carried out comprehensively, owners of papillomas begin to get rid of them at home, using all kinds of available means. Rice. 1. When immunity decreases, the human papillomavirus causes the formation of papillomas.

Iodine and papillomas

Strictly speaking, iodine is a chemical element, a halogen, under normal conditions it is in a solid crystalline state. The usual bottle from the pharmacy is the substance iodine dissolved in ethanol. Its spectrum of action is wide, it simultaneously has antiseptic, anti-inflammatory, antimicrobial, hypolipidemic, and local irritant properties. Its undeniable advantages include:

• inexpensive cost;
• constant availability in pharmacies;
• moderately gentle effect on the skin;
• good tolerance by the body;
• a small number of contraindications.

Rice. 3. Consult your doctor if self-treatment of papillomas has not been effective.

Stages of iodine treatment

The effect of treatment for genital warts will depend on factors:

1. Number of neoplasms.
2. Size of growths.
3. Locations.
4. Intensity of drug application.
5. Cauterization frequencies.

Treatment of condylomas with iodine is allowed for small single formations. Multiple large growths are best removed using traditional medicine.

The method of treating genital warts can be compared with chemical coagulation, only this remedy is characterized by greater safety in comparison with the acids that are part of chemical reagents. In order to remove condylomas with iodine, you need to be patient and be careful when applying the drug, as well as:

• Before the procedure, you need to make sure that the treatment area is clean and dry;
• It is advisable, in order to avoid burns, to treat the skin around the pathological area with cream, without touching the growth itself;
• smear the formations with a cauterizing solution 3-5 times a day, without missing a single day, until the growths fall off.

The result will take 7-10 days, provided that all stages of treatment are followed.