Gel Klenzit and Klenzit-S: reviews

Pimples and acne are a problem in modern society associated with poor environment, bad habits, exposure to ultraviolet radiation and poor diet.

Many cosmetic products only mask defects or are short-lived and stop after you stop using the product.

The drug Klenzit comes to the rescue . In this article we will look at the effect of the drug and find out which is better Klenzit or Klenzit S.

Important! Before using the drug, be sure to read the instructions and check whether you have any contraindications.

Comparison of the effectiveness of Klindovit and Klenzit

The effectiveness of Clindovit is quite similar to Klenzit - this means that the ability of the medicinal substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Klindovit is more pronounced, then using Klenzit even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Klindovit and Klenzit. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

The drug Klenzit-S - instructions for use

Gel Klenzit-S is a medicine for the treatment of papulopustular acne (pimples), which contains the topical retinoid adapalene and the antibiotic clindamycin.
Clindamycin is a bacteriostatic antibiotic of the lincosamide group with pronounced antimicrobial activity against the bacteria P.acnes and S.epidermidis. It is these bacteria that play an important role in the formation of inflammatory elements of acne (papules and pustules). Thus, the pharmacological effect of the drug will be provided by two active components - adapalene 0.1% and the antibiotic clindamycin 1%. Thanks to the presence of adapalene, this drug has all the effects of the Clenzit gel (we will not list them a second time, see them above) + there is antimicrobial activity due to the presence of an antibiotic in the composition.

→ Klenzit-S – official instructions (PDF)

Indications for use of Klenzit-S gel –

In the official instructions for this drug, we see that its only indication for this drug is also “acne.” We already wrote above that acne is represented only by non-inflammatory elements - white or blackheads (also called comedones). An antibiotic in the drug is needed only in the presence of inflammatory elements - such as papules, pustules or nodes. Therefore, we will use this drug only for acne.

Gel composition (in terms of 1 g):

Comparison of the safety of Clindovit and Klenzit

The safety of a drug includes many factors.

At the same time, in Klindovit it is quite similar to Klenzit. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Klindovit, as well as in Klenzit, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Clindovit does not have any risks when used, just like Klenzit.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Klindovit and Klenzit.

Gel Klenzit: instructions for use

Indications for use - according to the instructions, Klenzit gel has only one indication - “acne”, but this requires clarification. In fact, the instructions are not written entirely correctly and do not correspond to the modern international classification. The term acne implies that the patient has only non-inflammatory elements of acne - such as whiteheads or blackheads (they are also called closed and open comedones).

As for acne, there are 2 types - in the form of pustules (with pus inside) and in the form of papules without pus. In this case, papules can disappear without a trace over time, or transform into pustules. In general, the term “acne” is a colloquial expression, and their correct name is “papulopustular form of acne.” So, we can use the drug Klenzit both for the treatment of acne and for the treatment of pimples. But in the latter case, we will combine it with other drugs.

Composition of the gel "Klenzit" (in terms of 1 g):

* A homogeneous white gel, packaged in tubes of 15 or 30 g.

→ Klenzit gel official instructions (PDF)

Pharmacological action of the drug Klenzit -

The pharmacological effect is due to the presence of “adapalene 0.1%”, which belongs to the 3rd generation topical retinoids. The retinoid adapalene in the composition of the drug has the following effects:

• Suppression of hypersecretion of the sebaceous glands - increased activity of the sebaceous glands is one of the main mechanisms for the formation of acne and pimples. Adapalene inhibits the activity of sebocytes - the cells of the sebaceous glands, which are responsible for the production of fatty secretions (sebum). From personal experience I can say that from the first days of use the skin becomes much less oily.

• Reduction of follicular hyperkeratosis – hyperkeratosis of the follicular epithelium is the second most important mechanism that leads to the formation of acne and pimples. This process consists of thickening the layers of keratinocytes and disrupting their desquamation into the lumen of the follicle. Adapalene enhances the differentiation of keratinocytes in the follicles and facilitates their desquamation, which leads to a reduction in hyperkeratosis. In addition, adapalene facilitates the exfoliation of dead cells of the stratum corneum of the epidermis.

• Comedolytic effect - adapalene has the property of dissolving the fatty substrate that makes up acne (comedones). This leads to the release of clogged hair follicles and the unhindered removal of sebum to the surface of the skin. It should be noted that the comedolytic effect of adapalene is much more pronounced than that of azelaic acid.

• Anti-inflammatory effect – adapalene inhibits “chemotaxis” and migration of neutrophils to hair follicles, which prevents the formation of papules and pustules (pimples). Chemotaxis and migration of neutrophils to the follicles are associated with the fact that the enzymes of the P. acnes bacteria break down triglycerides from the secretion of the sebaceous glands into free fatty acids (monoglycerides). The latter are not only terribly comedogenic, but also stimulate chemotaxis and migration of neutrophils to the follicles.

Comparison of addiction between Klindovit and Klenzit

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Klindovit is quite similar to the similar values ​​in Klenzit. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Klindovit’s “syndrome” values ​​are quite small, however, the same as Klenzit’s.

Side effect

When applying the drug, patients may experience side effects , among which are the following reactions:

• skin hyperemia,
• skin irritation (in this case, you need to reduce the number of times of application or stop treatment for a while until the irritation disappears,
• strong burning sensation
• peeling of the skin at the site of application.

If unwanted side reactions occur, it is usually recommended to completely stop taking the drug until the inflammation disappears.

In this case, it is best to contact your doctor to find out his opinion and act on his instructions.

Comparison of side effects of Clindovit and Klenzit

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Klindovit's side effects are almost the same as Klenzit's. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Clindovit are similar to Klenzit: how quickly the body recovers after taking it and whether it recovers at all.

EXPERIENCE OF USING KLENSIT "S" GEL AND KLENSITE IN THE THERAPY OF ACNE Shishkina N.P., Protsenko V.N. Federal State Health Institution Medical Unit No. 97 FMBA of Russia, Voronezh INTRODUCTION.
Acne is one of the most common skin diseases. The incidence of acne in medical unit No. 97 by age group is as follows: 17 – 24 years –78%; 25 – 34 years old – 9%; 35 – 44 years old – 4%. Severe forms of acne occur in 18% of patients, and scars form in 22%. The development and course of dermatoses largely depends on family (genetic) predisposition. When collecting a family history, it was revealed that the more often acne occurs in relatives and the more severe it is, the more severe the course is observed in the offspring. Hereditary predisposition was identified in 68% of acne cases. The development of acne lesions in the face and neck reduces the quality of life of acne patients. All patients experience a feeling of anxiety, restlessness and irritability, which reduces the patients’ activity in social life. Patients with acne have reduced resistance to life's difficulties. Patients with acne note self-doubt, indecision, difficulty in establishing interpersonal relationships, which leads to limited communication with others and isolation. Often severe forms of acne are associated with endocrine pathology. Thus, late hyperandrogenic acne in women is more common with polycystic ovary syndrome, congenital dysfunction of the adrenal root. OBJECTIVE OF THE STUDY: to study the effectiveness of the drug Klenzit to improve the quality of life and emotional sphere of patients with this pathology. MATERIAL AND METHODS. In a study of microbial flora in 30 people with various forms of acne, the following predominated: Propionobacterium acnes - 22 patients (73.3%), Staphylococcus epidermidis - 17 (56.7%), Staphylococcus aureus - 9 (30%), viridans streptococcus - 2 (6.7%), pentostreptococcus - 2 (6.7%), yeast-like fungi - 6 (20%). As a result of these studies, it was found that in papulopustular and indurative forms of acne, the species composition of the microflora was limited to 2 - 4 microbial agents, in abscess and conglobate forms it reached 7. Propionobacterium acnes is most often found in acne, which confirms its important role in the development of the disease. The most common clinical form of acne is the papulopustular form (76% of patients). The basic drugs for this form of the disease are antibiotics for systemic and external use. The most important principles of rational antibiotic therapy are to prescribe a drug to which the pathogen is sensitive. A significant disadvantage of antibiotic therapy is the formation of resistance to them and the development of allergies. In this regard, in the medical unit, 30 patients were treated for acne with topical retinoids - the preparations klensit and klensit "C". Clensite (adapalene) acts on three parts of the pathogenesis of acne: regulates sebum secretion, has a pronounced anti-inflammatory and comedonoletic effect. Klenzit “C” contains, in addition to adapalene, clindomycin, which has a broad antibacterial effect. Complex therapy included: physiotherapy - D'Arsonval, cryomassage; external treatment - preparations Klenzit “S”, Klenzit. Special instructions are as follows. Avoid: 1. Staying in the sun. 2. Use of artificial ultraviolet radiation (solarium). 3. Do not use abrasive cosmetics (scrubs). 4. Do not use the gel to treat damaged skin and burns. 5. Do not use drying agents (those containing alcohol). 6. Avoid contact with eyes and mucous membranes. In the treatment of acne, initially, in case of a severe inflammatory reaction, Klenzit “S” was prescribed for 1 – 2 weeks. The drug was applied to clean skin once a day without rubbing. After a decrease in the pronounced inflammatory reaction, the drug Klenzit was prescribed. The study involved 30 people: 22 women and 8 men diagnosed with acne of moderate severity, papulopustular form. RESULTS. Complete clinical recovery - 21 patients (70%), significant improvement - 8 (26.6%), no effect - 1 (3.3%). Reduction of inflammatory elements in 64% of patients was observed after 20 days. Complete clinical recovery occurred after 6 weeks. In 33% of patients (10 people), after 7–9 days from the start of treatment, reactions characteristic of retinoids were observed: the appearance of erythema - 5 (50%), dryness - 3 (30%), burning - 1 (10%), moderate peeling — 1 (10%). These symptoms were self-limited; 3 patients were prescribed a moisturizer. CONCLUSION. 1. The preparations Klenzit “S” and Klenzit are an effective remedy in the treatment of acne. 2. The drugs Klenzit “S” and Klenzit should be used for acne as monotherapy and in combination with systemic therapy. 3. When treated with these drugs, minor adverse reactions are observed. ‹ Experience in the use of 1% Pimecrolimus cream in the treatment of organic forms of VitiligoUp Experience in the treatment of chronic recurrent vulvovaginal candidiasis ›

Baziron for acne

Which is better Baziron or Klenzit S ? This is a fairly common question, to which it is very difficult to give a quick definitive answer.

Baziron AS is practically the most effective means for intensive treatment using the external method. The most important advantage of this product is that Baziron provides the best doctor results in the shortest possible time.

This is the most important plus, because of which the product became popular. About other beneficial properties, use, application, as well as contraindications for use.

Baziron is a spot drug that, as a result of its work, gives patients numerous hopes.

Throughout its existence, the product has gained enormous popularity among many people suffering from acne. The drug has already collected thousands of positive reviews, including mine.

Along with Skinoren and Zenerit, this is the most effective remedy for external acne treatment:

1. The main advantage of the drug is Benzoyl peroxide, which is included in its composition. The use of this product simply cannot be expressed in words; after applying it, you will jump. Thanks to this action, a crust appears on the pimples and they go away.
2. The remedy also has the ability to fight through its special dindi (temporary relationship.
3. In addition, peroxide has excellent anti-inflammatory effects , significantly suppressing the proliferation of the bacterium Propionibacterium acnes, which is the main causative agent of acne.
4. Additional drugs do not help, but tend to have beneficial properties, of which we can highlight a reduction in skin oiliness .

Using Skinoren

Skinoren is an excellent analogue for the well-known drug Klenzit, so many patients often have the question of what is better to choose Skinoren or Klenzit?

To make the right choice, you need to carefully study all the nuances of the drug , as well as evaluate its properties and possible side effects.

The main component in Skinoren is a fairly effective azelaic acid . It is able to be quickly and intensively absorbed, providing its anti-acne properties.

Its use completely suppresses the possible spread of Propionibacterium acnes (this bacterium is only the causative agent of acne), and significantly reduces the oiliness of the skin surface.

Differin in the fight against acne

Differin is a unique and fairly consumable drug , which is usually used for external application, usually directs its action to completely prevent the appearance of comedones, helping to quickly get rid of acne.

Due to its high effectiveness, many doctors have a question about what is better to prescribe to the patient: Differin or Clenzit.

The high uniqueness of the presented product is the very first and main reason for choosing Differin as your personal choice. The product is simply ideal for the effective treatment of acne in various forms.

When acne becomes quite severe, then the effect-improving drug Differin should be combined with antibacterial drugs.

Due to its fairly high activity , Differin is a rather complex drug that requires extremely rare application .

It is usually carried out once a day, and is best used in the evening. Before going to bed, you need to thoroughly cleanse your skin and wait until it is completely dry.

When using the drug from one common tube, a very small amount of the contents of the gel or cream is usually squeezed out . Typically, such thickness and dimensions are only the size of a pea, so the cream is able to be rubbed into the skin with gradual, completely uniform movements.

When using the product simultaneously with other drugs , it is necessary to carefully understand the effect of each of them. Appointments must be made several hours apart.

special instructions

In the event of a completely accidental contact of the drug on the mucous membranes of the mouth, eyes or nose, you should immediately rinse the contact areas thoroughly with plain warm water.

This product should be used with caution for eczema or dermatitis . It is also not recommended to apply it simultaneously with cosmetics that have a drying and irritating effect on the skin.

It is important to avoid exposure to sunlight , as skin irritation may occur. Treatment can be continued in cases where solar exposure is practically reduced to zero, thanks to the use of special sun hats and glasses.

Adapalene, which is usually used in the evening, can be combined without problems with acne medications used in the morning.